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Sensitivity and specificity for primary Sjögren's syndrome of IgA and IgG anti-alpha-fodrin antibodies detected by ELISA.
J Rheumatol. 2004 Mar; 31(3):504-7.JR

Abstract

OBJECTIVE

To investigate the sensitivity and specificity of anti-alpha-fodrin antibodies in patients with primary Sjögren's syndrome (pSS).

METHODS

IgA and IgG anti-alpha-fodrin antibodies were measured in the sera of 80 patients with pSS, 60 blood donors matched for age and sex, 50 patients with systemic lupus erythematosus (SLE), 30 with rheumatoid arthritis (RA), 20 with systemic sclerosis (SSc), and 10 with polymyositis or dermatomyositis (PM/DM) by an ELISA method employing recombinant human alpha-fodrin as antigen.

RESULTS

The sensitivity of IgA and IgG anti-alpha-fodrin antibodies for pSS was 32.50% and 21.25%, respectively. When the prevalence of these antibodies in patients with SLE, RA, SSc, and PM/DM was evaluated, we observed specificity of these antibodies of 68.18% and 79.09%, respectively. The sensitivity and specificity for pSS of the combined determination of IgA and IgG anti-alpha-fodrin antibodies were 40% and 58.18%, respectively.

CONCLUSION

The prevalences of IgA and IgG anti-alpha-fodrin antibodies in our patients with pSS and other chronic autoimmune diseases have induced us to doubt their use as diagnostic markers of pSS.

Authors+Show Affiliations

Department of Medical and Surgical Sciences, University of Padova, Padova, Italy. amelia.ruffatti@unipd.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14994395

Citation

Ruffatti, Amelia, et al. "Sensitivity and Specificity for Primary Sjögren's Syndrome of IgA and IgG Anti-alpha-fodrin Antibodies Detected By ELISA." The Journal of Rheumatology, vol. 31, no. 3, 2004, pp. 504-7.
Ruffatti A, Ostuni P, Grypiotis P, et al. Sensitivity and specificity for primary Sjögren's syndrome of IgA and IgG anti-alpha-fodrin antibodies detected by ELISA. J Rheumatol. 2004;31(3):504-7.
Ruffatti, A., Ostuni, P., Grypiotis, P., Botsios, C., Tonello, M., Grava, C., Favaro, M., & Todesco, S. (2004). Sensitivity and specificity for primary Sjögren's syndrome of IgA and IgG anti-alpha-fodrin antibodies detected by ELISA. The Journal of Rheumatology, 31(3), 504-7.
Ruffatti A, et al. Sensitivity and Specificity for Primary Sjögren's Syndrome of IgA and IgG Anti-alpha-fodrin Antibodies Detected By ELISA. J Rheumatol. 2004;31(3):504-7. PubMed PMID: 14994395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitivity and specificity for primary Sjögren's syndrome of IgA and IgG anti-alpha-fodrin antibodies detected by ELISA. AU - Ruffatti,Amelia, AU - Ostuni,Pierantonio, AU - Grypiotis,Panagiotis, AU - Botsios,Costantino, AU - Tonello,Marta, AU - Grava,Chiara, AU - Favaro,Maria, AU - Todesco,Silvano, PY - 2004/3/3/pubmed PY - 2004/6/25/medline PY - 2004/3/3/entrez SP - 504 EP - 7 JF - The Journal of rheumatology JO - J Rheumatol VL - 31 IS - 3 N2 - OBJECTIVE: To investigate the sensitivity and specificity of anti-alpha-fodrin antibodies in patients with primary Sjögren's syndrome (pSS). METHODS: IgA and IgG anti-alpha-fodrin antibodies were measured in the sera of 80 patients with pSS, 60 blood donors matched for age and sex, 50 patients with systemic lupus erythematosus (SLE), 30 with rheumatoid arthritis (RA), 20 with systemic sclerosis (SSc), and 10 with polymyositis or dermatomyositis (PM/DM) by an ELISA method employing recombinant human alpha-fodrin as antigen. RESULTS: The sensitivity of IgA and IgG anti-alpha-fodrin antibodies for pSS was 32.50% and 21.25%, respectively. When the prevalence of these antibodies in patients with SLE, RA, SSc, and PM/DM was evaluated, we observed specificity of these antibodies of 68.18% and 79.09%, respectively. The sensitivity and specificity for pSS of the combined determination of IgA and IgG anti-alpha-fodrin antibodies were 40% and 58.18%, respectively. CONCLUSION: The prevalences of IgA and IgG anti-alpha-fodrin antibodies in our patients with pSS and other chronic autoimmune diseases have induced us to doubt their use as diagnostic markers of pSS. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/14994395/Sensitivity_and_specificity_for_primary_Sjögren's_syndrome_of_IgA_and_IgG_anti_alpha_fodrin_antibodies_detected_by_ELISA_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&pmid=14994395 DB - PRIME DP - Unbound Medicine ER -