Tags

Type your tag names separated by a space and hit enter

Weight cycling and the risk of developing type 2 diabetes among adult women in the United States.

Abstract

OBJECTIVE

To assess the role of weight cycling independent of BMI and weight change in predicting the risk of developing type 2 diabetes.

RESEARCH METHODS AND PROCEDURES

A six-year follow-up of 46,634 young and middle-aged women in the Nurses' Health Study II was conducted. Women who had intentionally lost > or = 20 lbs at least three times between 1989 and 1993 were classified as severe weight cyclers. Women who had intentionally lost > or = 10 lbs at least three times were classified as mild weight cyclers. The outcome was physician-diagnosed type 2 diabetes.

RESULTS

Between 1989 and 1993, approximately 20% of the women were mild weight cyclers, and 1.6% were severe weight cyclers. BMI in 1993 was positively associated with weight-cycling status (p < 0.001). During 6 years of follow-up (1993 to 1999), 418 incident cases of type 2 diabetes were documented. BMI in 1993 had a strong association with the risk of developing diabetes. Compared with women with a BMI between 17 and 22 kg/m(2), those with a BMI between 25 and 29.9 kg/m(2) were approximately seven times more likely to develop diabetes, and those with a BMI > or = 35 kg/m(2) were 63 times more likely to be diagnosed with type 2 diabetes. After adjustment for BMI, neither mild (relative risk = 1.11, 95% confidence interval, 0.89 to 1.37) nor severe (relative risk = 1.39, 95% confidence interval, 0.90 to 2.13) weight cycling predicted risk of diabetes.

DISCUSSION

Weight cycling was strongly associated with BMI, but it was not independently predictive of developing type 2 diabetes.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Alison.Field@TCH.harvard.edu

    , , , ,

    Source

    Obesity research 12:2 2004 Feb pg 267-74

    MeSH

    Adult
    Body Mass Index
    Body Weight
    Diabetes Mellitus, Type 2
    Female
    Follow-Up Studies
    Health Surveys
    Humans
    Obesity
    Proportional Hazards Models
    Risk Factors
    United States
    Weight Gain
    Weight Loss

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    14981219

    Citation

    Field, Alison E., et al. "Weight Cycling and the Risk of Developing Type 2 Diabetes Among Adult Women in the United States." Obesity Research, vol. 12, no. 2, 2004, pp. 267-74.
    Field AE, Manson JE, Laird N, et al. Weight cycling and the risk of developing type 2 diabetes among adult women in the United States. Obes Res. 2004;12(2):267-74.
    Field, A. E., Manson, J. E., Laird, N., Williamson, D. F., Willett, W. C., & Colditz, G. A. (2004). Weight cycling and the risk of developing type 2 diabetes among adult women in the United States. Obesity Research, 12(2), pp. 267-74.
    Field AE, et al. Weight Cycling and the Risk of Developing Type 2 Diabetes Among Adult Women in the United States. Obes Res. 2004;12(2):267-74. PubMed PMID: 14981219.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Weight cycling and the risk of developing type 2 diabetes among adult women in the United States. AU - Field,Alison E, AU - Manson,JoAnn E, AU - Laird,Nan, AU - Williamson,David F, AU - Willett,Walter C, AU - Colditz,Graham A, PY - 2004/2/26/pubmed PY - 2004/10/8/medline PY - 2004/2/26/entrez SP - 267 EP - 74 JF - Obesity research JO - Obes. Res. VL - 12 IS - 2 N2 - OBJECTIVE: To assess the role of weight cycling independent of BMI and weight change in predicting the risk of developing type 2 diabetes. RESEARCH METHODS AND PROCEDURES: A six-year follow-up of 46,634 young and middle-aged women in the Nurses' Health Study II was conducted. Women who had intentionally lost > or = 20 lbs at least three times between 1989 and 1993 were classified as severe weight cyclers. Women who had intentionally lost > or = 10 lbs at least three times were classified as mild weight cyclers. The outcome was physician-diagnosed type 2 diabetes. RESULTS: Between 1989 and 1993, approximately 20% of the women were mild weight cyclers, and 1.6% were severe weight cyclers. BMI in 1993 was positively associated with weight-cycling status (p < 0.001). During 6 years of follow-up (1993 to 1999), 418 incident cases of type 2 diabetes were documented. BMI in 1993 had a strong association with the risk of developing diabetes. Compared with women with a BMI between 17 and 22 kg/m(2), those with a BMI between 25 and 29.9 kg/m(2) were approximately seven times more likely to develop diabetes, and those with a BMI > or = 35 kg/m(2) were 63 times more likely to be diagnosed with type 2 diabetes. After adjustment for BMI, neither mild (relative risk = 1.11, 95% confidence interval, 0.89 to 1.37) nor severe (relative risk = 1.39, 95% confidence interval, 0.90 to 2.13) weight cycling predicted risk of diabetes. DISCUSSION: Weight cycling was strongly associated with BMI, but it was not independently predictive of developing type 2 diabetes. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/14981219/Weight_cycling_and_the_risk_of_developing_type_2_diabetes_among_adult_women_in_the_United_States_ L2 - https://doi.org/10.1038/oby.2004.34 DB - PRIME DP - Unbound Medicine ER -