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Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids.
Br J Cancer. 2004 Mar 08; 90(5):996-1002.BJ

Abstract

The aim of the study was to assess the total energy expenditure (TEE), resting energy expenditure (REE) and physical activity level (PAL) in home-living cachectic patients with advanced pancreatic cancer. The influence of an energy and protein dense oral supplement either enriched with or without the n-3 fatty acid eicosapentaenoic acid (EPA) and administered over an 8-week period was also determined. In total, 24 patients were studied at baseline. The total energy expenditure was measured using doubly labelled water and REE determined by indirect calorimetry. Patients were studied at baseline and then randomised to either oral nutritional supplement. Measurements were repeated at 8 weeks. At baseline, REE was increased compared with predicted values for healthy individuals (1387(42) vs 1268(32) kcal day(-1), P=0.001), but TEE (1732(82) vs 1903(48) kcal day(-1), P=0.023) and PAL (1.24(0.04) vs 1.50) were reduced. After 8 weeks, the REE, TEE and PAL of patients who received the control supplement did not change significantly. In contrast, although REE did not change, TEE and PAL increased significantly in those who received the n-3 (EPA) enriched supplement. In summary, patients with advanced pancreatic cancer were hypermetabolic. However, TEE was reduced and this was secondary to a reduction in physical activity. The control energy and protein dense oral supplement did not influence the physical activity component of TEE. In contrast, administration of the supplement enriched with EPA was associated with an increase in physical activity, which may reflect improved quality of life.

Authors+Show Affiliations

1Department of Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary, Little France Crescent, Edinburgh EH16 4SA, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

14997196

Citation

Moses, A W G., et al. "Reduced Total Energy Expenditure and Physical Activity in Cachectic Patients With Pancreatic Cancer Can Be Modulated By an Energy and Protein Dense Oral Supplement Enriched With N-3 Fatty Acids." British Journal of Cancer, vol. 90, no. 5, 2004, pp. 996-1002.
Moses AW, Slater C, Preston T, et al. Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids. Br J Cancer. 2004;90(5):996-1002.
Moses, A. W., Slater, C., Preston, T., Barber, M. D., & Fearon, K. C. (2004). Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids. British Journal of Cancer, 90(5), 996-1002.
Moses AW, et al. Reduced Total Energy Expenditure and Physical Activity in Cachectic Patients With Pancreatic Cancer Can Be Modulated By an Energy and Protein Dense Oral Supplement Enriched With N-3 Fatty Acids. Br J Cancer. 2004 Mar 8;90(5):996-1002. PubMed PMID: 14997196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids. AU - Moses,A W G, AU - Slater,C, AU - Preston,T, AU - Barber,M D, AU - Fearon,K C H, PY - 2004/3/5/pubmed PY - 2004/4/30/medline PY - 2004/3/5/entrez SP - 996 EP - 1002 JF - British journal of cancer JO - Br J Cancer VL - 90 IS - 5 N2 - The aim of the study was to assess the total energy expenditure (TEE), resting energy expenditure (REE) and physical activity level (PAL) in home-living cachectic patients with advanced pancreatic cancer. The influence of an energy and protein dense oral supplement either enriched with or without the n-3 fatty acid eicosapentaenoic acid (EPA) and administered over an 8-week period was also determined. In total, 24 patients were studied at baseline. The total energy expenditure was measured using doubly labelled water and REE determined by indirect calorimetry. Patients were studied at baseline and then randomised to either oral nutritional supplement. Measurements were repeated at 8 weeks. At baseline, REE was increased compared with predicted values for healthy individuals (1387(42) vs 1268(32) kcal day(-1), P=0.001), but TEE (1732(82) vs 1903(48) kcal day(-1), P=0.023) and PAL (1.24(0.04) vs 1.50) were reduced. After 8 weeks, the REE, TEE and PAL of patients who received the control supplement did not change significantly. In contrast, although REE did not change, TEE and PAL increased significantly in those who received the n-3 (EPA) enriched supplement. In summary, patients with advanced pancreatic cancer were hypermetabolic. However, TEE was reduced and this was secondary to a reduction in physical activity. The control energy and protein dense oral supplement did not influence the physical activity component of TEE. In contrast, administration of the supplement enriched with EPA was associated with an increase in physical activity, which may reflect improved quality of life. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/14997196/Reduced_total_energy_expenditure_and_physical_activity_in_cachectic_patients_with_pancreatic_cancer_can_be_modulated_by_an_energy_and_protein_dense_oral_supplement_enriched_with_n_3_fatty_acids_ L2 - https://doi.org/10.1038/sj.bjc.6601620 DB - PRIME DP - Unbound Medicine ER -