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In situ localization of mRNA for the fibrinolytic factors uPA, PAI-1 and uPAR in endometriotic and endometrial tissue.
Mol Hum Reprod. 2004 Mar; 10(3):159-66.MH

Abstract

Endometriotic tissue grows invasively. The plasminogen-activating system is suggested to participate in degradation of extracellular matrix (ECM) and modulation of cell adhesion and migration. We have previously demonstrated elevated levels of the fibrinolytic factors urokinase plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) in endometriotic tissue and endometrium from women with endometriosis. The aim of the present study was to localize the uPA, PAI-1 and urokinase plasminogen activator receptor (uPAR) mRNA in endometriotic tissue and in endometrium both from women with and without endometriosis. With in situ hybridization, we found that uPA mRNA seems to be up-regulated in endometriotic glands and endometrial stroma as well as PAI-1 mRNA in endometriotic and endometrial stroma from women with endometriosis. uPAR mRNA likewise appears to be up-regulated in both glands and stroma in endometriotic tissue and in endometrial glands from patients compared to endometrial glands and stroma from healthy women. These differences might be important for menstrual shedding and adherence of endometrial fragments to peritoneal lining in women developing endometriosis and for the invasive growth of endometriotic tissue.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Huddinge University Hospital, SE-141 86 Stockholm, Sweden. christine.bruse@hs.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14981142

Citation

Bruse, C, et al. "In Situ Localization of mRNA for the Fibrinolytic Factors uPA, PAI-1 and uPAR in Endometriotic and Endometrial Tissue." Molecular Human Reproduction, vol. 10, no. 3, 2004, pp. 159-66.
Bruse C, Radu D, Bergqvist A. In situ localization of mRNA for the fibrinolytic factors uPA, PAI-1 and uPAR in endometriotic and endometrial tissue. Mol Hum Reprod. 2004;10(3):159-66.
Bruse, C., Radu, D., & Bergqvist, A. (2004). In situ localization of mRNA for the fibrinolytic factors uPA, PAI-1 and uPAR in endometriotic and endometrial tissue. Molecular Human Reproduction, 10(3), 159-66.
Bruse C, Radu D, Bergqvist A. In Situ Localization of mRNA for the Fibrinolytic Factors uPA, PAI-1 and uPAR in Endometriotic and Endometrial Tissue. Mol Hum Reprod. 2004;10(3):159-66. PubMed PMID: 14981142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In situ localization of mRNA for the fibrinolytic factors uPA, PAI-1 and uPAR in endometriotic and endometrial tissue. AU - Bruse,C, AU - Radu,D, AU - Bergqvist,A, Y1 - 2004/01/29/ PY - 2004/2/26/pubmed PY - 2004/5/7/medline PY - 2004/2/26/entrez SP - 159 EP - 66 JF - Molecular human reproduction JO - Mol. Hum. Reprod. VL - 10 IS - 3 N2 - Endometriotic tissue grows invasively. The plasminogen-activating system is suggested to participate in degradation of extracellular matrix (ECM) and modulation of cell adhesion and migration. We have previously demonstrated elevated levels of the fibrinolytic factors urokinase plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) in endometriotic tissue and endometrium from women with endometriosis. The aim of the present study was to localize the uPA, PAI-1 and urokinase plasminogen activator receptor (uPAR) mRNA in endometriotic tissue and in endometrium both from women with and without endometriosis. With in situ hybridization, we found that uPA mRNA seems to be up-regulated in endometriotic glands and endometrial stroma as well as PAI-1 mRNA in endometriotic and endometrial stroma from women with endometriosis. uPAR mRNA likewise appears to be up-regulated in both glands and stroma in endometriotic tissue and in endometrial glands from patients compared to endometrial glands and stroma from healthy women. These differences might be important for menstrual shedding and adherence of endometrial fragments to peritoneal lining in women developing endometriosis and for the invasive growth of endometriotic tissue. SN - 1360-9947 UR - https://www.unboundmedicine.com/medline/citation/14981142/In_situ_localization_of_mRNA_for_the_fibrinolytic_factors_uPA_PAI_1_and_uPAR_in_endometriotic_and_endometrial_tissue_ L2 - https://academic.oup.com/molehr/article-lookup/doi/10.1093/molehr/gah033 DB - PRIME DP - Unbound Medicine ER -