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[Apolipoprotein E gene polymorphisms and Alzheimer disease].
Yi Chuan Xue Bao 2003; 30(12):1167-70YC

Abstract

PCR-RFLP was used to investigate the distribution differences of apolipoprotein E (APOE) alleles and genotypes between sporadic Alzheimer disease (AD) patients (n = 160) and healthy control individuals (n = 195) in Chinese Han population. The results showed that the allelic frequencies of APOE epsilon 2, epsilon 3 and epsilon 4 were 0.056, 0.713 and 0.231 in AD group respectively, and 0.082, 0.844 and 0.074 in control group respectively. The frequency of epsilon 4 allele was significantly higher in AD cases than in control subjects and epsilon 4 allele was associated with AD by an odds ratio (OR) of 3.82 (chi 2 = 28.70, P < 0.001). The probability for APOE epsilon 4-carriers to suffer from AD after 65 years old was 5.38 times of that for APOE epsilon 4 non-carriers (chi 2 = 29.76, P < 0.001), suggesting that age might affect the interaction between APOE epsilon 4 and AD. In addition, our results showed that the distributions of APOE alleles and genotypes were comparable among mild, moderate and severe dementia patients (P > 0.05), suggesting that APOE gene polymorphism was not likely to contribute to dementia severity of AD patients. The frequency of APOE epsilon 4 genotype in female patients was higher than that in male patients(43.0% vs. 36.5%) and females carrying APOE epsilon 4 allele had higher OR value than corresponding males (4.3 vs. 3.3), but the differences were not statistically significant (P > 0.05). As to epsilon 2 allele, its frequency was significantly lower in male subgroup than in female subgroup of AD patients and also than in male subgroup of normal control (P < 0.05), suggesting that epsilon 2 allele was possibly an AD protective factor in Chinese male population.

Authors+Show Affiliations

National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

14986436

Citation

Chen, Deng, et al. "[Apolipoprotein E Gene Polymorphisms and Alzheimer Disease]." Yi Chuan Xue Bao = Acta Genetica Sinica, vol. 30, no. 12, 2003, pp. 1167-70.
Chen D, Zhang JW, Zhang ZX, et al. [Apolipoprotein E gene polymorphisms and Alzheimer disease]. Yi Chuan Xue Bao. 2003;30(12):1167-70.
Chen, D., Zhang, J. W., Zhang, Z. X., Zhao, H. L., Li, X. Q., Wu, Y. N., & Qu, Q. M. (2003). [Apolipoprotein E gene polymorphisms and Alzheimer disease]. Yi Chuan Xue Bao = Acta Genetica Sinica, 30(12), pp. 1167-70.
Chen D, et al. [Apolipoprotein E Gene Polymorphisms and Alzheimer Disease]. Yi Chuan Xue Bao. 2003;30(12):1167-70. PubMed PMID: 14986436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Apolipoprotein E gene polymorphisms and Alzheimer disease]. AU - Chen,Deng, AU - Zhang,Jun-Wu, AU - Zhang,Zhen-Xin, AU - Zhao,Hua-Lu, AU - Li,Xiao-Qing, AU - Wu,Ya-Ning, AU - Qu,Qiu-Ming, PY - 2004/2/28/pubmed PY - 2004/4/23/medline PY - 2004/2/28/entrez SP - 1167 EP - 70 JF - Yi chuan xue bao = Acta genetica Sinica JO - Yi Chuan Xue Bao VL - 30 IS - 12 N2 - PCR-RFLP was used to investigate the distribution differences of apolipoprotein E (APOE) alleles and genotypes between sporadic Alzheimer disease (AD) patients (n = 160) and healthy control individuals (n = 195) in Chinese Han population. The results showed that the allelic frequencies of APOE epsilon 2, epsilon 3 and epsilon 4 were 0.056, 0.713 and 0.231 in AD group respectively, and 0.082, 0.844 and 0.074 in control group respectively. The frequency of epsilon 4 allele was significantly higher in AD cases than in control subjects and epsilon 4 allele was associated with AD by an odds ratio (OR) of 3.82 (chi 2 = 28.70, P < 0.001). The probability for APOE epsilon 4-carriers to suffer from AD after 65 years old was 5.38 times of that for APOE epsilon 4 non-carriers (chi 2 = 29.76, P < 0.001), suggesting that age might affect the interaction between APOE epsilon 4 and AD. In addition, our results showed that the distributions of APOE alleles and genotypes were comparable among mild, moderate and severe dementia patients (P > 0.05), suggesting that APOE gene polymorphism was not likely to contribute to dementia severity of AD patients. The frequency of APOE epsilon 4 genotype in female patients was higher than that in male patients(43.0% vs. 36.5%) and females carrying APOE epsilon 4 allele had higher OR value than corresponding males (4.3 vs. 3.3), but the differences were not statistically significant (P > 0.05). As to epsilon 2 allele, its frequency was significantly lower in male subgroup than in female subgroup of AD patients and also than in male subgroup of normal control (P < 0.05), suggesting that epsilon 2 allele was possibly an AD protective factor in Chinese male population. SN - 0379-4172 UR - https://www.unboundmedicine.com/medline/citation/14986436/[Apolipoprotein_E_gene_polymorphisms_and_Alzheimer_disease]_ L2 - http://www.diseaseinfosearch.org/result/349 DB - PRIME DP - Unbound Medicine ER -