Tags

Type your tag names separated by a space and hit enter

Dietary folate and vitamin B6 are independent predictors of peripheral arterial occlusive disease.
J Vasc Surg 2004; 39(3):513-6JV

Abstract

BACKGROUND

It has been suggested that hyperhomocysteinemia (HHcy) is an independent risk factor for peripheral arterial occlusive disease (PAOD). However, the relationship between dietary folate and vitamin B6, cofactors in the metabolism of homocysteine (Hcy), and PAOD is unclear.

AIMS

To study the relationship between dietary folate and B6 and PAOD.

METHODS

Case-control population based study of 392 men older than 50 years living in Huntingdon, United Kingdom. PAOD, defined as an ankle-brachial pressure index (ABPI) < 0.9, was present in 86 (22%) of subjects. Folate, vitamin B6, and vitamin B12 intakes were calculated by means of the EPIC (European Prospective Investigation into Cancer) food frequency questionnaire.

RESULTS

Daily folate intake was significantly lower in case subjects (mean, 288; 95% confidence interval [CI], 266-309 microg) than in control subjects (324; 95% CI, 313-335 microg). Daily vitamin B6 intake was also lower in case subjects (2.05; 95% CI, 1.92-2.19 mg versus 2.26; 95% CI, 2.19-2.33 mg). Daily folate and vitamin B6 intakes were independent predictors of PAOD after adjusting for age, blood pressure, cholesterol levels, diabetes, and smoking status in a logistic regression model. This model suggests that increasing daily folate intake by 1 standard deviation decreased the risk of PAOD by 46%. A similar increase in daily vitamin B6 intake decreased the risk of PAOD by 29%.

CONCLUSION

In men older than 50 years, dietary folate and B6 intakes are independent predictors of PAOD. Longitudinal studies are required to determine whether dietary modification can reduce the incidence of PAOD in the population.

Authors+Show Affiliations

University Department of Vascular Surgery, Birmingham Heartlands Hospital, University of Birmingham, Birmingham, UK. abmw100@doctors.org.uk

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14981440

Citation

Wilmink, Antonius B M., et al. "Dietary Folate and Vitamin B6 Are Independent Predictors of Peripheral Arterial Occlusive Disease." Journal of Vascular Surgery, vol. 39, no. 3, 2004, pp. 513-6.
Wilmink AB, Welch AA, Quick CR, et al. Dietary folate and vitamin B6 are independent predictors of peripheral arterial occlusive disease. J Vasc Surg. 2004;39(3):513-6.
Wilmink, A. B., Welch, A. A., Quick, C. R., Burns, P. J., Hubbard, C. S., Bradbury, A. W., & Day, N. E. (2004). Dietary folate and vitamin B6 are independent predictors of peripheral arterial occlusive disease. Journal of Vascular Surgery, 39(3), pp. 513-6.
Wilmink AB, et al. Dietary Folate and Vitamin B6 Are Independent Predictors of Peripheral Arterial Occlusive Disease. J Vasc Surg. 2004;39(3):513-6. PubMed PMID: 14981440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary folate and vitamin B6 are independent predictors of peripheral arterial occlusive disease. AU - Wilmink,Antonius B M, AU - Welch,Ailsa A, AU - Quick,Clive R G, AU - Burns,Paul J, AU - Hubbard,C S, AU - Bradbury,Andrew W, AU - Day,Nicholas E, PY - 2004/2/26/pubmed PY - 2004/3/31/medline PY - 2004/2/26/entrez SP - 513 EP - 6 JF - Journal of vascular surgery JO - J. Vasc. Surg. VL - 39 IS - 3 N2 - BACKGROUND: It has been suggested that hyperhomocysteinemia (HHcy) is an independent risk factor for peripheral arterial occlusive disease (PAOD). However, the relationship between dietary folate and vitamin B6, cofactors in the metabolism of homocysteine (Hcy), and PAOD is unclear. AIMS: To study the relationship between dietary folate and B6 and PAOD. METHODS: Case-control population based study of 392 men older than 50 years living in Huntingdon, United Kingdom. PAOD, defined as an ankle-brachial pressure index (ABPI) < 0.9, was present in 86 (22%) of subjects. Folate, vitamin B6, and vitamin B12 intakes were calculated by means of the EPIC (European Prospective Investigation into Cancer) food frequency questionnaire. RESULTS: Daily folate intake was significantly lower in case subjects (mean, 288; 95% confidence interval [CI], 266-309 microg) than in control subjects (324; 95% CI, 313-335 microg). Daily vitamin B6 intake was also lower in case subjects (2.05; 95% CI, 1.92-2.19 mg versus 2.26; 95% CI, 2.19-2.33 mg). Daily folate and vitamin B6 intakes were independent predictors of PAOD after adjusting for age, blood pressure, cholesterol levels, diabetes, and smoking status in a logistic regression model. This model suggests that increasing daily folate intake by 1 standard deviation decreased the risk of PAOD by 46%. A similar increase in daily vitamin B6 intake decreased the risk of PAOD by 29%. CONCLUSION: In men older than 50 years, dietary folate and B6 intakes are independent predictors of PAOD. Longitudinal studies are required to determine whether dietary modification can reduce the incidence of PAOD in the population. SN - 0741-5214 UR - https://www.unboundmedicine.com/medline/citation/14981440/Dietary_folate_and_vitamin_B6_are_independent_predictors_of_peripheral_arterial_occlusive_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0741521403015672 DB - PRIME DP - Unbound Medicine ER -