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Amelioration of behavioral deficits in a rat model of Huntington's disease by an excitotoxic lesion to the globus pallidus.
Exp Neurol. 2004 Mar; 186(1):46-58.EN

Abstract

Four groups of rats, sustaining a striatal quinolinic acid (QA) lesion, a pallidal QA lesion, a combined striatal + pallidal lesion, or sham operation, were tested in spontaneous and amphetamine-induced activity, spatial navigation in a water maze, position discrimination and reversal in a wet T maze, and food manipulation. The striatal lesion markedly impaired rats' performance on the motor and cognitive tasks. In contrast, rats sustaining a bilateral lesion to the GP in addition to the striatal lesion performed similarly to sham-operated rats on the motor and cognitive tasks, although they showed a transient decrease in activity levels. Given that a similar dysfunction of basal ganglia circuitry is thought to subserve the behavioral alterations seen in QA-lesioned rats and Huntington's disease (HD) patients, the present results raise the possibility that manipulations of the external segment of the globus pallidus (the primate analogue of the rat GP) could ameliorate some of HD symptoms.

Authors+Show Affiliations

Department of Psychology, Tel-Aviv University, Ramat-Aviv, Tel Aviv 69978, Israel.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

14980809

Citation

Ayalon, Liat, et al. "Amelioration of Behavioral Deficits in a Rat Model of Huntington's Disease By an Excitotoxic Lesion to the Globus Pallidus." Experimental Neurology, vol. 186, no. 1, 2004, pp. 46-58.
Ayalon L, Doron R, Weiner I, et al. Amelioration of behavioral deficits in a rat model of Huntington's disease by an excitotoxic lesion to the globus pallidus. Exp Neurol. 2004;186(1):46-58.
Ayalon, L., Doron, R., Weiner, I., & Joel, D. (2004). Amelioration of behavioral deficits in a rat model of Huntington's disease by an excitotoxic lesion to the globus pallidus. Experimental Neurology, 186(1), 46-58.
Ayalon L, et al. Amelioration of Behavioral Deficits in a Rat Model of Huntington's Disease By an Excitotoxic Lesion to the Globus Pallidus. Exp Neurol. 2004;186(1):46-58. PubMed PMID: 14980809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amelioration of behavioral deficits in a rat model of Huntington's disease by an excitotoxic lesion to the globus pallidus. AU - Ayalon,Liat, AU - Doron,Ravid, AU - Weiner,Ina, AU - Joel,Daphna, PY - 2003/03/06/received PY - 2003/06/03/revised PY - 2003/06/16/accepted PY - 2004/2/26/pubmed PY - 2004/4/6/medline PY - 2004/2/26/entrez SP - 46 EP - 58 JF - Experimental neurology JO - Exp Neurol VL - 186 IS - 1 N2 - Four groups of rats, sustaining a striatal quinolinic acid (QA) lesion, a pallidal QA lesion, a combined striatal + pallidal lesion, or sham operation, were tested in spontaneous and amphetamine-induced activity, spatial navigation in a water maze, position discrimination and reversal in a wet T maze, and food manipulation. The striatal lesion markedly impaired rats' performance on the motor and cognitive tasks. In contrast, rats sustaining a bilateral lesion to the GP in addition to the striatal lesion performed similarly to sham-operated rats on the motor and cognitive tasks, although they showed a transient decrease in activity levels. Given that a similar dysfunction of basal ganglia circuitry is thought to subserve the behavioral alterations seen in QA-lesioned rats and Huntington's disease (HD) patients, the present results raise the possibility that manipulations of the external segment of the globus pallidus (the primate analogue of the rat GP) could ameliorate some of HD symptoms. SN - 0014-4886 UR - https://www.unboundmedicine.com/medline/citation/14980809/Amelioration_of_behavioral_deficits_in_a_rat_model_of_Huntington's_disease_by_an_excitotoxic_lesion_to_the_globus_pallidus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014488603003121 DB - PRIME DP - Unbound Medicine ER -