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What does postprandial hyperglycaemia mean?
Diabet Med. 2004 Mar; 21(3):208-13.DM

Abstract

AIMS

The potential importance of postprandial glucose (PPG) control in the development of complications in Type 2 diabetes is much debated. The recent American Diabetes Association (ADA) consensus statement discussed the role of postprandial hyperglycaemia in the pathogenesis of diabetic complications and concluded that the relationship between PPG excursions and the well-established risk factors for cardiovascular disease (CVD) should be further examined. Using the ADA statement as a starting point and including the more recent American College of Endocrinology guidelines on glycaemic control, a panel of experts in diabetes met to review the role of PPG within the context of the overall metabolic syndrome, in the development of complications in Type 2 diabetes.

RESULTS

Post-prandial hyperglycaemia is a risk indicator for micro- and macrovascular complications, not only in patients with Type 2 diabetes but also in those with impaired glucose tolerance. In addition, the metabolic syndrome confers an increased risk of CVD morbidity and mortality. The debate focused on the relative contributions of postprandial hyperglycaemia, the metabolic syndrome and, in particular, raised triglyceride levels in the postprandial state, to the development of cardiovascular complications of diabetes.

CONCLUSIONS

The panel recommended that in the prevention and management of microvascular complications of Type 2 diabetes, targeting both chronic and acute glucose fluctuations is necessary. Lowering the macrovascular risk also requires control of (postprandial) triglyceride levels and other components of the metabolic syndrome.

Authors+Show Affiliations

Heine RJ
Panel Chair, Diabetes Centre, VU University Medical Centre, Amsterdam, the Netherlands. rj.heine@vumc.nl
Balkau B
No affiliation info available
Ceriello A
No affiliation info available
Del Prato S
No affiliation info available
Horton ES
No affiliation info available
Taskinen MR
No affiliation info available

MeSH

Blood GlucoseDiabetes Mellitus, Type 2Diabetic AngiopathiesGlycated HemoglobinHumansHyperglycemiaInsulin ResistanceMetabolic SyndromePostprandial PeriodRisk FactorsTriglycerides

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15008828

Clinical Trial Links

Is Mid-morning Breakfast as Healthy as Early-morning Breakfast for Blood Sugar Control in Adolescent Girls?

Citation

Heine, R J., et al. "What Does Postprandial Hyperglycaemia Mean?" Diabetic Medicine : a Journal of the British Diabetic Association, vol. 21, no. 3, 2004, pp. 208-13.
Heine RJ, Balkau B, Ceriello A, et al. What does postprandial hyperglycaemia mean? Diabet Med. 2004;21(3):208-13.
Heine, R. J., Balkau, B., Ceriello, A., Del Prato, S., Horton, E. S., & Taskinen, M. R. (2004). What does postprandial hyperglycaemia mean? Diabetic Medicine : a Journal of the British Diabetic Association, 21(3), 208-13.
Heine RJ, et al. What Does Postprandial Hyperglycaemia Mean. Diabet Med. 2004;21(3):208-13. PubMed PMID: 15008828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What does postprandial hyperglycaemia mean? AU - Heine,R J, AU - Balkau,B, AU - Ceriello,A, AU - Del Prato,S, AU - Horton,E S, AU - Taskinen,M-R, PY - 2004/3/11/pubmed PY - 2004/5/25/medline PY - 2004/3/11/entrez SP - 208 EP - 13 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 21 IS - 3 N2 - AIMS: The potential importance of postprandial glucose (PPG) control in the development of complications in Type 2 diabetes is much debated. The recent American Diabetes Association (ADA) consensus statement discussed the role of postprandial hyperglycaemia in the pathogenesis of diabetic complications and concluded that the relationship between PPG excursions and the well-established risk factors for cardiovascular disease (CVD) should be further examined. Using the ADA statement as a starting point and including the more recent American College of Endocrinology guidelines on glycaemic control, a panel of experts in diabetes met to review the role of PPG within the context of the overall metabolic syndrome, in the development of complications in Type 2 diabetes. RESULTS: Post-prandial hyperglycaemia is a risk indicator for micro- and macrovascular complications, not only in patients with Type 2 diabetes but also in those with impaired glucose tolerance. In addition, the metabolic syndrome confers an increased risk of CVD morbidity and mortality. The debate focused on the relative contributions of postprandial hyperglycaemia, the metabolic syndrome and, in particular, raised triglyceride levels in the postprandial state, to the development of cardiovascular complications of diabetes. CONCLUSIONS: The panel recommended that in the prevention and management of microvascular complications of Type 2 diabetes, targeting both chronic and acute glucose fluctuations is necessary. Lowering the macrovascular risk also requires control of (postprandial) triglyceride levels and other components of the metabolic syndrome. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/15008828/What_does_postprandial_hyperglycaemia_mean DB - PRIME DP - Unbound Medicine ER -