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Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice.

Abstract

To elucidate the anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, female ICR mice were fed on diets containing 2% green tea powder and diets containing 0.3% catechins, 0.05% caffeine and 0.03% theanine, which correspond, respectively, to their concentrations in a 2% green tea powder diet, singly and in combination for 16 weeks. Body weight and food intake were determined monthly during this period, kidneys, adrenals, liver, spleen, brain, pituitary and intraperitoneal adipose tissues (IPAT) were weighed and lipid levels in the serum and liver were measured at the end of this period. The body weight increase and weight of IPAT were significantly reduced by the diets containing green tea, caffeine, theanine, caffeine + catechins, caffeine + theanine and caffeine + catechins + theanine. Noticeably, the IPAT weight decreased by 76.8% in the caffeine + catechins compared to the control group. Serum concentrations of triglycerides (TG) and non-esterified fatty acids (NEFA) were decreased by green tea, catechins and theanine. Moreover, caffeine + catechins, caffeine + theanine and caffeine + catechins + theanine also decreased NEFA in the serum. The TG level in the liver was significantly reduced by catechins and catechins + theanine in comparison with the control. These results indicated that at least caffeine and theanine were responsible for the suppressive effect of green tea powder (GTP) on body weight increase and fat accumulation. Moreover, it was shown that catechins and caffeine were synergistic in anti-obesity activities.

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  • Authors+Show Affiliations

    ,

    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka-shi 422-8529, Japan.

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    Source

    MeSH

    Adipose Tissue
    Animals
    Anti-Obesity Agents
    Body Weight
    Caffeine
    Catechin
    Eating
    Female
    Glutamates
    Mice
    Mice, Inbred ICR
    Tea

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15011752

    Citation

    Zheng, Guodong, et al. "Anti-obesity Effects of Three Major Components of Green Tea, Catechins, Caffeine and Theanine, in Mice." In Vivo (Athens, Greece), vol. 18, no. 1, 2004, pp. 55-62.
    Zheng G, Sayama K, Okubo T, et al. Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice. In Vivo. 2004;18(1):55-62.
    Zheng, G., Sayama, K., Okubo, T., Juneja, L. R., & Oguni, I. (2004). Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice. In Vivo (Athens, Greece), 18(1), pp. 55-62.
    Zheng G, et al. Anti-obesity Effects of Three Major Components of Green Tea, Catechins, Caffeine and Theanine, in Mice. In Vivo. 2004;18(1):55-62. PubMed PMID: 15011752.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice. AU - Zheng,Guodong, AU - Sayama,Kazutoshi, AU - Okubo,Tsutomu, AU - Juneja,Lekh Raj, AU - Oguni,Itaro, PY - 2004/3/12/pubmed PY - 2004/10/8/medline PY - 2004/3/12/entrez SP - 55 EP - 62 JF - In vivo (Athens, Greece) JO - In Vivo VL - 18 IS - 1 N2 - To elucidate the anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, female ICR mice were fed on diets containing 2% green tea powder and diets containing 0.3% catechins, 0.05% caffeine and 0.03% theanine, which correspond, respectively, to their concentrations in a 2% green tea powder diet, singly and in combination for 16 weeks. Body weight and food intake were determined monthly during this period, kidneys, adrenals, liver, spleen, brain, pituitary and intraperitoneal adipose tissues (IPAT) were weighed and lipid levels in the serum and liver were measured at the end of this period. The body weight increase and weight of IPAT were significantly reduced by the diets containing green tea, caffeine, theanine, caffeine + catechins, caffeine + theanine and caffeine + catechins + theanine. Noticeably, the IPAT weight decreased by 76.8% in the caffeine + catechins compared to the control group. Serum concentrations of triglycerides (TG) and non-esterified fatty acids (NEFA) were decreased by green tea, catechins and theanine. Moreover, caffeine + catechins, caffeine + theanine and caffeine + catechins + theanine also decreased NEFA in the serum. The TG level in the liver was significantly reduced by catechins and catechins + theanine in comparison with the control. These results indicated that at least caffeine and theanine were responsible for the suppressive effect of green tea powder (GTP) on body weight increase and fat accumulation. Moreover, it was shown that catechins and caffeine were synergistic in anti-obesity activities. SN - 0258-851X UR - https://www.unboundmedicine.com/medline/citation/15011752/Anti_obesity_effects_of_three_major_components_of_green_tea_catechins_caffeine_and_theanine_in_mice_ L2 - http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=15011752 DB - PRIME DP - Unbound Medicine ER -