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Relationship between 25-(OH) D3, the IGF-I system, leptin, anthropometric and body composition variables in a healthy, randomly selected population.

Abstract

OBJECTIVE

This study prompted us to investigate the relationship between 25-(OH) D (3) and the IGF-I system, leptin, sex, age, anthropometric and body composition variables in healthy adults. We hypothesised that these variables would regulate 25-(OH) D (3) concentrations.

DESIGN

We included 253 subjects--126 men and 127 women. Body mass index (BMI) and body composition was determined, along with serum leptin, total IGF-I, free IGF-I, IGFBP3 and plasma 25-(OH) D (3) concentrations.

RESULTS

25-(OH) D (3) deficiency was observed in 69 subjects. There was a difference between 25-(OH) D (3) values and season (summer vs. winter). We observed similar 25-(OH) D (3) concentrations in men to those in women. The differential characteristics in subjects without 25-(OH) D (3) deficiency were lower BMI, fat mass and body fat and higher free IGF-I. We observed that leptin increased in the last decades and IGF-I system decreased by decade in both men and women. In subjects without 25-(OH) D (3) deficiency, there was a correlation between free IGF-I and 25-(OH) D (3) in men, and a negative correlation between 25-(OH) D (3) and age, BMI, fat mass and leptin and a positive correlation with total IGF-I in women. The multivariate linear regression analysis explained 37.8 % of 25-(OH) D (3) variability in men and 39 % in women, and only season and free IGF-I made an independent contribution to 25-(OH) D (3) in men, and season and fat mass in women.

CONCLUSION

These data suggest that free IGF-I in men and fat mass in women could regulate 25-(OH) D (3) concentrations.

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  • Authors+Show Affiliations

    ,

    Endocrinology Service and Hormonal Laboratory, Hospital Clínic, Barcelona, Spain. jmgs@csub.scs.es

    , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aging
    Anthropometry
    Body Composition
    Body Constitution
    Body Mass Index
    Calcifediol
    Female
    Humans
    Insulin-Like Growth Factor I
    Leptin
    Logistic Models
    Male
    Middle Aged
    Seasons
    Sex Characteristics

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14983407

    Citation

    Gómez, J M., et al. "Relationship Between 25-(OH) D3, the IGF-I System, Leptin, Anthropometric and Body Composition Variables in a Healthy, Randomly Selected Population." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 36, no. 1, 2004, pp. 48-53.
    Gómez JM, Maravall FJ, Gómez N, et al. Relationship between 25-(OH) D3, the IGF-I system, leptin, anthropometric and body composition variables in a healthy, randomly selected population. Horm Metab Res. 2004;36(1):48-53.
    Gómez, J. M., Maravall, F. J., Gómez, N., Navarro, M. A., Casamitjana, R., & Soler, J. (2004). Relationship between 25-(OH) D3, the IGF-I system, leptin, anthropometric and body composition variables in a healthy, randomly selected population. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 36(1), pp. 48-53.
    Gómez JM, et al. Relationship Between 25-(OH) D3, the IGF-I System, Leptin, Anthropometric and Body Composition Variables in a Healthy, Randomly Selected Population. Horm Metab Res. 2004;36(1):48-53. PubMed PMID: 14983407.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Relationship between 25-(OH) D3, the IGF-I system, leptin, anthropometric and body composition variables in a healthy, randomly selected population. AU - Gómez,J M, AU - Maravall,F J, AU - Gómez,N, AU - Navarro,M A, AU - Casamitjana,R, AU - Soler,J, PY - 2004/2/26/pubmed PY - 2004/9/24/medline PY - 2004/2/26/entrez SP - 48 EP - 53 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 36 IS - 1 N2 - OBJECTIVE: This study prompted us to investigate the relationship between 25-(OH) D (3) and the IGF-I system, leptin, sex, age, anthropometric and body composition variables in healthy adults. We hypothesised that these variables would regulate 25-(OH) D (3) concentrations. DESIGN: We included 253 subjects--126 men and 127 women. Body mass index (BMI) and body composition was determined, along with serum leptin, total IGF-I, free IGF-I, IGFBP3 and plasma 25-(OH) D (3) concentrations. RESULTS: 25-(OH) D (3) deficiency was observed in 69 subjects. There was a difference between 25-(OH) D (3) values and season (summer vs. winter). We observed similar 25-(OH) D (3) concentrations in men to those in women. The differential characteristics in subjects without 25-(OH) D (3) deficiency were lower BMI, fat mass and body fat and higher free IGF-I. We observed that leptin increased in the last decades and IGF-I system decreased by decade in both men and women. In subjects without 25-(OH) D (3) deficiency, there was a correlation between free IGF-I and 25-(OH) D (3) in men, and a negative correlation between 25-(OH) D (3) and age, BMI, fat mass and leptin and a positive correlation with total IGF-I in women. The multivariate linear regression analysis explained 37.8 % of 25-(OH) D (3) variability in men and 39 % in women, and only season and free IGF-I made an independent contribution to 25-(OH) D (3) in men, and season and fat mass in women. CONCLUSION: These data suggest that free IGF-I in men and fat mass in women could regulate 25-(OH) D (3) concentrations. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/14983407/Relationship_between_25__OH__D3_the_IGF_I_system_leptin_anthropometric_and_body_composition_variables_in_a_healthy_randomly_selected_population_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-814103 DB - PRIME DP - Unbound Medicine ER -