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Clinical diagnosis and assessment of severity of confirmed dengue infections in Vietnamese children: is the world health organization classification system helpful?
Am J Trop Med Hyg. 2004 Feb; 70(2):172-9.AJ

Abstract

Classification of dengue using the current World Health Organization (WHO) system is not straightforward. In a large prospective study of pediatric dengue, no clinical or basic laboratory parameters clearly differentiated between children with and without dengue, although petechiae and hepatomegaly were independently associated with the diagnosis. Among the 712 dengue-infected children there was considerable overlap in the major clinical features. Mucosal bleeding was observed with equal frequency in those with dengue fever and dengue hemorrhagic fever (DHF), and petechiae, thrombocytopenia, and the tourniquet test differentiated poorly between the two diagnostic categories. Fifty-seven (18%) of 310 with shock did not fulfill all four criteria considered necessary for a diagnosis of DHF by the WHO, but use of the WHO provisional classification scheme resulted in considerable over-inflation of the DHF figures. If two separate entities truly exist rather than a continuous spectrum of disease, it is essential that some measure of capillary leak is included in any classification system, with less emphasis on bleeding and a specific platelet count.

Authors+Show Affiliations

Dong Nai Paediatric Centre, Dong Nai Province, Bien Hoa, Vietnam.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14993629

Citation

Phuong, Cao Xuan Thanh, et al. "Clinical Diagnosis and Assessment of Severity of Confirmed Dengue Infections in Vietnamese Children: Is the World Health Organization Classification System Helpful?" The American Journal of Tropical Medicine and Hygiene, vol. 70, no. 2, 2004, pp. 172-9.
Phuong CX, Nhan NT, Kneen R, et al. Clinical diagnosis and assessment of severity of confirmed dengue infections in Vietnamese children: is the world health organization classification system helpful? Am J Trop Med Hyg. 2004;70(2):172-9.
Phuong, C. X., Nhan, N. T., Kneen, R., Thuy, P. T., van Thien, C., Nga, N. T., Thuy, T. T., Solomon, T., Stepniewska, K., & Wills, B. (2004). Clinical diagnosis and assessment of severity of confirmed dengue infections in Vietnamese children: is the world health organization classification system helpful? The American Journal of Tropical Medicine and Hygiene, 70(2), 172-9.
Phuong CX, et al. Clinical Diagnosis and Assessment of Severity of Confirmed Dengue Infections in Vietnamese Children: Is the World Health Organization Classification System Helpful. Am J Trop Med Hyg. 2004;70(2):172-9. PubMed PMID: 14993629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical diagnosis and assessment of severity of confirmed dengue infections in Vietnamese children: is the world health organization classification system helpful? AU - Phuong,Cao Xuan Thanh, AU - Nhan,Ngo Thi, AU - Kneen,Rachel, AU - Thuy,Pham Thi Thu, AU - van Thien,Chu, AU - Nga,Nguyen Thi Thuy, AU - Thuy,Tran Thanh, AU - Solomon,Tom, AU - Stepniewska,Kasia, AU - Wills,Bridget, AU - ,, PY - 2004/3/3/pubmed PY - 2004/3/10/medline PY - 2004/3/3/entrez SP - 172 EP - 9 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 70 IS - 2 N2 - Classification of dengue using the current World Health Organization (WHO) system is not straightforward. In a large prospective study of pediatric dengue, no clinical or basic laboratory parameters clearly differentiated between children with and without dengue, although petechiae and hepatomegaly were independently associated with the diagnosis. Among the 712 dengue-infected children there was considerable overlap in the major clinical features. Mucosal bleeding was observed with equal frequency in those with dengue fever and dengue hemorrhagic fever (DHF), and petechiae, thrombocytopenia, and the tourniquet test differentiated poorly between the two diagnostic categories. Fifty-seven (18%) of 310 with shock did not fulfill all four criteria considered necessary for a diagnosis of DHF by the WHO, but use of the WHO provisional classification scheme resulted in considerable over-inflation of the DHF figures. If two separate entities truly exist rather than a continuous spectrum of disease, it is essential that some measure of capillary leak is included in any classification system, with less emphasis on bleeding and a specific platelet count. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/14993629/Clinical_diagnosis_and_assessment_of_severity_of_confirmed_dengue_infections_in_Vietnamese_children:_is_the_world_health_organization_classification_system_helpful L2 - https://medlineplus.gov/dengue.html DB - PRIME DP - Unbound Medicine ER -