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Epidemiology of hepatitis A and hepatitis E infection and their determinants in adult Chinese community in Hong Kong.
J Med Virol. 2004 Apr; 72(4):538-44.JM

Abstract

Current epidemiology of hepatitis A virus (HAV) and hepatitis E virus (HEV) in Hong Kong was evaluated in 936 adult Chinese subjects recruited through a telephone interview in 2001. Some 15% of the subjects had IgG antibodies to both HAV and HEV while 665 (71.0%) and 176 (18.8%) had anti-HAV and anti-HEV, respectively. Age was the most significant independent factor. Six hundred thirty-eight (79.8%) and 165 (20.7%) subjects aged > or =30 had anti-HAV and anti-HEV, respectively, as compared with 27 (19.7%) and 11 (8.0%) in people aged <30. The corresponding adjusted Odds ratio (OR) was 14.94 (95% CI: 9.13-24.44; P<0.001) for anti-HAV positivity and 2.99 (95% CI: 1.58-5.67; P=0.001) for anti-HEV positivity. Subjects born outside Hong Kong were more likely to have anti-HAV (adjusted OR: 3.41; 95% CI: 2.21-5.26; P<0.001) but not anti-HEV. Non-labour work people were less likely to have anti-HAV-adjusted OR, 0.40 (95% CI: 0.26-0.62; P<0.001). Age-specific HAV prevalence right shifted in the last 20 years. Anti-HAV positivity was less frequent, across all age groups, in subjects >21-years-old in the present study than another study done in 1987-89 (P<0.001). HAV prevalence only increased slightly in every 10-year age groups of people aged 21-50 when compared with their corresponding 10-year-younger age groups (P=0.11), suggesting an ageing cohort effect with no major infections in the last decade. For HEV, both the overall and age-specific prevalence decreased over the last decade (P<0.001). The increasing proportion of susceptible population to enterically transmitted viral hepatitis has implications to future prevention and control programmes, including vaccination strategies.

Authors+Show Affiliations

Special Preventive Programme, Department of Health, Hong Kong Special Administrative Region, Hong Kong. khwong@dhspp.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14981755

Citation

Wong, K H., et al. "Epidemiology of Hepatitis a and Hepatitis E Infection and Their Determinants in Adult Chinese Community in Hong Kong." Journal of Medical Virology, vol. 72, no. 4, 2004, pp. 538-44.
Wong KH, Liu YM, Ng PS, et al. Epidemiology of hepatitis A and hepatitis E infection and their determinants in adult Chinese community in Hong Kong. J Med Virol. 2004;72(4):538-44.
Wong, K. H., Liu, Y. M., Ng, P. S., Young, B. W., & Lee, S. S. (2004). Epidemiology of hepatitis A and hepatitis E infection and their determinants in adult Chinese community in Hong Kong. Journal of Medical Virology, 72(4), 538-44.
Wong KH, et al. Epidemiology of Hepatitis a and Hepatitis E Infection and Their Determinants in Adult Chinese Community in Hong Kong. J Med Virol. 2004;72(4):538-44. PubMed PMID: 14981755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of hepatitis A and hepatitis E infection and their determinants in adult Chinese community in Hong Kong. AU - Wong,K H, AU - Liu,Y M, AU - Ng,P S P, AU - Young,B W Y, AU - Lee,S S, PY - 2004/2/26/pubmed PY - 2004/5/1/medline PY - 2004/2/26/entrez SP - 538 EP - 44 JF - Journal of medical virology JO - J Med Virol VL - 72 IS - 4 N2 - Current epidemiology of hepatitis A virus (HAV) and hepatitis E virus (HEV) in Hong Kong was evaluated in 936 adult Chinese subjects recruited through a telephone interview in 2001. Some 15% of the subjects had IgG antibodies to both HAV and HEV while 665 (71.0%) and 176 (18.8%) had anti-HAV and anti-HEV, respectively. Age was the most significant independent factor. Six hundred thirty-eight (79.8%) and 165 (20.7%) subjects aged > or =30 had anti-HAV and anti-HEV, respectively, as compared with 27 (19.7%) and 11 (8.0%) in people aged <30. The corresponding adjusted Odds ratio (OR) was 14.94 (95% CI: 9.13-24.44; P<0.001) for anti-HAV positivity and 2.99 (95% CI: 1.58-5.67; P=0.001) for anti-HEV positivity. Subjects born outside Hong Kong were more likely to have anti-HAV (adjusted OR: 3.41; 95% CI: 2.21-5.26; P<0.001) but not anti-HEV. Non-labour work people were less likely to have anti-HAV-adjusted OR, 0.40 (95% CI: 0.26-0.62; P<0.001). Age-specific HAV prevalence right shifted in the last 20 years. Anti-HAV positivity was less frequent, across all age groups, in subjects >21-years-old in the present study than another study done in 1987-89 (P<0.001). HAV prevalence only increased slightly in every 10-year age groups of people aged 21-50 when compared with their corresponding 10-year-younger age groups (P=0.11), suggesting an ageing cohort effect with no major infections in the last decade. For HEV, both the overall and age-specific prevalence decreased over the last decade (P<0.001). The increasing proportion of susceptible population to enterically transmitted viral hepatitis has implications to future prevention and control programmes, including vaccination strategies. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/14981755/Epidemiology_of_hepatitis_A_and_hepatitis_E_infection_and_their_determinants_in_adult_Chinese_community_in_Hong_Kong_ DB - PRIME DP - Unbound Medicine ER -