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Parallel assessment of 24 monthly doses of rifampin, ofloxacin, and minocycline versus two years of World Health Organization multi-drug therapy for multi-bacillary leprosy.
Am J Trop Med Hyg. 2004 Feb; 70(2):197-200.AJ

Abstract

Monthly doses of rifampin, ofloxacin, and minocycline (ROM) are expected to be effective treatment for multi-bacillary leprosy. Patients with MB leprosy received ROM (n = 10) or World Health Organization multi-drug therapy (MDT) (n = 11). Treatment with ROM was given as 24 consecutive monthly observed doses of rifampin (600 mg), ofloxacin (400 mg), and minocycline (100 mg). Treatment with MDT was given as 24 consecutive monthly observed doses of rifampin (600 mg) and clofazimine (300 mg), and unobserved daily dapsone (100 mg) and clofazimine (50 mg). Twenty patients completed the 24-month regimens with > 99% compliance. Treatments with ROM and MDT were safe, tolerable, and caused similar improvements in lesions, bacterial indices, and histology. All MDT recipients developed clofazimine-induced pigmentation. Six ROM and nine MDT recipients assessed at five or more years after completion of treatment had no evidence of relapse. Twenty-four months of treatment with ROM is a safe, well-tolerated, and convenient regimen that may provide an alternate therapy to MDT for MB leprosy. Larger trials with sufficient follow-up would better define the role of ROM.

Authors+Show Affiliations

Leonard Wood Memorial Center for Leprosy Research, Cebu, The Philippines.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

14993633

Citation

Villahermosa, Laarni G., et al. "Parallel Assessment of 24 Monthly Doses of Rifampin, Ofloxacin, and Minocycline Versus Two Years of World Health Organization Multi-drug Therapy for Multi-bacillary Leprosy." The American Journal of Tropical Medicine and Hygiene, vol. 70, no. 2, 2004, pp. 197-200.
Villahermosa LG, Fajardo TT, Abalos RM, et al. Parallel assessment of 24 monthly doses of rifampin, ofloxacin, and minocycline versus two years of World Health Organization multi-drug therapy for multi-bacillary leprosy. Am J Trop Med Hyg. 2004;70(2):197-200.
Villahermosa, L. G., Fajardo, T. T., Abalos, R. M., Cellona, R. V., Balagon, M. V., Dela Cruz, E. C., Tan, E. V., Walsh, G. P., & Walsh, D. S. (2004). Parallel assessment of 24 monthly doses of rifampin, ofloxacin, and minocycline versus two years of World Health Organization multi-drug therapy for multi-bacillary leprosy. The American Journal of Tropical Medicine and Hygiene, 70(2), 197-200.
Villahermosa LG, et al. Parallel Assessment of 24 Monthly Doses of Rifampin, Ofloxacin, and Minocycline Versus Two Years of World Health Organization Multi-drug Therapy for Multi-bacillary Leprosy. Am J Trop Med Hyg. 2004;70(2):197-200. PubMed PMID: 14993633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parallel assessment of 24 monthly doses of rifampin, ofloxacin, and minocycline versus two years of World Health Organization multi-drug therapy for multi-bacillary leprosy. AU - Villahermosa,Laarni G, AU - Fajardo,Tranquilino T,Jr AU - Abalos,Rodolfo M, AU - Cellona,Roland V, AU - Balagon,Maria V, AU - Dela Cruz,Eduardo C, AU - Tan,Esterlina V, AU - Walsh,Gerald P, AU - Walsh,Douglas S, PY - 2004/3/3/pubmed PY - 2004/3/10/medline PY - 2004/3/3/entrez SP - 197 EP - 200 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 70 IS - 2 N2 - Monthly doses of rifampin, ofloxacin, and minocycline (ROM) are expected to be effective treatment for multi-bacillary leprosy. Patients with MB leprosy received ROM (n = 10) or World Health Organization multi-drug therapy (MDT) (n = 11). Treatment with ROM was given as 24 consecutive monthly observed doses of rifampin (600 mg), ofloxacin (400 mg), and minocycline (100 mg). Treatment with MDT was given as 24 consecutive monthly observed doses of rifampin (600 mg) and clofazimine (300 mg), and unobserved daily dapsone (100 mg) and clofazimine (50 mg). Twenty patients completed the 24-month regimens with > 99% compliance. Treatments with ROM and MDT were safe, tolerable, and caused similar improvements in lesions, bacterial indices, and histology. All MDT recipients developed clofazimine-induced pigmentation. Six ROM and nine MDT recipients assessed at five or more years after completion of treatment had no evidence of relapse. Twenty-four months of treatment with ROM is a safe, well-tolerated, and convenient regimen that may provide an alternate therapy to MDT for MB leprosy. Larger trials with sufficient follow-up would better define the role of ROM. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/14993633/Parallel_assessment_of_24_monthly_doses_of_rifampin_ofloxacin_and_minocycline_versus_two_years_of_World_Health_Organization_multi_drug_therapy_for_multi_bacillary_leprosy_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -