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Effects of once-a-week or daily folic acid supplementation on red blood cell folate concentrations in women.
Eur J Clin Nutr. 2004 Mar; 58(3):548-54.EJ

Abstract

OBJECTIVE

Our aim was to determine if a once-a-week folic acid supplement increases women's red blood cell folate to concentrations (>905 nmol/l) that are associated with a low risk of bearing a child with a neural tube defect.

DESIGN

Randomized control trial.

SETTING

General community.

SUBJECTS

In total, 114 nonpregnant women (18-40 y) volunteers, with red blood cell folate concentrations between 295 and 905 nmol/l at screening.

INTERVENTION

Women were randomized to receive a once-a-week 2800 microg folic acid supplement, a daily 400 microg folic acid supplement or a daily placebo for 12 weeks.

RESULTS

The mean (95% CI) red blood cell folate concentrations increased during the 12-week intervention from 608 (553-668) to 900 (828-978) in the weekly folic acid group (P<0.05) and from 615 (560-677) to 1053 (957-1158) nmol/l in the daily group (P<0.05) during the trial. At week 12, 49% of women ingesting the weekly folic acid supplement had red blood cell folate concentrations greater than 905 nmol/l compared to 74% of women ingesting the daily supplement.

CONCLUSION

A once-a-week 2800 microg folic acid supplement can increase women's red blood cell folate to concentrations associated with a reduced risk of bearing a child with a neural tube defect, but is less effective than a 400 microg daily supplement. Use of a weekly folic acid supplement over at least 12 weeks before conception by women of child-bearing age may prevent neural tube defects.

FUNDING

The Otago Medical Research Foundation (Laurenson Award). Healtheries (New Zealand) provided the supplements.

Authors+Show Affiliations

Department of Human Nutrition, University of Otago, Dunedin, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

14985695

Citation

Norsworthy, B, et al. "Effects of Once-a-week or Daily Folic Acid Supplementation On Red Blood Cell Folate Concentrations in Women." European Journal of Clinical Nutrition, vol. 58, no. 3, 2004, pp. 548-54.
Norsworthy B, Skeaff CM, Adank C, et al. Effects of once-a-week or daily folic acid supplementation on red blood cell folate concentrations in women. Eur J Clin Nutr. 2004;58(3):548-54.
Norsworthy, B., Skeaff, C. M., Adank, C., & Green, T. J. (2004). Effects of once-a-week or daily folic acid supplementation on red blood cell folate concentrations in women. European Journal of Clinical Nutrition, 58(3), 548-54.
Norsworthy B, et al. Effects of Once-a-week or Daily Folic Acid Supplementation On Red Blood Cell Folate Concentrations in Women. Eur J Clin Nutr. 2004;58(3):548-54. PubMed PMID: 14985695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of once-a-week or daily folic acid supplementation on red blood cell folate concentrations in women. AU - Norsworthy,B, AU - Skeaff,C M, AU - Adank,C, AU - Green,T J, PY - 2004/2/27/pubmed PY - 2004/6/30/medline PY - 2004/2/27/entrez SP - 548 EP - 54 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 58 IS - 3 N2 - OBJECTIVE: Our aim was to determine if a once-a-week folic acid supplement increases women's red blood cell folate to concentrations (>905 nmol/l) that are associated with a low risk of bearing a child with a neural tube defect. DESIGN: Randomized control trial. SETTING: General community. SUBJECTS: In total, 114 nonpregnant women (18-40 y) volunteers, with red blood cell folate concentrations between 295 and 905 nmol/l at screening. INTERVENTION: Women were randomized to receive a once-a-week 2800 microg folic acid supplement, a daily 400 microg folic acid supplement or a daily placebo for 12 weeks. RESULTS: The mean (95% CI) red blood cell folate concentrations increased during the 12-week intervention from 608 (553-668) to 900 (828-978) in the weekly folic acid group (P<0.05) and from 615 (560-677) to 1053 (957-1158) nmol/l in the daily group (P<0.05) during the trial. At week 12, 49% of women ingesting the weekly folic acid supplement had red blood cell folate concentrations greater than 905 nmol/l compared to 74% of women ingesting the daily supplement. CONCLUSION: A once-a-week 2800 microg folic acid supplement can increase women's red blood cell folate to concentrations associated with a reduced risk of bearing a child with a neural tube defect, but is less effective than a 400 microg daily supplement. Use of a weekly folic acid supplement over at least 12 weeks before conception by women of child-bearing age may prevent neural tube defects. FUNDING: The Otago Medical Research Foundation (Laurenson Award). Healtheries (New Zealand) provided the supplements. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/14985695/Effects_of_once_a_week_or_daily_folic_acid_supplementation_on_red_blood_cell_folate_concentrations_in_women_ L2 - https://doi.org/10.1038/sj.ejcn.1601843 DB - PRIME DP - Unbound Medicine ER -