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[Postexposure prophylaxis after occupational exposure to HBV, HCV and HIV].
Radiologe. 2004 Feb; 44(2):181-94.R

Abstract

After occupational exposure to HBV, HCV, and HIV, the patient from whom the potentially infectious material originates (index patient) as well as the exposed person should undergo serological and, if needed, molecular screening. Active and passive immunoprophylaxis after exposure to HBV is an effective tool against infection with hepatitis B virus in unvaccinated persons. The post-exposure prophylaxis (PEP) should be given within 24 h after exposure of an unprotected person to HBV-positive material. Once acute hepatitis B infection is diagnosed, therapy is not recommended for immunocompetent persons. At present, PEP against HCV infection is not available. Monotherapy with interferon-alpha avoids chronification in most patients suffering from acute hepatitis C. After exposure with an increased risk for transmission of HIV (percutaneous needle stick injury, cut), PEP should be recommended and can also be offered for further indications. PEP should be started as early as possible and carried out for 28 days. The recommended PEP consists of two inhibitors of the reverse transcriptase and one inhibitor of the protease.

Authors+Show Affiliations

Klinik und Poliklinik für Innere Medizin, Universitätskliniken des Saarlandes, Homburg/Saar, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

14991139

Citation

Sarrazin, U, et al. "[Postexposure Prophylaxis After Occupational Exposure to HBV, HCV and HIV]." Der Radiologe, vol. 44, no. 2, 2004, pp. 181-94.
Sarrazin U, Brodt R, Sarrazin C, et al. [Postexposure prophylaxis after occupational exposure to HBV, HCV and HIV]. Radiologe. 2004;44(2):181-94.
Sarrazin, U., Brodt, R., Sarrazin, C., & Zeuzem, S. (2004). [Postexposure prophylaxis after occupational exposure to HBV, HCV and HIV]. Der Radiologe, 44(2), 181-94.
Sarrazin U, et al. [Postexposure Prophylaxis After Occupational Exposure to HBV, HCV and HIV]. Radiologe. 2004;44(2):181-94. PubMed PMID: 14991139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Postexposure prophylaxis after occupational exposure to HBV, HCV and HIV]. AU - Sarrazin,U, AU - Brodt,R, AU - Sarrazin,C, AU - Zeuzem,S, PY - 2004/3/3/pubmed PY - 2004/7/9/medline PY - 2004/3/3/entrez SP - 181 EP - 94 JF - Der Radiologe JO - Radiologe VL - 44 IS - 2 N2 - After occupational exposure to HBV, HCV, and HIV, the patient from whom the potentially infectious material originates (index patient) as well as the exposed person should undergo serological and, if needed, molecular screening. Active and passive immunoprophylaxis after exposure to HBV is an effective tool against infection with hepatitis B virus in unvaccinated persons. The post-exposure prophylaxis (PEP) should be given within 24 h after exposure of an unprotected person to HBV-positive material. Once acute hepatitis B infection is diagnosed, therapy is not recommended for immunocompetent persons. At present, PEP against HCV infection is not available. Monotherapy with interferon-alpha avoids chronification in most patients suffering from acute hepatitis C. After exposure with an increased risk for transmission of HIV (percutaneous needle stick injury, cut), PEP should be recommended and can also be offered for further indications. PEP should be started as early as possible and carried out for 28 days. The recommended PEP consists of two inhibitors of the reverse transcriptase and one inhibitor of the protease. SN - 0033-832X UR - https://www.unboundmedicine.com/medline/citation/14991139/[Postexposure_prophylaxis_after_occupational_exposure_to_HBV_HCV_and_HIV]_ L2 - https://dx.doi.org/10.1007/s00117-004-1022-z DB - PRIME DP - Unbound Medicine ER -