Tags

Type your tag names separated by a space and hit enter

CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease.
Ann Neurol. 2004 Mar; 55(3):430-4.AN

Abstract

We performed a case-control study of Parkinson's disease (PD) in a population characterized by a high prevalence of pesticide exposure and studied the joint effect of pesticide exposure and CYP2D6. Although they are based on a small group of subjects with the joint exposure, our findings are consistent with a gene-environment interaction disease model according to which (1) pesticides have a modest effect in subjects who are not CYP2D6 poor metabolizers, (2) pesticides' effect is increased in poor metabolizers (approximately twofold), and (3) poor metabolizers are not at increased PD risk in the absence of pesticide exposure.

Authors+Show Affiliations

National Institute of Health and Medical Research (INSERM) Unit 360, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13, France. elbaz@chups,jussieu.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14991823

Citation

Elbaz, Alexis, et al. "CYP2D6 Polymorphism, Pesticide Exposure, and Parkinson's Disease." Annals of Neurology, vol. 55, no. 3, 2004, pp. 430-4.
Elbaz A, Levecque C, Clavel J, et al. CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease. Ann Neurol. 2004;55(3):430-4.
Elbaz, A., Levecque, C., Clavel, J., Vidal, J. S., Richard, F., Amouyel, P., Alpérovitch, A., Chartier-Harlin, M. C., & Tzourio, C. (2004). CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease. Annals of Neurology, 55(3), 430-4.
Elbaz A, et al. CYP2D6 Polymorphism, Pesticide Exposure, and Parkinson's Disease. Ann Neurol. 2004;55(3):430-4. PubMed PMID: 14991823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease. AU - Elbaz,Alexis, AU - Levecque,Clotilde, AU - Clavel,Jacqueline, AU - Vidal,Jean-Sébastien, AU - Richard,Florence, AU - Amouyel,Philippe, AU - Alpérovitch,Annick, AU - Chartier-Harlin,Marie-Christine, AU - Tzourio,Christophe, PY - 2004/3/3/pubmed PY - 2004/4/13/medline PY - 2004/3/3/entrez SP - 430 EP - 4 JF - Annals of neurology JO - Ann. Neurol. VL - 55 IS - 3 N2 - We performed a case-control study of Parkinson's disease (PD) in a population characterized by a high prevalence of pesticide exposure and studied the joint effect of pesticide exposure and CYP2D6. Although they are based on a small group of subjects with the joint exposure, our findings are consistent with a gene-environment interaction disease model according to which (1) pesticides have a modest effect in subjects who are not CYP2D6 poor metabolizers, (2) pesticides' effect is increased in poor metabolizers (approximately twofold), and (3) poor metabolizers are not at increased PD risk in the absence of pesticide exposure. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/14991823/CYP2D6_polymorphism_pesticide_exposure_and_Parkinson's_disease_ L2 - https://doi.org/10.1002/ana.20051 DB - PRIME DP - Unbound Medicine ER -