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Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects.

Abstract

To determine the effects of chromium (Cr) supplementations on oxidative stress of type 2 diabetes and euglycemic (EU) subjects, adult having HbA(1C) values of <6.0% (EU), 6.8-8.5% (mildly hyperglycemic, MH), and >8.5% (severely hyperglycemic, SH) were supplemented for 6 months with 1000 microg/day of Cr (as Cr yeast) or with a placebo. In the beginning, the levels of the plasma Cr in the MH and SH groups were 25-30% lower than those of the EU subjects. The values of thiobarbituric acid reactive substances (TBARS) and total antioxidative status (TAS) of the MH and SH groups were significantly higher than those of the EU ones. Following supplementations, the levels of plasma TBARS in the Cr groups of MH and SH groups were significantly decreased (the inverse was found in the EU) and showed no significant changes in the placebo group. The levels of plasma TAS in the Cr groups of EU and MH were significantly decreased (the inverse was found in the SH) and showed no significant changes in the placebo group. No significant difference was found in the antioxidant enzyme (superoxide dismutase, glutathione peroxidase, catalase) activities during supplementations. These data suggest that Cr supplementation was an effective treatment strategy to minimize increased oxidative stress in type 2 diabetes mellitus patients whose HbA(1C) level was >8.5%, and the Cr in EU groups might act as a prooxidant.

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  • Authors+Show Affiliations

    ,

    School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan. chenghh@tmu.edu.tw

    , ,

    Source

    MeSH

    Antioxidants
    Catalase
    Chromium
    Diabetes Mellitus, Type 2
    Dietary Supplements
    Double-Blind Method
    Female
    Glycated Hemoglobin A
    Humans
    Male
    Middle Aged
    Oxidative Stress
    Placebos
    Thiobarbituric Acid Reactive Substances

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14995150

    Citation

    Cheng, Hsing-Hsien, et al. "Antioxidant Effects of Chromium Supplementation With Type 2 Diabetes Mellitus and Euglycemic Subjects." Journal of Agricultural and Food Chemistry, vol. 52, no. 5, 2004, pp. 1385-9.
    Cheng HH, Lai MH, Hou WC, et al. Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects. J Agric Food Chem. 2004;52(5):1385-9.
    Cheng, H. H., Lai, M. H., Hou, W. C., & Huang, C. L. (2004). Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects. Journal of Agricultural and Food Chemistry, 52(5), pp. 1385-9.
    Cheng HH, et al. Antioxidant Effects of Chromium Supplementation With Type 2 Diabetes Mellitus and Euglycemic Subjects. J Agric Food Chem. 2004 Mar 10;52(5):1385-9. PubMed PMID: 14995150.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects. AU - Cheng,Hsing-Hsien, AU - Lai,Ming-Hoang, AU - Hou,Wen-Chi, AU - Huang,Chen-Ling, PY - 2004/3/5/pubmed PY - 2004/5/5/medline PY - 2004/3/5/entrez SP - 1385 EP - 9 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 52 IS - 5 N2 - To determine the effects of chromium (Cr) supplementations on oxidative stress of type 2 diabetes and euglycemic (EU) subjects, adult having HbA(1C) values of <6.0% (EU), 6.8-8.5% (mildly hyperglycemic, MH), and >8.5% (severely hyperglycemic, SH) were supplemented for 6 months with 1000 microg/day of Cr (as Cr yeast) or with a placebo. In the beginning, the levels of the plasma Cr in the MH and SH groups were 25-30% lower than those of the EU subjects. The values of thiobarbituric acid reactive substances (TBARS) and total antioxidative status (TAS) of the MH and SH groups were significantly higher than those of the EU ones. Following supplementations, the levels of plasma TBARS in the Cr groups of MH and SH groups were significantly decreased (the inverse was found in the EU) and showed no significant changes in the placebo group. The levels of plasma TAS in the Cr groups of EU and MH were significantly decreased (the inverse was found in the SH) and showed no significant changes in the placebo group. No significant difference was found in the antioxidant enzyme (superoxide dismutase, glutathione peroxidase, catalase) activities during supplementations. These data suggest that Cr supplementation was an effective treatment strategy to minimize increased oxidative stress in type 2 diabetes mellitus patients whose HbA(1C) level was >8.5%, and the Cr in EU groups might act as a prooxidant. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/14995150/full_citation L2 - https://dx.doi.org/10.1021/jf035074j DB - PRIME DP - Unbound Medicine ER -