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Environmental factors in Helicobacter pylori-related gastric precancerous lesions in Venezuela.

Abstract

Although Helicobacter pylori (HP) infection has been acknowledged to play an etiological role in gastric carcinogenesis, its relatively weak association particularly in developing countries suggests critical roles of cofactors. Among a population with an extremely high prevalence of HP infection (approximately 95%) in Venezuela, we examined the relationship of household characteristics, smoking, alcohol drinking, dietary consumption, and plasma nutrient levels with the prevalence of three different stages of gastric precancerous lesions, chronic atrophic gastritis (AG; n = 337), intestinal metaplasia (IM; n = 551), and dysplasia (n = 157), in comparison with those without any of these lesions (n = 1154). Length of refrigerator use was marginally inversely associated with the prevalence of the precursor lesions studied. The association was most pronounced for AG followed by dysplasia. On the other hand, smoking status was a significant predictor for IM and dysplasia. Those smoking >/=>10 cigarettes/day had 1.8-fold risk of IM and 3.6-fold risk of dysplasia compared with never smokers. There were no associations with alcohol consumption. When six food groups known to be associated with stomach cancer risk in Venezuela were tested, the prevalence of these lesions progressively increased with increasing starchy vegetable consumption and decreasing fresh fruit/fruit juice consumption. The association with fruits was more evident for dysplasia and AG and that with starchy vegetables for IM and AG. However, there were no inverse associations with plasma antioxidant vitamins. These findings offer important public health implications in preventing progression of HP-associated gastric precancerous lesions in high-risk populations.

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  • Authors+Show Affiliations

    ,

    Karmanos Cancer Institute/Department of Pathology, Wayne State University, Detroit MI, USA. katoi@med.wayne.edu

    , , , , , , , , , , ,

    Source

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Case-Control Studies
    Developing Countries
    Diet
    Environment
    Female
    Fruit
    Gastritis, Atrophic
    Helicobacter Infections
    Helicobacter pylori
    Humans
    Male
    Metaplasia
    Middle Aged
    Nutritional Status
    Precancerous Conditions
    Risk Factors
    Stomach
    Stomach Neoplasms
    Vegetables
    Venezuela

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15006925

    Citation

    Kato, Ikuko, et al. "Environmental Factors in Helicobacter Pylori-related Gastric Precancerous Lesions in Venezuela." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 13, no. 3, 2004, pp. 468-76.
    Kato I, Vivas J, Plummer M, et al. Environmental factors in Helicobacter pylori-related gastric precancerous lesions in Venezuela. Cancer Epidemiol Biomarkers Prev. 2004;13(3):468-76.
    Kato, I., Vivas, J., Plummer, M., Lopez, G., Peraza, S., Castro, D., ... Muñoz, N. (2004). Environmental factors in Helicobacter pylori-related gastric precancerous lesions in Venezuela. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 13(3), pp. 468-76.
    Kato I, et al. Environmental Factors in Helicobacter Pylori-related Gastric Precancerous Lesions in Venezuela. Cancer Epidemiol Biomarkers Prev. 2004;13(3):468-76. PubMed PMID: 15006925.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Environmental factors in Helicobacter pylori-related gastric precancerous lesions in Venezuela. AU - Kato,Ikuko, AU - Vivas,Jorge, AU - Plummer,Martyn, AU - Lopez,Gladys, AU - Peraza,Simon, AU - Castro,Dennis, AU - Sanchez,Victor, AU - Cano,Elsa, AU - Andrade,Olga, AU - Garcia,Rita, AU - Franceschi,Silvia, AU - Oliver,Walter, AU - Muñoz,Nubia, PY - 2004/3/10/pubmed PY - 2004/6/2/medline PY - 2004/3/10/entrez SP - 468 EP - 76 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 13 IS - 3 N2 - Although Helicobacter pylori (HP) infection has been acknowledged to play an etiological role in gastric carcinogenesis, its relatively weak association particularly in developing countries suggests critical roles of cofactors. Among a population with an extremely high prevalence of HP infection (approximately 95%) in Venezuela, we examined the relationship of household characteristics, smoking, alcohol drinking, dietary consumption, and plasma nutrient levels with the prevalence of three different stages of gastric precancerous lesions, chronic atrophic gastritis (AG; n = 337), intestinal metaplasia (IM; n = 551), and dysplasia (n = 157), in comparison with those without any of these lesions (n = 1154). Length of refrigerator use was marginally inversely associated with the prevalence of the precursor lesions studied. The association was most pronounced for AG followed by dysplasia. On the other hand, smoking status was a significant predictor for IM and dysplasia. Those smoking >/=>10 cigarettes/day had 1.8-fold risk of IM and 3.6-fold risk of dysplasia compared with never smokers. There were no associations with alcohol consumption. When six food groups known to be associated with stomach cancer risk in Venezuela were tested, the prevalence of these lesions progressively increased with increasing starchy vegetable consumption and decreasing fresh fruit/fruit juice consumption. The association with fruits was more evident for dysplasia and AG and that with starchy vegetables for IM and AG. However, there were no inverse associations with plasma antioxidant vitamins. These findings offer important public health implications in preventing progression of HP-associated gastric precancerous lesions in high-risk populations. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15006925/Environmental_factors_in_Helicobacter_pylori_related_gastric_precancerous_lesions_in_Venezuela_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=15006925 DB - PRIME DP - Unbound Medicine ER -