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Diastereoselective aldol reaction of N,N-dibenzyl-alpha-amino aldehydes with ketones catalyzed by proline.
Org Lett. 2004 Mar 18; 6(6):1009-12.OL

Abstract

[reaction: see text] L-proline-catalyzed direct aldol reaction of L-amino acid-derived N,N-dibenzyl amino aldehydes with acetone, cyclopentanone, or hydroxyacetone provides gamma-amino-beta-hydroxy- or gamma-amino-alpha,beta-dihydroxy-ketones with moderate to excellent yields and diastereoselectivities.

Authors+Show Affiliations

Department of Chemistry, Fudan University, Shanghai 200433, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15012087

Citation

Pan, Qiangbiao, et al. "Diastereoselective Aldol Reaction of N,N-dibenzyl-alpha-amino Aldehydes With Ketones Catalyzed By Proline." Organic Letters, vol. 6, no. 6, 2004, pp. 1009-12.
Pan Q, Zou B, Wang Y, et al. Diastereoselective aldol reaction of N,N-dibenzyl-alpha-amino aldehydes with ketones catalyzed by proline. Org Lett. 2004;6(6):1009-12.
Pan, Q., Zou, B., Wang, Y., & Ma, D. (2004). Diastereoselective aldol reaction of N,N-dibenzyl-alpha-amino aldehydes with ketones catalyzed by proline. Organic Letters, 6(6), 1009-12.
Pan Q, et al. Diastereoselective Aldol Reaction of N,N-dibenzyl-alpha-amino Aldehydes With Ketones Catalyzed By Proline. Org Lett. 2004 Mar 18;6(6):1009-12. PubMed PMID: 15012087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diastereoselective aldol reaction of N,N-dibenzyl-alpha-amino aldehydes with ketones catalyzed by proline. AU - Pan,Qiangbiao, AU - Zou,Benli, AU - Wang,Yuji, AU - Ma,Dawei, PY - 2004/3/12/pubmed PY - 2004/12/16/medline PY - 2004/3/12/entrez SP - 1009 EP - 12 JF - Organic letters JO - Org Lett VL - 6 IS - 6 N2 - [reaction: see text] L-proline-catalyzed direct aldol reaction of L-amino acid-derived N,N-dibenzyl amino aldehydes with acetone, cyclopentanone, or hydroxyacetone provides gamma-amino-beta-hydroxy- or gamma-amino-alpha,beta-dihydroxy-ketones with moderate to excellent yields and diastereoselectivities. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/15012087/Diastereoselective_aldol_reaction_of_NN_dibenzyl_alpha_amino_aldehydes_with_ketones_catalyzed_by_proline_ DB - PRIME DP - Unbound Medicine ER -
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