Tags

Type your tag names separated by a space and hit enter

Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa.
Org Lett. 2004 Mar 18; 6(6):869-72.OL

Abstract

[structure: see text] Four new dolabellane-type diterpene alkaloids, nigellamines A(1) (1), A(2) (2), B(1) (3), and B(2) (4), were isolated from the seeds of Nigella sativa. Their absolute stereostructures were determined on the basis of chemical and physicochemical evidence. Nigellamines A(1) (1), B(1) (3), and B(2) (4) were found to show potent lipid metabolism promoting activity in primary cultured mouse hepatocytes, and their activities were equivalent to that of a PPAR-alpha agonist, clofibrate.

Authors+Show Affiliations

Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. shoyaku@mb.kuoto-phu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15012052

Citation

Morikawa, Toshio, et al. "Novel Dolabellane-type Diterpene Alkaloids With Lipid Metabolism Promoting Activities From the Seeds of Nigella Sativa." Organic Letters, vol. 6, no. 6, 2004, pp. 869-72.
Morikawa T, Xu F, Kashima Y, et al. Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa. Org Lett. 2004;6(6):869-72.
Morikawa, T., Xu, F., Kashima, Y., Matsuda, H., Ninomiya, K., & Yoshikawa, M. (2004). Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa. Organic Letters, 6(6), 869-72.
Morikawa T, et al. Novel Dolabellane-type Diterpene Alkaloids With Lipid Metabolism Promoting Activities From the Seeds of Nigella Sativa. Org Lett. 2004 Mar 18;6(6):869-72. PubMed PMID: 15012052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa. AU - Morikawa,Toshio, AU - Xu,Fengming, AU - Kashima,Yousuke, AU - Matsuda,Hisashi, AU - Ninomiya,Kiyofumi, AU - Yoshikawa,Masayuki, PY - 2004/3/12/pubmed PY - 2004/12/16/medline PY - 2004/3/12/entrez SP - 869 EP - 72 JF - Organic letters JO - Org Lett VL - 6 IS - 6 N2 - [structure: see text] Four new dolabellane-type diterpene alkaloids, nigellamines A(1) (1), A(2) (2), B(1) (3), and B(2) (4), were isolated from the seeds of Nigella sativa. Their absolute stereostructures were determined on the basis of chemical and physicochemical evidence. Nigellamines A(1) (1), B(1) (3), and B(2) (4) were found to show potent lipid metabolism promoting activity in primary cultured mouse hepatocytes, and their activities were equivalent to that of a PPAR-alpha agonist, clofibrate. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/15012052/Novel_dolabellane_type_diterpene_alkaloids_with_lipid_metabolism_promoting_activities_from_the_seeds_of_Nigella_sativa_ L2 - https://doi.org/10.1021/ol036239c DB - PRIME DP - Unbound Medicine ER -