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Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo.
Eur J Immunol. 2004 Mar; 34(3):743-751.EJ

Abstract

4-1BBL(-/-) mice have a defect in recall CD8+ T cell responses to viruses, whereas CD4+ T cell responses to virus are unimpaired in these mice. In contrast, both CD4+ and CD8+ T cells respond to 4-1BB ligand (4-1BBL) in vitro. To clarify the role of 4-1BB/4-1BBL in CD4+ versus CD8+ T cell responses in vivo, we compared CD4 (OT-II) and CD8 (OT-I) TCR transgenic T cells responding to the same antigen in an in vivo adoptive transfer model in 4-1BBL(+/+) versus 4-1BBL(-/-) mice. During primary and secondary responses, expression of 4-1BB on in vivo-activated TCR transgenic T cells was earlier and more transient than previously observed in vitro, correlating with expression of the early activation antigen CD69 and preceding the transition to the CD44hi state. Although 4-1BB is expressed early in the primary response, there was no effect of 4-1BBL deficiency on initial CD8 T cell expansion and only a minor effect on initial CD4 T cell expansion. The major effect of 4-1BB/4-1BBL interaction is on the T cell recall response. This is due to effects of 4-1BBL on maintenance of T cell numbers at the end of the primary response with additional effects of 4-1BBL on secondary expansion of T cells.

Authors+Show Affiliations

Department of Immunology, University of Toronto, Toronto, Canada.Department of Immunology, University of Toronto, Toronto, Canada.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14991604

Citation

Dawicki, Wojciech, and Tania H. Watts. "Expression and Function of 4-1BB During CD4 Versus CD8 T Cell Responses in Vivo." European Journal of Immunology, vol. 34, no. 3, 2004, pp. 743-751.
Dawicki W, Watts TH. Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo. Eur J Immunol. 2004;34(3):743-751.
Dawicki, W., & Watts, T. H. (2004). Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo. European Journal of Immunology, 34(3), 743-751. https://doi.org/10.1002/eji.200324278
Dawicki W, Watts TH. Expression and Function of 4-1BB During CD4 Versus CD8 T Cell Responses in Vivo. Eur J Immunol. 2004;34(3):743-751. PubMed PMID: 14991604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo. AU - Dawicki,Wojciech, AU - Watts,Tania H, PY - 2004/3/3/pubmed PY - 2004/3/26/medline PY - 2004/3/3/entrez SP - 743 EP - 751 JF - European journal of immunology JO - Eur. J. Immunol. VL - 34 IS - 3 N2 - 4-1BBL(-/-) mice have a defect in recall CD8+ T cell responses to viruses, whereas CD4+ T cell responses to virus are unimpaired in these mice. In contrast, both CD4+ and CD8+ T cells respond to 4-1BB ligand (4-1BBL) in vitro. To clarify the role of 4-1BB/4-1BBL in CD4+ versus CD8+ T cell responses in vivo, we compared CD4 (OT-II) and CD8 (OT-I) TCR transgenic T cells responding to the same antigen in an in vivo adoptive transfer model in 4-1BBL(+/+) versus 4-1BBL(-/-) mice. During primary and secondary responses, expression of 4-1BB on in vivo-activated TCR transgenic T cells was earlier and more transient than previously observed in vitro, correlating with expression of the early activation antigen CD69 and preceding the transition to the CD44hi state. Although 4-1BB is expressed early in the primary response, there was no effect of 4-1BBL deficiency on initial CD8 T cell expansion and only a minor effect on initial CD4 T cell expansion. The major effect of 4-1BB/4-1BBL interaction is on the T cell recall response. This is due to effects of 4-1BBL on maintenance of T cell numbers at the end of the primary response with additional effects of 4-1BBL on secondary expansion of T cells. SN - 0014-2980 UR - https://www.unboundmedicine.com/medline/citation/14991604/Expression_and_function_of_4_1BB_during_CD4_versus_CD8_T_cell_responses_in_vivo_ L2 - https://doi.org/10.1002/eji.200324278 DB - PRIME DP - Unbound Medicine ER -