Tags

Type your tag names separated by a space and hit enter

[An epidemic of hemorrhagic fever with renal syndrome at the therapeutic community for treatment of psychoactive drug dependence in Ivanovac].
Acta Med Croatica. 2003; 57(5):361-4.AM

Abstract

GOAL

The outbreak of hemorrhagic fever with renal syndrome (HFRS) at the Ivanovac Drug Therapeutic Community near Nova Gradiska was analyzed. The major epidemiologic, clinical and serologic findings are presented.

PATIENTS AND METHODS

During the HFRS outbreak, serum samples were obtained from 31 men from the Community and analyzed by ELISA IgM and IgG tests for Puumala (PUUV) and Dobrava (DOBV) viruses. The main epidemiologic and clinical data were analyzed.

RESULTS

At the beginning of March 2002, a-30-year-old male from the Community developed severe clinical picture of HFRS with fulminant systemic hemorrhage, acute renal failure and consecutive death. IgM antibodies to DOBV were detected. HFRS was serologically confirmed in 15 subjects in total. All others were infected with PUUV. During the mild and dry winter, the Community members cut bushes, collected trash, branches and dry leaves near the beech-wood forest border to prepare that part of the field as a garden. They observed a number of rodents, their nests and holes. Most of the patients developed mild to moderate clinical picture with fever, headache, backache, myalgia, abdominal pain, melena, oliguria, polyuria, epistaxis, and conjunctival injection. Hepatitis B (HBV) and/or C (HCV) infection was recorded in 58.1% of Community members. Interestingly, 86.7% of the HFRS patients were HBV and/or HCV positive.

CONCLUSIONS

This is the first HFRS outbreak described among drug addicts in Europe, mostly caused by PUUV. Further studies are needed to identify additional risk factors that may contribute to hantavirus infection among drug addicts in HFRS endemic regions in Croatia as well as in Europe.

Authors+Show Affiliations

Zavod za javno zdravstvo Zupanije brodsko-posavske Nazorova b. b. 35000 Slavonski Brod, Hrvatska.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

hrv

PubMed ID

15011461

Citation

Miletić-Medved, Marica, et al. "[An Epidemic of Hemorrhagic Fever With Renal Syndrome at the Therapeutic Community for Treatment of Psychoactive Drug Dependence in Ivanovac]." Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti, vol. 57, no. 5, 2003, pp. 361-4.
Miletić-Medved M, Markotić A, Kuzman I, et al. [An epidemic of hemorrhagic fever with renal syndrome at the therapeutic community for treatment of psychoactive drug dependence in Ivanovac]. Acta Med Croatica. 2003;57(5):361-4.
Miletić-Medved, M., Markotić, A., Kuzman, I., Marić, Z., & Avsic-Zupanc, T. (2003). [An epidemic of hemorrhagic fever with renal syndrome at the therapeutic community for treatment of psychoactive drug dependence in Ivanovac]. Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti, 57(5), 361-4.
Miletić-Medved M, et al. [An Epidemic of Hemorrhagic Fever With Renal Syndrome at the Therapeutic Community for Treatment of Psychoactive Drug Dependence in Ivanovac]. Acta Med Croatica. 2003;57(5):361-4. PubMed PMID: 15011461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [An epidemic of hemorrhagic fever with renal syndrome at the therapeutic community for treatment of psychoactive drug dependence in Ivanovac]. AU - Miletić-Medved,Marica, AU - Markotić,Alemka, AU - Kuzman,Ilija, AU - Marić,Zorana, AU - Avsic-Zupanc,Tatjana, PY - 2004/3/12/pubmed PY - 2004/4/2/medline PY - 2004/3/12/entrez SP - 361 EP - 4 JF - Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti JO - Acta Med Croatica VL - 57 IS - 5 N2 - GOAL: The outbreak of hemorrhagic fever with renal syndrome (HFRS) at the Ivanovac Drug Therapeutic Community near Nova Gradiska was analyzed. The major epidemiologic, clinical and serologic findings are presented. PATIENTS AND METHODS: During the HFRS outbreak, serum samples were obtained from 31 men from the Community and analyzed by ELISA IgM and IgG tests for Puumala (PUUV) and Dobrava (DOBV) viruses. The main epidemiologic and clinical data were analyzed. RESULTS: At the beginning of March 2002, a-30-year-old male from the Community developed severe clinical picture of HFRS with fulminant systemic hemorrhage, acute renal failure and consecutive death. IgM antibodies to DOBV were detected. HFRS was serologically confirmed in 15 subjects in total. All others were infected with PUUV. During the mild and dry winter, the Community members cut bushes, collected trash, branches and dry leaves near the beech-wood forest border to prepare that part of the field as a garden. They observed a number of rodents, their nests and holes. Most of the patients developed mild to moderate clinical picture with fever, headache, backache, myalgia, abdominal pain, melena, oliguria, polyuria, epistaxis, and conjunctival injection. Hepatitis B (HBV) and/or C (HCV) infection was recorded in 58.1% of Community members. Interestingly, 86.7% of the HFRS patients were HBV and/or HCV positive. CONCLUSIONS: This is the first HFRS outbreak described among drug addicts in Europe, mostly caused by PUUV. Further studies are needed to identify additional risk factors that may contribute to hantavirus infection among drug addicts in HFRS endemic regions in Croatia as well as in Europe. SN - 1330-0164 UR - https://www.unboundmedicine.com/medline/citation/15011461/[An_epidemic_of_hemorrhagic_fever_with_renal_syndrome_at_the_therapeutic_community_for_treatment_of_psychoactive_drug_dependence_in_Ivanovac]_ L2 - http://www.diseaseinfosearch.org/result/3317 DB - PRIME DP - Unbound Medicine ER -