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Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses.
Science. 2004 Mar 05; 303(5663):1508-11.Sci

Abstract

Activity-dependent plasticity in the brain arises in part from changes in the number of synaptic AMPA receptors. Synaptic trafficking of AMPA receptors is controlled by stargazin and homologous transmembrane AMPA receptor regulatory proteins (TARPs). We found that TARPs were stable at the plasma membrane, whereas AMPA receptors were internalized in a glutamate-regulated manner. Interaction with AMPA receptors involved both extra- and intracellular determinants of TARPs. Upon binding to glutamate, AMPA receptors detached from TARPs. This did not require ion flux or intracellular second messengers. This allosteric mechanism for AMPA receptor dissociation from TARPs may participate in glutamate-mediated internalization of receptors in synaptic plasticity.

Authors+Show Affiliations

Department of Physiology, University of California, San Francisco, San Francisco, CA 94143-2140, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15001777

Citation

Tomita, Susumu, et al. "Dynamic Interaction of Stargazin-like TARPs With Cycling AMPA Receptors at Synapses." Science (New York, N.Y.), vol. 303, no. 5663, 2004, pp. 1508-11.
Tomita S, Fukata M, Nicoll RA, et al. Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science. 2004;303(5663):1508-11.
Tomita, S., Fukata, M., Nicoll, R. A., & Bredt, D. S. (2004). Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science (New York, N.Y.), 303(5663), 1508-11.
Tomita S, et al. Dynamic Interaction of Stargazin-like TARPs With Cycling AMPA Receptors at Synapses. Science. 2004 Mar 5;303(5663):1508-11. PubMed PMID: 15001777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. AU - Tomita,Susumu, AU - Fukata,Masaki, AU - Nicoll,Roger A, AU - Bredt,David S, PY - 2004/3/6/pubmed PY - 2004/3/26/medline PY - 2004/3/6/entrez SP - 1508 EP - 11 JF - Science (New York, N.Y.) JO - Science VL - 303 IS - 5663 N2 - Activity-dependent plasticity in the brain arises in part from changes in the number of synaptic AMPA receptors. Synaptic trafficking of AMPA receptors is controlled by stargazin and homologous transmembrane AMPA receptor regulatory proteins (TARPs). We found that TARPs were stable at the plasma membrane, whereas AMPA receptors were internalized in a glutamate-regulated manner. Interaction with AMPA receptors involved both extra- and intracellular determinants of TARPs. Upon binding to glutamate, AMPA receptors detached from TARPs. This did not require ion flux or intracellular second messengers. This allosteric mechanism for AMPA receptor dissociation from TARPs may participate in glutamate-mediated internalization of receptors in synaptic plasticity. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/15001777/Dynamic_interaction_of_stargazin_like_TARPs_with_cycling_AMPA_receptors_at_synapses_ L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=15001777 DB - PRIME DP - Unbound Medicine ER -