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BINOL-Salen-catalyzed highly enantioselective alkyne additions to aromatic aldehydes.
Org Lett. 2004 Mar 18; 6(6):1065-8.OL

Abstract

[structure: see text] The BINOL-Salen compound (-)-1 can catalyze the addition of both aryl- and alkylalkynes to aromatic aldehydes at room temperature with high enantioselectivity (86-97% ee). The conditions for this catalytic process are both mild and simple. Unlike most other BINOL-based catalysts, using ligand (-)-1 not only avoids heating or cooling but also does not require the addition of Ti(O(i)Pr)(4).

Authors+Show Affiliations

Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15012101

Citation

Li, Zi-Bo, and Lin Pu. "BINOL-Salen-catalyzed Highly Enantioselective Alkyne Additions to Aromatic Aldehydes." Organic Letters, vol. 6, no. 6, 2004, pp. 1065-8.
Li ZB, Pu L. BINOL-Salen-catalyzed highly enantioselective alkyne additions to aromatic aldehydes. Org Lett. 2004;6(6):1065-8.
Li, Z. B., & Pu, L. (2004). BINOL-Salen-catalyzed highly enantioselective alkyne additions to aromatic aldehydes. Organic Letters, 6(6), 1065-8.
Li ZB, Pu L. BINOL-Salen-catalyzed Highly Enantioselective Alkyne Additions to Aromatic Aldehydes. Org Lett. 2004 Mar 18;6(6):1065-8. PubMed PMID: 15012101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - BINOL-Salen-catalyzed highly enantioselective alkyne additions to aromatic aldehydes. AU - Li,Zi-Bo, AU - Pu,Lin, PY - 2004/3/12/pubmed PY - 2004/12/16/medline PY - 2004/3/12/entrez SP - 1065 EP - 8 JF - Organic letters JO - Org Lett VL - 6 IS - 6 N2 - [structure: see text] The BINOL-Salen compound (-)-1 can catalyze the addition of both aryl- and alkylalkynes to aromatic aldehydes at room temperature with high enantioselectivity (86-97% ee). The conditions for this catalytic process are both mild and simple. Unlike most other BINOL-based catalysts, using ligand (-)-1 not only avoids heating or cooling but also does not require the addition of Ti(O(i)Pr)(4). SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/15012101/BINOL_Salen_catalyzed_highly_enantioselective_alkyne_additions_to_aromatic_aldehydes_ L2 - https://doi.org/10.1021/ol0498139 DB - PRIME DP - Unbound Medicine ER -