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Serum zinc, selenium, copper, and lead levels in women with second-trimester induced abortion resulting from neural tube defects: a preliminary study.
Biol Trace Elem Res. 2004 Mar; 97(3):225-35.BT

Abstract

Neural tube defects are important causes of infant mortality and childhood morbidity. We investigated the relationship between zinc, selenium, copper, and lead concentrations and neural-tube-defect occurrence in women with a second-trimester termination due to fetal-neural-tube defects (NTDs) in this case-control study. Fourteen pregnant women whose pregnancies were terminated as a result of second-trimester ultrasonographic diagnosis of neural tube defects were recruited as cases. The control group (n = 14) consisted of women who were selected among age-, gravidity-, and socio-economic-state (SES)-matched women who had a normal triple-screen and targeted ultrasound during the second trimester with documented normal fetal outcome. Zinc and copper determinations were made using flame atomic absorption spectrophotometer (AAS). Graphite furnace AAS was used for Pb, and Se levels were measured with hydride generation AAS. Cases had significantly low serum zinc and selenium levels (62.48+/-15.9 vs 102.6+/-23.7 and 55.16+/-11.3 vs 77.4+/-5.5, respectively, p<0.001). Serum Cu and whole-blood Pb levels were significantly high when compared to controls. There was a negative correlation between serum zinc and selenium levels, and serum copper levels (r=-425 and -0.443, p<0.05). Our results are consistent with some previous reports. The etiology of NTDs cannot be explained with one strict etiologic mechanism. On the contrary, an interaction among environmental, genetic, and nutritional factors such as trace elements and vitamins would explain these anomalies. If folic acid supplementation is given, additional Zn supplementation should be considered for the further decrease in the recurrence and occurrence of NTDs.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14997023

Citation

Cengiz, Bora, et al. "Serum Zinc, Selenium, Copper, and Lead Levels in Women With Second-trimester Induced Abortion Resulting From Neural Tube Defects: a Preliminary Study." Biological Trace Element Research, vol. 97, no. 3, 2004, pp. 225-35.
Cengiz B, Söylemez F, Oztürk E, et al. Serum zinc, selenium, copper, and lead levels in women with second-trimester induced abortion resulting from neural tube defects: a preliminary study. Biol Trace Elem Res. 2004;97(3):225-35.
Cengiz, B., Söylemez, F., Oztürk, E., & Cavdar, A. O. (2004). Serum zinc, selenium, copper, and lead levels in women with second-trimester induced abortion resulting from neural tube defects: a preliminary study. Biological Trace Element Research, 97(3), 225-35.
Cengiz B, et al. Serum Zinc, Selenium, Copper, and Lead Levels in Women With Second-trimester Induced Abortion Resulting From Neural Tube Defects: a Preliminary Study. Biol Trace Elem Res. 2004;97(3):225-35. PubMed PMID: 14997023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum zinc, selenium, copper, and lead levels in women with second-trimester induced abortion resulting from neural tube defects: a preliminary study. AU - Cengiz,Bora, AU - Söylemez,Feride, AU - Oztürk,Ebru, AU - Cavdar,Ayhan O, PY - 2003/06/26/received PY - 2003/09/01/accepted PY - 2004/3/5/pubmed PY - 2004/11/17/medline PY - 2004/3/5/entrez SP - 225 EP - 35 JF - Biological trace element research JO - Biol Trace Elem Res VL - 97 IS - 3 N2 - Neural tube defects are important causes of infant mortality and childhood morbidity. We investigated the relationship between zinc, selenium, copper, and lead concentrations and neural-tube-defect occurrence in women with a second-trimester termination due to fetal-neural-tube defects (NTDs) in this case-control study. Fourteen pregnant women whose pregnancies were terminated as a result of second-trimester ultrasonographic diagnosis of neural tube defects were recruited as cases. The control group (n = 14) consisted of women who were selected among age-, gravidity-, and socio-economic-state (SES)-matched women who had a normal triple-screen and targeted ultrasound during the second trimester with documented normal fetal outcome. Zinc and copper determinations were made using flame atomic absorption spectrophotometer (AAS). Graphite furnace AAS was used for Pb, and Se levels were measured with hydride generation AAS. Cases had significantly low serum zinc and selenium levels (62.48+/-15.9 vs 102.6+/-23.7 and 55.16+/-11.3 vs 77.4+/-5.5, respectively, p<0.001). Serum Cu and whole-blood Pb levels were significantly high when compared to controls. There was a negative correlation between serum zinc and selenium levels, and serum copper levels (r=-425 and -0.443, p<0.05). Our results are consistent with some previous reports. The etiology of NTDs cannot be explained with one strict etiologic mechanism. On the contrary, an interaction among environmental, genetic, and nutritional factors such as trace elements and vitamins would explain these anomalies. If folic acid supplementation is given, additional Zn supplementation should be considered for the further decrease in the recurrence and occurrence of NTDs. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/14997023/Serum_zinc_selenium_copper_and_lead_levels_in_women_with_second_trimester_induced_abortion_resulting_from_neural_tube_defects:_a_preliminary_study_ L2 - https://dx.doi.org/10.1385/BTER:97:3:225 DB - PRIME DP - Unbound Medicine ER -