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Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies.
Arch Intern Med 2004; 164(4):370-6AI

Abstract

BACKGROUND

Few epidemiologic studies of dietary fiber intake and risk of coronary heart disease have compared fiber types (cereal, fruit, and vegetable) or included sex-specific results. The purpose of this study was to conduct a pooled analysis of dietary fiber and its subtypes and risk of coronary heart disease.

METHODS

We analyzed the original data from 10 prospective cohort studies from the United States and Europe to estimate the association between dietary fiber intake and the risk of coronary heart disease.

RESULTS

Over 6 to 10 years of follow-up, 5249 incident total coronary cases and 2011 coronary deaths occurred among 91058 men and 245186 women. After adjustment for demographics, body mass index, and lifestyle factors, each 10-g/d increment of energy-adjusted and measurement error-corrected total dietary fiber was associated with a 14% (relative risk [RR], 0.86; 95% confidence interval [CI], 0.78-0.96) decrease in risk of all coronary events and a 27% (RR, 0.73; 95% CI, 0.61-0.87) decrease in risk of coronary death. For cereal, fruit, and vegetable fiber intake (not error corrected), RRs corresponding to 10-g/d increments were 0.90 (95% CI, 0.77-1.07), 0.84 (95% CI, 0.70-0.99), and 1.00 (95% CI, 0.88-1.13), respectively, for all coronary events and 0.75 (95% CI, 0.63-0.91), 0.70 (95% CI, 0.55-0.89), and 1.00 (95% CI, 0.82-1.23), respectively, for deaths. Results were similar for men and women.

CONCLUSION

Consumption of dietary fiber from cereals and fruits is inversely associated with risk of coronary heart disease.

Authors+Show Affiliations

Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN55454, USA. pereira@epi.umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14980987

Citation

Pereira, Mark A., et al. "Dietary Fiber and Risk of Coronary Heart Disease: a Pooled Analysis of Cohort Studies." Archives of Internal Medicine, vol. 164, no. 4, 2004, pp. 370-6.
Pereira MA, O'Reilly E, Augustsson K, et al. Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies. Arch Intern Med. 2004;164(4):370-6.
Pereira, M. A., O'Reilly, E., Augustsson, K., Fraser, G. E., Goldbourt, U., Heitmann, B. L., ... Ascherio, A. (2004). Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies. Archives of Internal Medicine, 164(4), pp. 370-6.
Pereira MA, et al. Dietary Fiber and Risk of Coronary Heart Disease: a Pooled Analysis of Cohort Studies. Arch Intern Med. 2004 Feb 23;164(4):370-6. PubMed PMID: 14980987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies. AU - Pereira,Mark A, AU - O'Reilly,Eilis, AU - Augustsson,Katarina, AU - Fraser,Gary E, AU - Goldbourt,Uri, AU - Heitmann,Berit L, AU - Hallmans,Goran, AU - Knekt,Paul, AU - Liu,Simin, AU - Pietinen,Pirjo, AU - Spiegelman,Donna, AU - Stevens,June, AU - Virtamo,Jarmo, AU - Willett,Walter C, AU - Ascherio,Alberto, PY - 2004/2/26/pubmed PY - 2004/3/19/medline PY - 2004/2/26/entrez SP - 370 EP - 6 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 164 IS - 4 N2 - BACKGROUND: Few epidemiologic studies of dietary fiber intake and risk of coronary heart disease have compared fiber types (cereal, fruit, and vegetable) or included sex-specific results. The purpose of this study was to conduct a pooled analysis of dietary fiber and its subtypes and risk of coronary heart disease. METHODS: We analyzed the original data from 10 prospective cohort studies from the United States and Europe to estimate the association between dietary fiber intake and the risk of coronary heart disease. RESULTS: Over 6 to 10 years of follow-up, 5249 incident total coronary cases and 2011 coronary deaths occurred among 91058 men and 245186 women. After adjustment for demographics, body mass index, and lifestyle factors, each 10-g/d increment of energy-adjusted and measurement error-corrected total dietary fiber was associated with a 14% (relative risk [RR], 0.86; 95% confidence interval [CI], 0.78-0.96) decrease in risk of all coronary events and a 27% (RR, 0.73; 95% CI, 0.61-0.87) decrease in risk of coronary death. For cereal, fruit, and vegetable fiber intake (not error corrected), RRs corresponding to 10-g/d increments were 0.90 (95% CI, 0.77-1.07), 0.84 (95% CI, 0.70-0.99), and 1.00 (95% CI, 0.88-1.13), respectively, for all coronary events and 0.75 (95% CI, 0.63-0.91), 0.70 (95% CI, 0.55-0.89), and 1.00 (95% CI, 0.82-1.23), respectively, for deaths. Results were similar for men and women. CONCLUSION: Consumption of dietary fiber from cereals and fruits is inversely associated with risk of coronary heart disease. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/14980987/Dietary_fiber_and_risk_of_coronary_heart_disease:_a_pooled_analysis_of_cohort_studies_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.164.4.370 DB - PRIME DP - Unbound Medicine ER -