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Clinical and pathological prognostic indicators with colorectal mucinous carcinomas.
Hepatogastroenterology. 2004 Jan-Feb; 51(55):142-6.H

Abstract

BACKGROUND/AIMS

Colorectal mucinous carcinomas are considered to have a worse prognosis than typical adenocarcinomas. To evaluate the prognostic relevance of a series of clinical and pathological variables, patients with colorectal mucinous carcinomas were studied retrospectively.

METHODOLOGY

Ninety-eight patients who underwent surgery for colorectal mucinous carcinomas were included in this study. We firstly examined whether signet-ring cell carcinomas exhibited worse prognosis than the other mucinous carcinomas. Prognostic factors were then analyzed by both univariate and multivariate analysis for 70 patients who underwent complete resection.

RESULTS

The overall five-year survival rate was 44%. Amount of signet-ring cells was a non-significant indicator of poor prognosis. For the cases whose cancers were completely resected, four parameters (liver metastasis, lymph node involvement, vessel involvement, spread beyond the bowel wall) were significantly related to prognosis on univariate analysis. With the multivariate analysis, liver metastasis and spread beyond the bowel wall were independent variables.

CONCLUSIONS

This study reaffirmed the importance of liver metastasis and spread beyond the bowel wall for prediction of prognosis with colorectal mucinous carcinomas for cases who undergo complete resection. In addition, the presence of signet-ring cells is a non-significant indicator of a poor prognosis.

Authors+Show Affiliations

Kubota K
Department of Surgery, National Cancer Center Hospital, Tokyo, Japan.
Akasu T
No affiliation info available
Fujita S
No affiliation info available
Sugihara K
No affiliation info available
Moriya Y
No affiliation info available
Yamamoto S
No affiliation info available

MeSH

Adenocarcinoma, MucinousAdultAgedAged, 80 and overCarcinoma, Signet Ring CellColonic NeoplasmsFemaleHumansLiver NeoplasmsLymphatic MetastasisMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessPrognosisRectal Neoplasms

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15011850

Citation

Kubota, Keisuke, et al. "Clinical and Pathological Prognostic Indicators With Colorectal Mucinous Carcinomas." Hepato-gastroenterology, vol. 51, no. 55, 2004, pp. 142-6.
Kubota K, Akasu T, Fujita S, et al. Clinical and pathological prognostic indicators with colorectal mucinous carcinomas. Hepatogastroenterology. 2004;51(55):142-6.
Kubota, K., Akasu, T., Fujita, S., Sugihara, K., Moriya, Y., & Yamamoto, S. (2004). Clinical and pathological prognostic indicators with colorectal mucinous carcinomas. Hepato-gastroenterology, 51(55), 142-6.
Kubota K, et al. Clinical and Pathological Prognostic Indicators With Colorectal Mucinous Carcinomas. Hepatogastroenterology. 2004 Jan-Feb;51(55):142-6. PubMed PMID: 15011850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and pathological prognostic indicators with colorectal mucinous carcinomas. AU - Kubota,Keisuke, AU - Akasu,Takayuki, AU - Fujita,Shin, AU - Sugihara,Ken-ichi, AU - Moriya,Yoshihiro, AU - Yamamoto,Seiichiro, PY - 2004/3/12/pubmed PY - 2004/6/21/medline PY - 2004/3/12/entrez SP - 142 EP - 6 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 51 IS - 55 N2 - BACKGROUND/AIMS: Colorectal mucinous carcinomas are considered to have a worse prognosis than typical adenocarcinomas. To evaluate the prognostic relevance of a series of clinical and pathological variables, patients with colorectal mucinous carcinomas were studied retrospectively. METHODOLOGY: Ninety-eight patients who underwent surgery for colorectal mucinous carcinomas were included in this study. We firstly examined whether signet-ring cell carcinomas exhibited worse prognosis than the other mucinous carcinomas. Prognostic factors were then analyzed by both univariate and multivariate analysis for 70 patients who underwent complete resection. RESULTS: The overall five-year survival rate was 44%. Amount of signet-ring cells was a non-significant indicator of poor prognosis. For the cases whose cancers were completely resected, four parameters (liver metastasis, lymph node involvement, vessel involvement, spread beyond the bowel wall) were significantly related to prognosis on univariate analysis. With the multivariate analysis, liver metastasis and spread beyond the bowel wall were independent variables. CONCLUSIONS: This study reaffirmed the importance of liver metastasis and spread beyond the bowel wall for prediction of prognosis with colorectal mucinous carcinomas for cases who undergo complete resection. In addition, the presence of signet-ring cells is a non-significant indicator of a poor prognosis. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/15011850/Clinical_and_pathological_prognostic_indicators_with_colorectal_mucinous_carcinomas_ DB - PRIME DP - Unbound Medicine ER -