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[Study on the pharmacokinetics and bioavailability of syringic acid in rabbits].
Zhong Yao Cai. 2003 Nov; 26(11):798-801.ZY

Abstract

OBJECTIVE

To study the pharmacokinetics and bioavailability of syringic acid(SA) in rabbits by HPLC.

METHOD

After the rabbits were injected SA injection via ear vein and peritoneal cavity, blood was collected also via ear vein at different time-point. Then the concentration of SA in blood was determined by HPLC and the concentration-time curve was mapped to simulate a compartment model. So the pharmacokinetic parameters were calculated out. Several days after this injection, the drug was administered to the rabbits via i.p. and using the same method, another concentration-time curve was obtained. By comparing the AUC of the two curves, bioavailability was obtained.

RESULTS

The concentration-time curve of SA in rabbits after i.v. fitted in a two-compartment open model and the absolute bioavailability was 86.27%.

CONCLUSION

The results were valuable for the clinical application of new anti-endotoxic drug from Radix Isatidis.

Authors+Show Affiliations

Liu Y
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030.
Guo X
No affiliation info available
Lü Z
No affiliation info available
Xie W
No affiliation info available

MeSH

AnimalsBiological AvailabilityChromatography, High Pressure LiquidDrugs, Chinese HerbalFemaleGallic AcidInjections, IntraperitonealInjections, IntravenousIsatisMalePlant RootsPlants, MedicinalRabbitsTime Factors

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

14989061

Citation

Liu, Yunhai, et al. "[Study On the Pharmacokinetics and Bioavailability of Syringic Acid in Rabbits]." Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, vol. 26, no. 11, 2003, pp. 798-801.
Liu Y, Guo X, Lü Z, et al. [Study on the pharmacokinetics and bioavailability of syringic acid in rabbits]. Zhong Yao Cai. 2003;26(11):798-801.
Liu, Y., Guo, X., Lü, Z., & Xie, W. (2003). [Study on the pharmacokinetics and bioavailability of syringic acid in rabbits]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, 26(11), 798-801.
Liu Y, et al. [Study On the Pharmacokinetics and Bioavailability of Syringic Acid in Rabbits]. Zhong Yao Cai. 2003;26(11):798-801. PubMed PMID: 14989061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on the pharmacokinetics and bioavailability of syringic acid in rabbits]. AU - Liu,Yunhai, AU - Guo,Xianxi, AU - Lü,Zhengsong, AU - Xie,Wei, PY - 2004/3/3/pubmed PY - 2004/5/20/medline PY - 2004/3/3/entrez SP - 798 EP - 801 JF - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials JO - Zhong Yao Cai VL - 26 IS - 11 N2 - OBJECTIVE: To study the pharmacokinetics and bioavailability of syringic acid(SA) in rabbits by HPLC. METHOD: After the rabbits were injected SA injection via ear vein and peritoneal cavity, blood was collected also via ear vein at different time-point. Then the concentration of SA in blood was determined by HPLC and the concentration-time curve was mapped to simulate a compartment model. So the pharmacokinetic parameters were calculated out. Several days after this injection, the drug was administered to the rabbits via i.p. and using the same method, another concentration-time curve was obtained. By comparing the AUC of the two curves, bioavailability was obtained. RESULTS: The concentration-time curve of SA in rabbits after i.v. fitted in a two-compartment open model and the absolute bioavailability was 86.27%. CONCLUSION: The results were valuable for the clinical application of new anti-endotoxic drug from Radix Isatidis. SN - 1001-4454 UR - https://www.unboundmedicine.com/medline/citation/14989061/[Study_on_the_pharmacokinetics_and_bioavailability_of_syringic_acid_in_rabbits]_ DB - PRIME DP - Unbound Medicine ER -