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Alcohol and tobacco consumption as risk factors of dementia: a review of epidemiological studies.
Biomed Pharmacother. 2004 Mar; 58(2):95-9.BP

Abstract

The association between dementia and smoking or alcohol use has been examined in several epidemiological studies. In many case-control studies, a decreased risk of dementia or Alzheimer's disease (AD) was observed among smokers. However, when this association was analysed in prospective studies, an increased risk of AD was observed. In addition, in the PAQUID study, we showed that the decreased risk disappeared after adjustment for educational level and occupation. These factors are strong confounders in the association between dementia and tobacco use. We also showed that moderate consumption of wine was associated with a lower risk of developing AD. This result remains unchanged after adjustment for many potential confounders. The association between moderate alcohol consumption and risk of developing a dementia or AD was recently confirmed by prospective studies. In some studies, wine consumption was more specifically associated with a decreased risk, whereas beer or spirit consumption was not associated. These results suggest that tobacco consumption is not associated with a lower risk of dementia and that moderate alcohol intake does not increase the risk of developing dementia.

Authors+Show Affiliations

Letenneur L
Inserm U 593, case 11, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux cedex, France. Luc.Letenneur@bordeaux.inserm.fr
Larrieu S
No affiliation info available
Barberger-Gateau P
No affiliation info available

MeSH

Age FactorsAlcohol DrinkingAlzheimer DiseaseClinical Trials as TopicFemaleHumansMaleRisk FactorsSmokingWine

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

14992790

Citation

Letenneur, Luc, et al. "Alcohol and Tobacco Consumption as Risk Factors of Dementia: a Review of Epidemiological Studies." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 58, no. 2, 2004, pp. 95-9.
Letenneur L, Larrieu S, Barberger-Gateau P. Alcohol and tobacco consumption as risk factors of dementia: a review of epidemiological studies. Biomed Pharmacother. 2004;58(2):95-9.
Letenneur, L., Larrieu, S., & Barberger-Gateau, P. (2004). Alcohol and tobacco consumption as risk factors of dementia: a review of epidemiological studies. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 58(2), 95-9.
Letenneur L, Larrieu S, Barberger-Gateau P. Alcohol and Tobacco Consumption as Risk Factors of Dementia: a Review of Epidemiological Studies. Biomed Pharmacother. 2004;58(2):95-9. PubMed PMID: 14992790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol and tobacco consumption as risk factors of dementia: a review of epidemiological studies. AU - Letenneur,Luc, AU - Larrieu,Sophie, AU - Barberger-Gateau,Pascale, PY - 2003/11/18/received PY - 2004/3/3/pubmed PY - 2004/6/17/medline PY - 2004/3/3/entrez SP - 95 EP - 9 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 58 IS - 2 N2 - The association between dementia and smoking or alcohol use has been examined in several epidemiological studies. In many case-control studies, a decreased risk of dementia or Alzheimer's disease (AD) was observed among smokers. However, when this association was analysed in prospective studies, an increased risk of AD was observed. In addition, in the PAQUID study, we showed that the decreased risk disappeared after adjustment for educational level and occupation. These factors are strong confounders in the association between dementia and tobacco use. We also showed that moderate consumption of wine was associated with a lower risk of developing AD. This result remains unchanged after adjustment for many potential confounders. The association between moderate alcohol consumption and risk of developing a dementia or AD was recently confirmed by prospective studies. In some studies, wine consumption was more specifically associated with a decreased risk, whereas beer or spirit consumption was not associated. These results suggest that tobacco consumption is not associated with a lower risk of dementia and that moderate alcohol intake does not increase the risk of developing dementia. SN - 0753-3322 UR - https://www.unboundmedicine.com/medline/citation/14992790/Alcohol_and_tobacco_consumption_as_risk_factors_of_dementia:_a_review_of_epidemiological_studies_ DB - PRIME DP - Unbound Medicine ER -