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Current concepts in SARS treatment.
J Infect Chemother. 2004 Feb; 10(1):1-7.JI

Abstract

The outbreak of severe acute respiratory syndrome (SARS) has drawn enormous attention and caused fear worldwide since early 2003. The disease appears to be under control now; however, the possible return of SARS must be emphasized. Although many clinical experiments have been reported, the treatment of SARS is largely anecdotal, and so far no treatment consensus has been reached. We summarize 14 clinical reports and attempt to assess the effectiveness of various treatment regimens. A combination treatment of steroids and ribavirin was widely used empirically from the outset of the epidemic. In general, the use of steroids for SARS seemed beneficial, but the optimal timing, dosage, and duration of treatment have not yet been determined. On the other hand, ribavirin administration apparently reduced neither the rate of intratracheal intubation nor that of mortality. Moreover, significant toxicity, such as hemolytic anemia, has been attributed to ribavirin. A few preliminary trials and in vitro data suggest the possibility of treating SARS with interferon. Other agents, including the HIV protease inhibitor glycyrrhizin and convalescent plasma, remain to be evaluated.

Authors+Show Affiliations

Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Japan. tmks@ims.u-tokyo.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

14991510

Citation

Fujii, Takeshi, et al. "Current Concepts in SARS Treatment." Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, vol. 10, no. 1, 2004, pp. 1-7.
Fujii T, Nakamura T, Iwamoto A. Current concepts in SARS treatment. J Infect Chemother. 2004;10(1):1-7.
Fujii, T., Nakamura, T., & Iwamoto, A. (2004). Current concepts in SARS treatment. Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, 10(1), 1-7.
Fujii T, Nakamura T, Iwamoto A. Current Concepts in SARS Treatment. J Infect Chemother. 2004;10(1):1-7. PubMed PMID: 14991510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current concepts in SARS treatment. AU - Fujii,Takeshi, AU - Nakamura,Tetsuya, AU - Iwamoto,Aikichi, PY - 2003/12/16/received PY - 2004/3/3/pubmed PY - 2004/4/9/medline PY - 2004/3/3/entrez SP - 1 EP - 7 JF - Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy JO - J Infect Chemother VL - 10 IS - 1 N2 - The outbreak of severe acute respiratory syndrome (SARS) has drawn enormous attention and caused fear worldwide since early 2003. The disease appears to be under control now; however, the possible return of SARS must be emphasized. Although many clinical experiments have been reported, the treatment of SARS is largely anecdotal, and so far no treatment consensus has been reached. We summarize 14 clinical reports and attempt to assess the effectiveness of various treatment regimens. A combination treatment of steroids and ribavirin was widely used empirically from the outset of the epidemic. In general, the use of steroids for SARS seemed beneficial, but the optimal timing, dosage, and duration of treatment have not yet been determined. On the other hand, ribavirin administration apparently reduced neither the rate of intratracheal intubation nor that of mortality. Moreover, significant toxicity, such as hemolytic anemia, has been attributed to ribavirin. A few preliminary trials and in vitro data suggest the possibility of treating SARS with interferon. Other agents, including the HIV protease inhibitor glycyrrhizin and convalescent plasma, remain to be evaluated. SN - 1341-321X UR - https://www.unboundmedicine.com/medline/citation/14991510/Current_concepts_in_SARS_treatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1341-321X(04)71089-2 DB - PRIME DP - Unbound Medicine ER -