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Peri-intubation cardiovascular response during low dose remifentanil or sufentanil administration in association with propofol TCI. A double blind comparison.
Minerva Anestesiol. 2004 Mar; 70(3):109-15.MA

Abstract

AIM

The aim of this study was to compare the effects on cardiovascular modifications induced by tracheal intubation when low dose infusion of remifentanil or sufentanil are used in association with propofol target controlled infusion.

METHODS

Sixty normotensive, ASA I-II-III, Mallampati Score <3 undergoing general anaesthesia for major elective abdominal surgery, received i.m. midazolam (0.05 mg/kg) and atropine (0.01 mg/kg) 30 min before induction. They were randomly divided in a double-blind fashion into two groups receiving for induction respectively target controlled infusion of propofol (site-effect 3.0 microg/ml) and sufentanil (0.01 microg/kg/min) or remifentanil (0.1 microg/kg/ min) infusion. Rocuronium (0.6 mg/kg) was administered. Following intubation, the lungs were mechanically ventilated with an oxygen/air mixture.

RESULTS

Bispectral index score and haemodynamic variables were recorded at baseline, after induction, during intubation and 1-3-5 min after the trachea was intubated. No differences in systolic and diastolic arterial pressure were observed in the sufentanil group, while the remifentanil group showed transient systolic and diastolic variations after intubating manoeuvers. The heart rate and bispectral index score were not affected in either group.

CONCLUSION

In healthy normotensive patients the use of a small dose of either remifentanil or sufentanil after standard midazolam premedication, proved to be an effective strategy to blunt the cardiovascular response to intubation.

Authors+Show Affiliations

Department of Anaesthesiological, Surgical and Emergency Sciences, Second University of Naples, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

14997083

Citation

Iannuzzi, E, et al. "Peri-intubation Cardiovascular Response During Low Dose Remifentanil or Sufentanil Administration in Association With Propofol TCI. a Double Blind Comparison." Minerva Anestesiologica, vol. 70, no. 3, 2004, pp. 109-15.
Iannuzzi E, Iannuzzi M, Cirillo V, et al. Peri-intubation cardiovascular response during low dose remifentanil or sufentanil administration in association with propofol TCI. A double blind comparison. Minerva Anestesiol. 2004;70(3):109-15.
Iannuzzi, E., Iannuzzi, M., Cirillo, V., Viola, G., Parisi, R., Cerulli, A., & Chiefari, M. (2004). Peri-intubation cardiovascular response during low dose remifentanil or sufentanil administration in association with propofol TCI. A double blind comparison. Minerva Anestesiologica, 70(3), 109-15.
Iannuzzi E, et al. Peri-intubation Cardiovascular Response During Low Dose Remifentanil or Sufentanil Administration in Association With Propofol TCI. a Double Blind Comparison. Minerva Anestesiol. 2004;70(3):109-15. PubMed PMID: 14997083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peri-intubation cardiovascular response during low dose remifentanil or sufentanil administration in association with propofol TCI. A double blind comparison. AU - Iannuzzi,E, AU - Iannuzzi,M, AU - Cirillo,V, AU - Viola,G, AU - Parisi,R, AU - Cerulli,A, AU - Chiefari,M, PY - 2004/3/5/pubmed PY - 2005/1/4/medline PY - 2004/3/5/entrez SP - 109 EP - 15 JF - Minerva anestesiologica JO - Minerva Anestesiol VL - 70 IS - 3 N2 - AIM: The aim of this study was to compare the effects on cardiovascular modifications induced by tracheal intubation when low dose infusion of remifentanil or sufentanil are used in association with propofol target controlled infusion. METHODS: Sixty normotensive, ASA I-II-III, Mallampati Score <3 undergoing general anaesthesia for major elective abdominal surgery, received i.m. midazolam (0.05 mg/kg) and atropine (0.01 mg/kg) 30 min before induction. They were randomly divided in a double-blind fashion into two groups receiving for induction respectively target controlled infusion of propofol (site-effect 3.0 microg/ml) and sufentanil (0.01 microg/kg/min) or remifentanil (0.1 microg/kg/ min) infusion. Rocuronium (0.6 mg/kg) was administered. Following intubation, the lungs were mechanically ventilated with an oxygen/air mixture. RESULTS: Bispectral index score and haemodynamic variables were recorded at baseline, after induction, during intubation and 1-3-5 min after the trachea was intubated. No differences in systolic and diastolic arterial pressure were observed in the sufentanil group, while the remifentanil group showed transient systolic and diastolic variations after intubating manoeuvers. The heart rate and bispectral index score were not affected in either group. CONCLUSION: In healthy normotensive patients the use of a small dose of either remifentanil or sufentanil after standard midazolam premedication, proved to be an effective strategy to blunt the cardiovascular response to intubation. SN - 0375-9393 UR - https://www.unboundmedicine.com/medline/citation/14997083/Peri_intubation_cardiovascular_response_during_low_dose_remifentanil_or_sufentanil_administration_in_association_with_propofol_TCI__A_double_blind_comparison_ L2 - http://www.minervamedica.it/index2.t?show=R02Y2004N03A0109 DB - PRIME DP - Unbound Medicine ER -