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[Expression of cyclooxygenase in bladder transitional cell carcinoma].
Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Jan; 35(1):54-6.SD

Abstract

OBJECTIVE

To evaluate the role of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in the development of bladder transitional cell carcinoma.

METHODS

Thirty-four specimens were obtained from patients with bladder transitional carcinoma, and 7 specimens of normal bladder tissues were obtained from renal transplantation donors. Immunohistochemistry and RT-PCR were performed to study the expression of COX-1 and COX-2.

RESULTS

No marked expression of COX-2 was observed in the normal bladder, but higher level of COX-2 expression was noted in the malignant cells. The extent and intensity of COX-2 expression in cancer cells were statistically greater than those in the cells from normal bladder tissue. Correlation between COX-2 expression and progression of bladder transitional cell carcinoma was observed. COX-2 expression was significantly higher in Grade 3 bladder transitional cell carcinoma than in Grades 1 and 2 (P < 0.001). There was no significant difference in COX-2 expression level between the bladder transitional cell carcinomas at different clinical stages (P > 0.05). The expression of COX-1 was seen in some bladder transitional cell carcinoma and normal bladder.

CONCLUSION

COX-2 might be of significance to the proliferation and development of bladder transitional cell carcinoma.

Authors+Show Affiliations

Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

14981815

Citation

Wang, Kun-jie, et al. "[Expression of Cyclooxygenase in Bladder Transitional Cell Carcinoma]." Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition, vol. 35, no. 1, 2004, pp. 54-6.
Wang KJ, Li H, Wei Q, et al. [Expression of cyclooxygenase in bladder transitional cell carcinoma]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2004;35(1):54-6.
Wang, K. J., Li, H., Wei, Q., & Yang, Y. R. (2004). [Expression of cyclooxygenase in bladder transitional cell carcinoma]. Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition, 35(1), 54-6.
Wang KJ, et al. [Expression of Cyclooxygenase in Bladder Transitional Cell Carcinoma]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2004;35(1):54-6. PubMed PMID: 14981815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression of cyclooxygenase in bladder transitional cell carcinoma]. AU - Wang,Kun-jie, AU - Li,Hong, AU - Wei,Qiang, AU - Yang,Yu-ru, PY - 2004/2/26/pubmed PY - 2004/7/23/medline PY - 2004/2/26/entrez SP - 54 EP - 6 JF - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition JO - Sichuan Da Xue Xue Bao Yi Xue Ban VL - 35 IS - 1 N2 - OBJECTIVE: To evaluate the role of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in the development of bladder transitional cell carcinoma. METHODS: Thirty-four specimens were obtained from patients with bladder transitional carcinoma, and 7 specimens of normal bladder tissues were obtained from renal transplantation donors. Immunohistochemistry and RT-PCR were performed to study the expression of COX-1 and COX-2. RESULTS: No marked expression of COX-2 was observed in the normal bladder, but higher level of COX-2 expression was noted in the malignant cells. The extent and intensity of COX-2 expression in cancer cells were statistically greater than those in the cells from normal bladder tissue. Correlation between COX-2 expression and progression of bladder transitional cell carcinoma was observed. COX-2 expression was significantly higher in Grade 3 bladder transitional cell carcinoma than in Grades 1 and 2 (P < 0.001). There was no significant difference in COX-2 expression level between the bladder transitional cell carcinomas at different clinical stages (P > 0.05). The expression of COX-1 was seen in some bladder transitional cell carcinoma and normal bladder. CONCLUSION: COX-2 might be of significance to the proliferation and development of bladder transitional cell carcinoma. SN - 1672-173X UR - https://www.unboundmedicine.com/medline/citation/14981815/[Expression_of_cyclooxygenase_in_bladder_transitional_cell_carcinoma]_ L2 - http://www.diseaseinfosearch.org/result/7168 DB - PRIME DP - Unbound Medicine ER -