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Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Behçet's disease.
Eur J Immunogenet. 2004 Feb; 31(1):11-4.EJ

Abstract

Chemokines are important determinants of the early inflammatory response. The CC chemokine receptor 5 (CCR5) Delta32 variant results in a non-functional form of the chemokine receptor, and has been implicated in a variety of immune-mediated diseases. To investigate its role in the pathogenesis of Behçet's disease, we studied 350 patients and 519 healthy controls from three ethnic groups. While significant inter-ethnic variation in allele frequency was observed, no association was identified with disease, even when data were stratified by the known susceptibility gene HLA-B*51.

Authors+Show Affiliations

Gastroenterology Unit, University of Oxford, Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15009175

Citation

Yang, X, et al. "Analysis of the CC Chemokine Receptor 5 (CCR5) Delta32 Polymorphism in Behçet's Disease." European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics, vol. 31, no. 1, 2004, pp. 11-4.
Yang X, Ahmad T, Gogus F, et al. Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Behçet's disease. Eur J Immunogenet. 2004;31(1):11-4.
Yang, X., Ahmad, T., Gogus, F., Verity, D., Wallace, G. R., Madanat, W., Kanawati, C. A., Stanford, M. R., Fortune, F., Jewell, D. P., & Marshall, S. E. (2004). Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Behçet's disease. European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics, 31(1), 11-4.
Yang X, et al. Analysis of the CC Chemokine Receptor 5 (CCR5) Delta32 Polymorphism in Behçet's Disease. Eur J Immunogenet. 2004;31(1):11-4. PubMed PMID: 15009175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Behçet's disease. AU - Yang,X, AU - Ahmad,T, AU - Gogus,F, AU - Verity,D, AU - Wallace,G R, AU - Madanat,W, AU - Kanawati,C A, AU - Stanford,M R, AU - Fortune,F, AU - Jewell,D P, AU - Marshall,S E, PY - 2004/3/11/pubmed PY - 2004/10/20/medline PY - 2004/3/11/entrez SP - 11 EP - 4 JF - European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics JO - Eur. J. Immunogenet. VL - 31 IS - 1 N2 - Chemokines are important determinants of the early inflammatory response. The CC chemokine receptor 5 (CCR5) Delta32 variant results in a non-functional form of the chemokine receptor, and has been implicated in a variety of immune-mediated diseases. To investigate its role in the pathogenesis of Behçet's disease, we studied 350 patients and 519 healthy controls from three ethnic groups. While significant inter-ethnic variation in allele frequency was observed, no association was identified with disease, even when data were stratified by the known susceptibility gene HLA-B*51. SN - 0960-7420 UR - https://www.unboundmedicine.com/medline/citation/15009175/Analysis_of_the_CC_chemokine_receptor_5__CCR5__Delta32_polymorphism_in_Behçet's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0960-7420&date=2004&volume=31&issue=1&spage=11 DB - PRIME DP - Unbound Medicine ER -