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Serum androgen levels in healthy premenopausal women with and without sexual dysfunction: Part A. Serum androgen levels in women aged 20-49 years with no complaints of sexual dysfunction.
Int J Impot Res. 2004 Apr; 16(2):112-20.IJ

Abstract

Androgen insufficiency is a recognized cause of sexual dysfunction in men and women. Age-related decrements in adrenal and gonadal androgen levels also occur naturally in both sexes. At present, it is unclear if a woman's low serum androgen level is a reflection of the expected normal age-related decline or indicative of an underlying androgen-deficient state. We studied premenopausal women with no complaints of sexual dysfunction to help define a normal female androgen profile. In all, 60 healthy, normally menstruating women, ages 20-49 y, were studied. The Abbreviated Sexual Function Questionnaire was administered along with a detailed interview. Radioimmunoassay measurements of morning serum testosterone (T), free testosterone (fT), dehydroepiandrosterone-sulfate (DHEAS), sex hormone-binding globulin (SHBG), and free androgen index (FAI) were measured during days 8-15 of the menstrual cycle. In women 20-49 y old without complaints of sexual dysfunction, serum androgen levels exhibit a progressive stepwise decline. Comparing values obtained in women age 20-29 y to those obtained in women 40-49 y, specific hormone decrements were DHEAS 195.6-140.4 microg/dl, serum T 51.5-33.7 ng/dl, fT 1.51-1.03 pg/ml. SHBG did not change significantly in women in this age group. The FAI reflected the age-related decrease in female androgen levels. The framework for the development of a female androgen profile in women with no complaints of sexual dysfunction has been established, and an age-related decrease in testosterone and its adrenal precursor, DHEAS, has been demonstrated. The FAI mirrors these decreases and its usefulness in clinical practice is confirmed. A precipitous decline in all androgens occurs after the decade of the 20s, yet SHBG does not show a significant change throughout the premenopausal years.

Authors+Show Affiliations

Guay A
Center for Sexual Function, Lahey Clinic Northshore, One Essex Center Drive, Peabody, MA 01960, USA. andre.t.guay@lahey.org
Munarriz R
No affiliation info available
Jacobson J
No affiliation info available
Talakoub L
No affiliation info available
Traish A
No affiliation info available
Quirk F
No affiliation info available
Goldstein I
No affiliation info available
Spark R
No affiliation info available

MeSH

AdultAge FactorsAndrogensCase-Control StudiesDehydroepiandrosterone SulfateFemaleHumansMiddle AgedPremenopauseReference ValuesReproducibility of ResultsSex Hormone-Binding GlobulinSexual Dysfunctions, PsychologicalSurveys and QuestionnairesTestosterone

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14999217

Citation

Guay, A, et al. "Serum Androgen Levels in Healthy Premenopausal Women With and Without Sexual Dysfunction: Part A. Serum Androgen Levels in Women Aged 20-49 Years With No Complaints of Sexual Dysfunction." International Journal of Impotence Research, vol. 16, no. 2, 2004, pp. 112-20.
Guay A, Munarriz R, Jacobson J, et al. Serum androgen levels in healthy premenopausal women with and without sexual dysfunction: Part A. Serum androgen levels in women aged 20-49 years with no complaints of sexual dysfunction. Int J Impot Res. 2004;16(2):112-20.
Guay, A., Munarriz, R., Jacobson, J., Talakoub, L., Traish, A., Quirk, F., Goldstein, I., & Spark, R. (2004). Serum androgen levels in healthy premenopausal women with and without sexual dysfunction: Part A. Serum androgen levels in women aged 20-49 years with no complaints of sexual dysfunction. International Journal of Impotence Research, 16(2), 112-20.
Guay A, et al. Serum Androgen Levels in Healthy Premenopausal Women With and Without Sexual Dysfunction: Part A. Serum Androgen Levels in Women Aged 20-49 Years With No Complaints of Sexual Dysfunction. Int J Impot Res. 2004;16(2):112-20. PubMed PMID: 14999217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum androgen levels in healthy premenopausal women with and without sexual dysfunction: Part A. Serum androgen levels in women aged 20-49 years with no complaints of sexual dysfunction. AU - Guay,A, AU - Munarriz,R, AU - Jacobson,J, AU - Talakoub,L, AU - Traish,A, AU - Quirk,F, AU - Goldstein,I, AU - Spark,R, PY - 2004/3/5/pubmed PY - 2004/12/23/medline PY - 2004/3/5/entrez SP - 112 EP - 20 JF - International journal of impotence research JO - Int J Impot Res VL - 16 IS - 2 N2 - Androgen insufficiency is a recognized cause of sexual dysfunction in men and women. Age-related decrements in adrenal and gonadal androgen levels also occur naturally in both sexes. At present, it is unclear if a woman's low serum androgen level is a reflection of the expected normal age-related decline or indicative of an underlying androgen-deficient state. We studied premenopausal women with no complaints of sexual dysfunction to help define a normal female androgen profile. In all, 60 healthy, normally menstruating women, ages 20-49 y, were studied. The Abbreviated Sexual Function Questionnaire was administered along with a detailed interview. Radioimmunoassay measurements of morning serum testosterone (T), free testosterone (fT), dehydroepiandrosterone-sulfate (DHEAS), sex hormone-binding globulin (SHBG), and free androgen index (FAI) were measured during days 8-15 of the menstrual cycle. In women 20-49 y old without complaints of sexual dysfunction, serum androgen levels exhibit a progressive stepwise decline. Comparing values obtained in women age 20-29 y to those obtained in women 40-49 y, specific hormone decrements were DHEAS 195.6-140.4 microg/dl, serum T 51.5-33.7 ng/dl, fT 1.51-1.03 pg/ml. SHBG did not change significantly in women in this age group. The FAI reflected the age-related decrease in female androgen levels. The framework for the development of a female androgen profile in women with no complaints of sexual dysfunction has been established, and an age-related decrease in testosterone and its adrenal precursor, DHEAS, has been demonstrated. The FAI mirrors these decreases and its usefulness in clinical practice is confirmed. A precipitous decline in all androgens occurs after the decade of the 20s, yet SHBG does not show a significant change throughout the premenopausal years. SN - 0955-9930 UR - https://www.unboundmedicine.com/medline/citation/14999217/Serum_androgen_levels_in_healthy_premenopausal_women_with_and_without_sexual_dysfunction:_Part_A__Serum_androgen_levels_in_women_aged_20_49_years_with_no_complaints_of_sexual_dysfunction_ DB - PRIME DP - Unbound Medicine ER -