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Effects of gabapentin on postoperative morphine consumption and pain after abdominal hysterectomy: a randomized, double-blind trial.
Acta Anaesthesiol Scand. 2004 Mar; 48(3):322-7.AA

Abstract

BACKGROUND

Preliminary clinical studies have suggested that gabapentin may produce analgesia and reduce the need for opioids in postoperative patients. The aim of the present study was to investigate the opioid-sparing and analgesic effects of gabapentin administered during the first 24 h after abdominal hysterectomy.

METHODS

In a randomized, double-blind study, 80 patients received oral gabapentin 1200 mg or placebo 1 h before surgery, followed by oral gabapentin 600 mg or placebo 8, 16 and 24 h after the initial dose. Patients received patient-controlled analgesia with morphine at doses of 2.5 mg with a lock-out time of 10 min for 24 h postoperatively. Pain was assessed on a visual analogue scale (VAS) at rest and during mobilization, nausea, somnolence and dizziness on a four-point verbal scale, and vomiting as present/not present at 2, 4, 22 and 24 h postoperatively.

RESULTS

Thirty-nine patients in the gabapentin group, and 32 patients in the placebo group completed the study. Gabapentin reduced total morphine consumption from median 63 (interquartile range 53-88) mg to 43 (28-60) mg (P < 0.001). We observed a significant inverse association between plasma levels of gabapentin at 2 h postoperatively, and morphine usage from 0 to 2 h, and from 0 to 4 h postoperatively (R2 = 0.30, P = 0.003 and R2 = 0.24 P = 0.008, respectively). No significant differences in pain at rest or during mobilization, or in side-effects, were observed between groups.

CONCLUSION

Gabapentin in a total dose of 3000 mg, administered before and during the first 24 h after abdominal hysterectomy, reduced morphine consumption with 32%, without significant effects on pain scores. No significant differences in side-effects were observed between study-groups.

Authors+Show Affiliations

Department of Anaesthesiology, Glostrup University Hospital, Glostrup, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

14982565

Citation

Dierking, G, et al. "Effects of Gabapentin On Postoperative Morphine Consumption and Pain After Abdominal Hysterectomy: a Randomized, Double-blind Trial." Acta Anaesthesiologica Scandinavica, vol. 48, no. 3, 2004, pp. 322-7.
Dierking G, Duedahl TH, Rasmussen ML, et al. Effects of gabapentin on postoperative morphine consumption and pain after abdominal hysterectomy: a randomized, double-blind trial. Acta Anaesthesiol Scand. 2004;48(3):322-7.
Dierking, G., Duedahl, T. H., Rasmussen, M. L., Fomsgaard, J. S., Møiniche, S., Rømsing, J., & Dahl, J. B. (2004). Effects of gabapentin on postoperative morphine consumption and pain after abdominal hysterectomy: a randomized, double-blind trial. Acta Anaesthesiologica Scandinavica, 48(3), 322-7.
Dierking G, et al. Effects of Gabapentin On Postoperative Morphine Consumption and Pain After Abdominal Hysterectomy: a Randomized, Double-blind Trial. Acta Anaesthesiol Scand. 2004;48(3):322-7. PubMed PMID: 14982565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of gabapentin on postoperative morphine consumption and pain after abdominal hysterectomy: a randomized, double-blind trial. AU - Dierking,G, AU - Duedahl,T H, AU - Rasmussen,M L, AU - Fomsgaard,J S, AU - Møiniche,S, AU - Rømsing,J, AU - Dahl,J B, PY - 2004/2/26/pubmed PY - 2004/6/23/medline PY - 2004/2/26/entrez SP - 322 EP - 7 JF - Acta anaesthesiologica Scandinavica JO - Acta Anaesthesiol Scand VL - 48 IS - 3 N2 - BACKGROUND: Preliminary clinical studies have suggested that gabapentin may produce analgesia and reduce the need for opioids in postoperative patients. The aim of the present study was to investigate the opioid-sparing and analgesic effects of gabapentin administered during the first 24 h after abdominal hysterectomy. METHODS: In a randomized, double-blind study, 80 patients received oral gabapentin 1200 mg or placebo 1 h before surgery, followed by oral gabapentin 600 mg or placebo 8, 16 and 24 h after the initial dose. Patients received patient-controlled analgesia with morphine at doses of 2.5 mg with a lock-out time of 10 min for 24 h postoperatively. Pain was assessed on a visual analogue scale (VAS) at rest and during mobilization, nausea, somnolence and dizziness on a four-point verbal scale, and vomiting as present/not present at 2, 4, 22 and 24 h postoperatively. RESULTS: Thirty-nine patients in the gabapentin group, and 32 patients in the placebo group completed the study. Gabapentin reduced total morphine consumption from median 63 (interquartile range 53-88) mg to 43 (28-60) mg (P < 0.001). We observed a significant inverse association between plasma levels of gabapentin at 2 h postoperatively, and morphine usage from 0 to 2 h, and from 0 to 4 h postoperatively (R2 = 0.30, P = 0.003 and R2 = 0.24 P = 0.008, respectively). No significant differences in pain at rest or during mobilization, or in side-effects, were observed between groups. CONCLUSION: Gabapentin in a total dose of 3000 mg, administered before and during the first 24 h after abdominal hysterectomy, reduced morphine consumption with 32%, without significant effects on pain scores. No significant differences in side-effects were observed between study-groups. SN - 0001-5172 UR - https://www.unboundmedicine.com/medline/citation/14982565/Effects_of_gabapentin_on_postoperative_morphine_consumption_and_pain_after_abdominal_hysterectomy:_a_randomized_double_blind_trial_ L2 - https://doi.org/10.1111/j.0001-5172.2004.0329.x DB - PRIME DP - Unbound Medicine ER -