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Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha.
Int Immunopharmacol. 2004 Feb; 4(2):279-87.II

Abstract

Paeonol, a major phenolic component of Moutan Cortex, was known to have antiaggregatory, antioxidant and antiinflammatory activities. In the present study, we tried to elucidate the effects of paeonol on anaphylactic reaction and its mode of action. Paeonol significantly inhibited histamine release from the rat peritoneal mast cells (RPMCs) treated with compound 48/80, a mast cell degranulator. The release of tumor necrosis factor (TNF)-alpha mast cell activating cytokine was significantly suppressed in RBL-2H3 mast cells pretreated with anti-dinitrophenyl (DNP) immunoglobulin E (IgE) in a dose-dependent manner. Paeonol significantly inhibited IgE production in B cells activated by anti-CD40 mAb, recombinant interleukin-4 (rIL-4) and recombinant histamine releasing factor (rHRF). Paeonol effectively downregulated the expression of IL-4 in the activated B cells by reverse transcription-polymerase chain reaction (RT-PCR). We also confirmed that paeonol effectively inhibited anaphylactic shock in mice by 90% at a dose of 0.5 mg/mouse versus PBS treated control 2 h after the i.p. injection of compound 48/80. These results suggest that paeonol has antianaphylatic activity by regulating histamine and TNF-alpha.

Authors+Show Affiliations

Department of Oncology, Graduate School of East-West Medical Science, KyungHee University, 1 Seochunri Kiheungeup, Yoingin 449-701, South Korea. sungkim7@khu.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14996419

Citation

Kim, Sung Hoon, et al. "Paeonol Inhibits Anaphylactic Reaction By Regulating Histamine and TNF-alpha." International Immunopharmacology, vol. 4, no. 2, 2004, pp. 279-87.
Kim SH, Kim SA, Park MK, et al. Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha. Int Immunopharmacol. 2004;4(2):279-87.
Kim, S. H., Kim, S. A., Park, M. K., Kim, S. H., Park, Y. D., Na, H. J., Kim, H. M., Shin, M. K., & Ahn, K. S. (2004). Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha. International Immunopharmacology, 4(2), 279-87.
Kim SH, et al. Paeonol Inhibits Anaphylactic Reaction By Regulating Histamine and TNF-alpha. Int Immunopharmacol. 2004;4(2):279-87. PubMed PMID: 14996419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha. AU - Kim,Sung Hoon, AU - Kim,Seung-Ae, AU - Park,Mi-Kyung, AU - Kim,Seung-Hyung, AU - Park,Young-Doo, AU - Na,Ho-Jeong, AU - Kim,Hyung-Min, AU - Shin,Min-Kyu, AU - Ahn,Kyoo-Seok, PY - 2003/10/17/received PY - 2003/11/04/revised PY - 2003/12/19/accepted PY - 2004/3/5/pubmed PY - 2004/12/16/medline PY - 2004/3/5/entrez SP - 279 EP - 87 JF - International immunopharmacology JO - Int Immunopharmacol VL - 4 IS - 2 N2 - Paeonol, a major phenolic component of Moutan Cortex, was known to have antiaggregatory, antioxidant and antiinflammatory activities. In the present study, we tried to elucidate the effects of paeonol on anaphylactic reaction and its mode of action. Paeonol significantly inhibited histamine release from the rat peritoneal mast cells (RPMCs) treated with compound 48/80, a mast cell degranulator. The release of tumor necrosis factor (TNF)-alpha mast cell activating cytokine was significantly suppressed in RBL-2H3 mast cells pretreated with anti-dinitrophenyl (DNP) immunoglobulin E (IgE) in a dose-dependent manner. Paeonol significantly inhibited IgE production in B cells activated by anti-CD40 mAb, recombinant interleukin-4 (rIL-4) and recombinant histamine releasing factor (rHRF). Paeonol effectively downregulated the expression of IL-4 in the activated B cells by reverse transcription-polymerase chain reaction (RT-PCR). We also confirmed that paeonol effectively inhibited anaphylactic shock in mice by 90% at a dose of 0.5 mg/mouse versus PBS treated control 2 h after the i.p. injection of compound 48/80. These results suggest that paeonol has antianaphylatic activity by regulating histamine and TNF-alpha. SN - 1567-5769 UR - https://www.unboundmedicine.com/medline/citation/14996419/Paeonol_inhibits_anaphylactic_reaction_by_regulating_histamine_and_TNF_alpha_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(03)00300-X DB - PRIME DP - Unbound Medicine ER -