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Role of microsatellite instability in borderline ovarian tumors.
Anticancer Res. 2003 Nov-Dec; 23(6D):5139-41.AR

Abstract

This study was designed to establish the role of microsatellite instability (MSI) in the development of sporadic tumors of the ovary. The instability of 6 microsatellites (BAT25, BAT26, NME1, D17S250, D5S346 and D2S123) was determined by comparing MSI in healthy and tumoral tissue in each of 40 patients undergoing surgery for a sporadic ovarian tumor. BAT26 and D2S123 instability was detected in borderline tumors, and ovarian carcinomas were found to present instability in the microsatellites BAT25, NME1 and D17S250. Our findings indicate that microsatellite instability lacks a significant role in the appearance or progression of sporadic ovarian tumors.

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clones/clone libraries

Authors+Show Affiliations

Sanz Casla MT
Laboratory, Biology Department, Hospital Clinico San Carlos, C/Martin Lagos s/n, 28040 Madrid, Spain.
Vidaurreta Lazaro M
No affiliation info available
Almansa de Lara I
No affiliation info available
Tresserra F
No affiliation info available
Lopez Marin L
No affiliation info available
Maestro ML
No affiliation info available
Dexeus S
No affiliation info available

MeSH

AdultAgedFemaleHumansMicrosatellite RepeatsMiddle AgedNeoplasm StagingOvarian Neoplasms

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14981979

Citation

Sanz Casla, M T., et al. "Role of Microsatellite Instability in Borderline Ovarian Tumors." Anticancer Research, vol. 23, no. 6D, 2003, pp. 5139-41.
Sanz Casla MT, Vidaurreta Lazaro M, Almansa de Lara I, et al. Role of microsatellite instability in borderline ovarian tumors. Anticancer Res. 2003;23(6D):5139-41.
Sanz Casla, M. T., Vidaurreta Lazaro, M., Almansa de Lara, I., Tresserra, F., Lopez Marin, L., Maestro, M. L., & Dexeus, S. (2003). Role of microsatellite instability in borderline ovarian tumors. Anticancer Research, 23(6D), 5139-41.
Sanz Casla MT, et al. Role of Microsatellite Instability in Borderline Ovarian Tumors. Anticancer Res. 2003 Nov-Dec;23(6D):5139-41. PubMed PMID: 14981979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of microsatellite instability in borderline ovarian tumors. AU - Sanz Casla,M T, AU - Vidaurreta Lazaro,M, AU - Almansa de Lara,I, AU - Tresserra,F, AU - Lopez Marin,L, AU - Maestro,M L, AU - Dexeus,S, PY - 2004/2/26/pubmed PY - 2004/4/6/medline PY - 2004/2/26/entrez SP - 5139 EP - 41 JF - Anticancer research JO - Anticancer Res VL - 23 IS - 6D N2 - This study was designed to establish the role of microsatellite instability (MSI) in the development of sporadic tumors of the ovary. The instability of 6 microsatellites (BAT25, BAT26, NME1, D17S250, D5S346 and D2S123) was determined by comparing MSI in healthy and tumoral tissue in each of 40 patients undergoing surgery for a sporadic ovarian tumor. BAT26 and D2S123 instability was detected in borderline tumors, and ovarian carcinomas were found to present instability in the microsatellites BAT25, NME1 and D17S250. Our findings indicate that microsatellite instability lacks a significant role in the appearance or progression of sporadic ovarian tumors. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/14981979/Role_of_microsatellite_instability_in_borderline_ovarian_tumors_ L2 - https://medlineplus.gov/ovariancancer.html DB - PRIME DP - Unbound Medicine ER -