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Fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis: low birth weight and central HPA regulation.
J Clin Endocrinol Metab. 2004 Mar; 89(3):1227-33.JC

Abstract

Fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as an intermediary in the association between reduced fetal growth and adult cardiovascular and metabolic diseases. Previous studies have shown that small size at birth is associated with increased fasting plasma cortisol and adrenal responsiveness to ACTH stimulation. We have extended these studies by evaluating the salivary cortisol response to awakening and plasma ACTH and cortisol responses to CRH stimulation and a dexamethasone-suppressed CRH (DEX/CRH) test in a group of low birth weight [LBW; <3.18 kg (7 lb), n = 58] and high birth weight [>3.86 kg (8.5 lb), n = 65] men aged 60-69 yr. Despite no difference in basal pituitary-adrenal activity or in their ACTH and cortisol responses to CRH, LBW men had significantly lower pituitary-adrenal responses in the DEX/CRH test. Although these findings do not explain the HPA abnormalities associated with LBW in previous studies, they provide further evidence of dysregulation of the HPA axis in people who were small at birth.

Authors+Show Affiliations

Medical Research Council Environmental Epidemiology Unit, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15001615

Citation

Ward, Alexandra M V., et al. "Fetal Programming of the Hypothalamic-pituitary-adrenal (HPA) Axis: Low Birth Weight and Central HPA Regulation." The Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 3, 2004, pp. 1227-33.
Ward AM, Syddall HE, Wood PJ, et al. Fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis: low birth weight and central HPA regulation. J Clin Endocrinol Metab. 2004;89(3):1227-33.
Ward, A. M., Syddall, H. E., Wood, P. J., Chrousos, G. P., & Phillips, D. I. (2004). Fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis: low birth weight and central HPA regulation. The Journal of Clinical Endocrinology and Metabolism, 89(3), 1227-33.
Ward AM, et al. Fetal Programming of the Hypothalamic-pituitary-adrenal (HPA) Axis: Low Birth Weight and Central HPA Regulation. J Clin Endocrinol Metab. 2004;89(3):1227-33. PubMed PMID: 15001615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis: low birth weight and central HPA regulation. AU - Ward,Alexandra M V, AU - Syddall,Holly E, AU - Wood,Peter J, AU - Chrousos,George P, AU - Phillips,David I W, PY - 2004/3/6/pubmed PY - 2004/4/3/medline PY - 2004/3/6/entrez SP - 1227 EP - 33 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 89 IS - 3 N2 - Fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as an intermediary in the association between reduced fetal growth and adult cardiovascular and metabolic diseases. Previous studies have shown that small size at birth is associated with increased fasting plasma cortisol and adrenal responsiveness to ACTH stimulation. We have extended these studies by evaluating the salivary cortisol response to awakening and plasma ACTH and cortisol responses to CRH stimulation and a dexamethasone-suppressed CRH (DEX/CRH) test in a group of low birth weight [LBW; <3.18 kg (7 lb), n = 58] and high birth weight [>3.86 kg (8.5 lb), n = 65] men aged 60-69 yr. Despite no difference in basal pituitary-adrenal activity or in their ACTH and cortisol responses to CRH, LBW men had significantly lower pituitary-adrenal responses in the DEX/CRH test. Although these findings do not explain the HPA abnormalities associated with LBW in previous studies, they provide further evidence of dysregulation of the HPA axis in people who were small at birth. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/15001615/Fetal_programming_of_the_hypothalamic_pituitary_adrenal__HPA__axis:_low_birth_weight_and_central_HPA_regulation_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2003-030978 DB - PRIME DP - Unbound Medicine ER -