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Associations among oxidized low-density lipoprotein antibody, C-reactive protein, interleukin-6, and circulating cell adhesion molecules in patients with unstable angina pectoris.
Am J Cardiol. 2004 Mar 01; 93(5):554-8.AJ

Abstract

Oxidized low-density lipoprotein (LDL) is believed to play a key role in the development of atherosclerosis. However, the significance of anti-oxidized LDL antibody in atherogenesis is unclear. The purposes of this study were to assess whether anti-oxidized LDL antibody titers are related to other inflammatory markers of possible interest in atherosclerotic development, such as soluble cell adhesion molecules, interleukin-6, and C-reactive protein (CRP), and to determine the prognostic value of anti-oxidized LDL antibody as a predictor of cardiac events in patients with unstable angina pectoris. Sixty patients (35 men and 25 women; mean age 60 years) with unstable angina were included in this study. The levels of CRP and of intercellular adhesion molecule-1 (ICAM-1) at 24 and 72 hours after admission were significantly higher than their baseline levels (p <0.05, respectively). After adjusting for age, gender, body mass index, and statin use, anti-oxidized LDL antibodies were positively correlated with CRP (r = 0.72, p <0.001) and ICAM-1 (r = 0.68, p <0.001). Elevated anti-oxidized LDL antibodies (mean >11.37 U/ml) and CRP levels (median >2.4 mg/L) on admission were correlated with a significantly lower 16-month, event-free survival rate (Kaplan-Meier event-free survival analysis, log-rank p <0.01 and p <0.05, respectively). Multivariate analysis by logistic regression revealed that elevated levels of anti-oxidized LDL antibody (mean >11.3 U/ml) on admission were an independent risk factor for an adverse cardiac event (odds ratio 2.2, 95% confidence interval 1.5 to 10.7, p = 0.001). This study demonstrates that anti-oxidized LDL antibody expression is associated with the expression of CRP and adhesion molecules, especially ICAM-1, and is a predictor of cardiac events in patients with unstable angina pectoris. The observed elevated levels of anti-oxidized LDL antibody suggest plaque instability and may be useful for identifying patients at higher risk of a cardiac event.

Authors+Show Affiliations

Division of Cardiology, Department of Internal Medicine, Kang-Dong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14996578

Citation

Doo, Young-Cheoul, et al. "Associations Among Oxidized Low-density Lipoprotein Antibody, C-reactive Protein, Interleukin-6, and Circulating Cell Adhesion Molecules in Patients With Unstable Angina Pectoris." The American Journal of Cardiology, vol. 93, no. 5, 2004, pp. 554-8.
Doo YC, Han SJ, Lee JH, et al. Associations among oxidized low-density lipoprotein antibody, C-reactive protein, interleukin-6, and circulating cell adhesion molecules in patients with unstable angina pectoris. Am J Cardiol. 2004;93(5):554-8.
Doo, Y. C., Han, S. J., Lee, J. H., Cho, G. Y., Hong, K. S., Han, K. R., Lee, N. H., Oh, D. J., Ryu, K. H., Rhim, C. Y., Lee, K. H., & Lee, Y. (2004). Associations among oxidized low-density lipoprotein antibody, C-reactive protein, interleukin-6, and circulating cell adhesion molecules in patients with unstable angina pectoris. The American Journal of Cardiology, 93(5), 554-8.
Doo YC, et al. Associations Among Oxidized Low-density Lipoprotein Antibody, C-reactive Protein, Interleukin-6, and Circulating Cell Adhesion Molecules in Patients With Unstable Angina Pectoris. Am J Cardiol. 2004 Mar 1;93(5):554-8. PubMed PMID: 14996578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations among oxidized low-density lipoprotein antibody, C-reactive protein, interleukin-6, and circulating cell adhesion molecules in patients with unstable angina pectoris. AU - Doo,Young-Cheoul, AU - Han,Sang-Jin, AU - Lee,Jun-Hee, AU - Cho,Goo-Yung, AU - Hong,Kyung-Soon, AU - Han,Kyoo-Rok, AU - Lee,Nam-Ho, AU - Oh,Dong-Jin, AU - Ryu,Kyu-Hyung, AU - Rhim,Chong-Yun, AU - Lee,Kwang-Hwahk, AU - Lee,Yung, PY - 2003/09/21/received PY - 2003/11/04/revised PY - 2003/11/04/accepted PY - 2004/3/5/pubmed PY - 2004/4/14/medline PY - 2004/3/5/entrez SP - 554 EP - 8 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 93 IS - 5 N2 - Oxidized low-density lipoprotein (LDL) is believed to play a key role in the development of atherosclerosis. However, the significance of anti-oxidized LDL antibody in atherogenesis is unclear. The purposes of this study were to assess whether anti-oxidized LDL antibody titers are related to other inflammatory markers of possible interest in atherosclerotic development, such as soluble cell adhesion molecules, interleukin-6, and C-reactive protein (CRP), and to determine the prognostic value of anti-oxidized LDL antibody as a predictor of cardiac events in patients with unstable angina pectoris. Sixty patients (35 men and 25 women; mean age 60 years) with unstable angina were included in this study. The levels of CRP and of intercellular adhesion molecule-1 (ICAM-1) at 24 and 72 hours after admission were significantly higher than their baseline levels (p <0.05, respectively). After adjusting for age, gender, body mass index, and statin use, anti-oxidized LDL antibodies were positively correlated with CRP (r = 0.72, p <0.001) and ICAM-1 (r = 0.68, p <0.001). Elevated anti-oxidized LDL antibodies (mean >11.37 U/ml) and CRP levels (median >2.4 mg/L) on admission were correlated with a significantly lower 16-month, event-free survival rate (Kaplan-Meier event-free survival analysis, log-rank p <0.01 and p <0.05, respectively). Multivariate analysis by logistic regression revealed that elevated levels of anti-oxidized LDL antibody (mean >11.3 U/ml) on admission were an independent risk factor for an adverse cardiac event (odds ratio 2.2, 95% confidence interval 1.5 to 10.7, p = 0.001). This study demonstrates that anti-oxidized LDL antibody expression is associated with the expression of CRP and adhesion molecules, especially ICAM-1, and is a predictor of cardiac events in patients with unstable angina pectoris. The observed elevated levels of anti-oxidized LDL antibody suggest plaque instability and may be useful for identifying patients at higher risk of a cardiac event. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/14996578/Associations_among_oxidized_low_density_lipoprotein_antibody_C_reactive_protein_interleukin_6_and_circulating_cell_adhesion_molecules_in_patients_with_unstable_angina_pectoris_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002914903016461 DB - PRIME DP - Unbound Medicine ER -