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Why Eve is not Adam: prospective follow-up in 149650 women and men of cholesterol and other risk factors related to cardiovascular and all-cause mortality.
J Womens Health (Larchmt). 2004 Jan-Feb; 13(1):41-53.JW

Abstract

PURPOSE

To assess the impact of sex-specific patterns in cholesterol levels on all-cause and cardiovascular mortality in the Vorarlberg Health Monitoring and Promotion Programme (VHM&PP).

METHODS

In this study, 67413 men and 82237 women (aged 20-95 years) underwent 454448 standardized examinations, which included measures of blood pressure, height, weight, and fasting samples for cholesterol, triglycerides, gamma-glutamyl transferase (GGT), and glucose in the 15-year period 1985-1999. Relations between these variables and risk of death were analyzed using two approaches of multivariate analyses (Cox proportional hazard and GEE models).

RESULTS

Patterns of cholesterol levels showed marked differences between men and women in relation to age and cause of death. The role of high cholesterol in predicting death from coronary heart disease could be confirmed in men of all ages and in women under the age of 50. In men, across the entire age range, although of borderline significance under the age of 50, and in women from the age of 50 onward only, low cholesterol was significantly associated with all-cause mortality, showing significant associations with death through cancer, liver diseases, and mental diseases. Triglycerides > 200 mg/dl had an effect in women 65 years and older but not in men.

CONCLUSIONS

This large-scale population-based study clearly demonstrates the contrasting patterns of cholesterol level in relation to risk, particularly among those less well studied previously, that is, women of all ages and younger people of both sexes. For the first time, we demonstrate that the low cholesterol effect occurs even among younger respondents, contradicting the previous assessments among cohorts of older people that this is a proxy or marker for frailty occurring with age.

Authors+Show Affiliations

Institute of Biostatistics and Documentation, Leopold Franzens University of Innsbruck, Innsbruck, Austria. Hanno.Ulmer@uibk.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15006277

Citation

Ulmer, Hanno, et al. "Why Eve Is Not Adam: Prospective Follow-up in 149650 Women and Men of Cholesterol and Other Risk Factors Related to Cardiovascular and All-cause Mortality." Journal of Women's Health (2002), vol. 13, no. 1, 2004, pp. 41-53.
Ulmer H, Kelleher C, Diem G, et al. Why Eve is not Adam: prospective follow-up in 149650 women and men of cholesterol and other risk factors related to cardiovascular and all-cause mortality. J Womens Health (Larchmt). 2004;13(1):41-53.
Ulmer, H., Kelleher, C., Diem, G., & Concin, H. (2004). Why Eve is not Adam: prospective follow-up in 149650 women and men of cholesterol and other risk factors related to cardiovascular and all-cause mortality. Journal of Women's Health (2002), 13(1), 41-53.
Ulmer H, et al. Why Eve Is Not Adam: Prospective Follow-up in 149650 Women and Men of Cholesterol and Other Risk Factors Related to Cardiovascular and All-cause Mortality. J Womens Health (Larchmt). 2004;13(1):41-53. PubMed PMID: 15006277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Why Eve is not Adam: prospective follow-up in 149650 women and men of cholesterol and other risk factors related to cardiovascular and all-cause mortality. AU - Ulmer,Hanno, AU - Kelleher,Cecily, AU - Diem,Günter, AU - Concin,Hans, PY - 2004/3/10/pubmed PY - 2004/5/27/medline PY - 2004/3/10/entrez SP - 41 EP - 53 JF - Journal of women's health (2002) JO - J Womens Health (Larchmt) VL - 13 IS - 1 N2 - PURPOSE: To assess the impact of sex-specific patterns in cholesterol levels on all-cause and cardiovascular mortality in the Vorarlberg Health Monitoring and Promotion Programme (VHM&PP). METHODS: In this study, 67413 men and 82237 women (aged 20-95 years) underwent 454448 standardized examinations, which included measures of blood pressure, height, weight, and fasting samples for cholesterol, triglycerides, gamma-glutamyl transferase (GGT), and glucose in the 15-year period 1985-1999. Relations between these variables and risk of death were analyzed using two approaches of multivariate analyses (Cox proportional hazard and GEE models). RESULTS: Patterns of cholesterol levels showed marked differences between men and women in relation to age and cause of death. The role of high cholesterol in predicting death from coronary heart disease could be confirmed in men of all ages and in women under the age of 50. In men, across the entire age range, although of borderline significance under the age of 50, and in women from the age of 50 onward only, low cholesterol was significantly associated with all-cause mortality, showing significant associations with death through cancer, liver diseases, and mental diseases. Triglycerides > 200 mg/dl had an effect in women 65 years and older but not in men. CONCLUSIONS: This large-scale population-based study clearly demonstrates the contrasting patterns of cholesterol level in relation to risk, particularly among those less well studied previously, that is, women of all ages and younger people of both sexes. For the first time, we demonstrate that the low cholesterol effect occurs even among younger respondents, contradicting the previous assessments among cohorts of older people that this is a proxy or marker for frailty occurring with age. SN - 1540-9996 UR - https://www.unboundmedicine.com/medline/citation/15006277/Why_Eve_is_not_Adam:_prospective_follow_up_in_149650_women_and_men_of_cholesterol_and_other_risk_factors_related_to_cardiovascular_and_all_cause_mortality_ L2 - https://www.liebertpub.com/doi/full/10.1089/154099904322836447?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -