Tags

Type your tag names separated by a space and hit enter

Treatment of alopecia areata with the 308-nm xenon chloride excimer laser: case report of two successful treatments with the excimer laser.
Lasers Surg Med. 2004; 34(2):86-90.LS

Abstract

BACKGROUND AND OBJECTIVES

Alopecia areata is a common disease of unknown etiology; it causes significant cosmetic and psycho-social distress for most of the people it affects. We report on an innovative form of treatment in two patients with typical alopecia areata on the capillitium.

STUDY DESIGN/PATIENTS AND METHODS

We successfully treated two patients whose alopecia areata had worsened progressively for 3 and 14 weeks. The treatment involved the use of a 308 nm xenon chloride excimer laser (dosage 300-2,300 mJ/cm(2) per session).

RESULTS

After 11 and 12 sessions within a 9-week and 11-week period, the entire affected focus showed homogenous and thick regrowth. No relapse was observed during the follow-up period of 5 and 18 months.

CONCLUSIONS

The use of the excimer laser is an effective, elegant, and safe means of treatment and has good tolerability. Analogous to topical treatment of alopecia areata, the immunosuppressive mechanism of the excimer laser can be interpreted as an induction of T-cell apoptosis. This new means of treatment has yet to be discussed in medical literature. Further studies with greater numbers are needed to assess its potential more precisely and evaluate the excimer laser in treating alopecia areata.

Authors+Show Affiliations

Laserklinik Karlsruhe, Karlsruhe, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15004817

Citation

Gundogan, Cuneyt, et al. "Treatment of Alopecia Areata With the 308-nm Xenon Chloride Excimer Laser: Case Report of Two Successful Treatments With the Excimer Laser." Lasers in Surgery and Medicine, vol. 34, no. 2, 2004, pp. 86-90.
Gundogan C, Greve B, Raulin C. Treatment of alopecia areata with the 308-nm xenon chloride excimer laser: case report of two successful treatments with the excimer laser. Lasers Surg Med. 2004;34(2):86-90.
Gundogan, C., Greve, B., & Raulin, C. (2004). Treatment of alopecia areata with the 308-nm xenon chloride excimer laser: case report of two successful treatments with the excimer laser. Lasers in Surgery and Medicine, 34(2), 86-90.
Gundogan C, Greve B, Raulin C. Treatment of Alopecia Areata With the 308-nm Xenon Chloride Excimer Laser: Case Report of Two Successful Treatments With the Excimer Laser. Lasers Surg Med. 2004;34(2):86-90. PubMed PMID: 15004817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of alopecia areata with the 308-nm xenon chloride excimer laser: case report of two successful treatments with the excimer laser. AU - Gundogan,Cuneyt, AU - Greve,Bärbel, AU - Raulin,Christian, PY - 2004/3/9/pubmed PY - 2004/6/23/medline PY - 2004/3/9/entrez SP - 86 EP - 90 JF - Lasers in surgery and medicine JO - Lasers Surg Med VL - 34 IS - 2 N2 - BACKGROUND AND OBJECTIVES: Alopecia areata is a common disease of unknown etiology; it causes significant cosmetic and psycho-social distress for most of the people it affects. We report on an innovative form of treatment in two patients with typical alopecia areata on the capillitium. STUDY DESIGN/PATIENTS AND METHODS: We successfully treated two patients whose alopecia areata had worsened progressively for 3 and 14 weeks. The treatment involved the use of a 308 nm xenon chloride excimer laser (dosage 300-2,300 mJ/cm(2) per session). RESULTS: After 11 and 12 sessions within a 9-week and 11-week period, the entire affected focus showed homogenous and thick regrowth. No relapse was observed during the follow-up period of 5 and 18 months. CONCLUSIONS: The use of the excimer laser is an effective, elegant, and safe means of treatment and has good tolerability. Analogous to topical treatment of alopecia areata, the immunosuppressive mechanism of the excimer laser can be interpreted as an induction of T-cell apoptosis. This new means of treatment has yet to be discussed in medical literature. Further studies with greater numbers are needed to assess its potential more precisely and evaluate the excimer laser in treating alopecia areata. SN - 0196-8092 UR - https://www.unboundmedicine.com/medline/citation/15004817/Treatment_of_alopecia_areata_with_the_308_nm_xenon_chloride_excimer_laser:_case_report_of_two_successful_treatments_with_the_excimer_laser_ L2 - https://doi.org/10.1002/lsm.20002 DB - PRIME DP - Unbound Medicine ER -