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Study of freeze-dried quercetin-cyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis.
J Pharm Biomed Anal. 2004 Feb 04; 34(2):333-9.JP

Abstract

The inclusion behavior of 2-hydroxypropyl beta-cyclodextrin (HPbetaCD) and beta-cyclodextrin (betaCD), in solution and solid-state was studied towards a poorly water-soluble bioflavonoid, quercetin (QURC), chemically 3,3',4',5',7-pentahydroxy flavone. Drug-cyclodextrin solid systems were prepared by freeze-drying. Phase solubility study was used to evaluate the complexation in solution, of two cyclodextrins, i.e., betaCD and HPbetaCD. The stoichiometry and stability constants of QURC-betaCD (1:1 and 402M(-1)) and QURC-HPbetaCD (1:1 and 532M(-1)) complexes were calculated by phase solubility method. The formation of inclusion complexes with betaCD and HPbetaCD in the solid-state were confirmed by infrared spectroscopy, differential scanning calorimetry, X-ray diffractometry, and scanning electron microscopy (SEM).

Authors+Show Affiliations

Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai 400098, India. pralhad_tayade@rediffmail.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15013147

Citation

Pralhad, Tayade, and Kale Rajendrakumar. "Study of Freeze-dried Quercetin-cyclodextrin Binary Systems By DSC, FT-IR, X-ray Diffraction and SEM Analysis." Journal of Pharmaceutical and Biomedical Analysis, vol. 34, no. 2, 2004, pp. 333-9.
Pralhad T, Rajendrakumar K. Study of freeze-dried quercetin-cyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis. J Pharm Biomed Anal. 2004;34(2):333-9.
Pralhad, T., & Rajendrakumar, K. (2004). Study of freeze-dried quercetin-cyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis. Journal of Pharmaceutical and Biomedical Analysis, 34(2), 333-9.
Pralhad T, Rajendrakumar K. Study of Freeze-dried Quercetin-cyclodextrin Binary Systems By DSC, FT-IR, X-ray Diffraction and SEM Analysis. J Pharm Biomed Anal. 2004 Feb 4;34(2):333-9. PubMed PMID: 15013147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of freeze-dried quercetin-cyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis. AU - Pralhad,Tayade, AU - Rajendrakumar,Kale, PY - 2003/05/12/received PY - 2003/09/01/revised PY - 2003/09/09/accepted PY - 2004/3/12/pubmed PY - 2004/10/7/medline PY - 2004/3/12/entrez SP - 333 EP - 9 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 34 IS - 2 N2 - The inclusion behavior of 2-hydroxypropyl beta-cyclodextrin (HPbetaCD) and beta-cyclodextrin (betaCD), in solution and solid-state was studied towards a poorly water-soluble bioflavonoid, quercetin (QURC), chemically 3,3',4',5',7-pentahydroxy flavone. Drug-cyclodextrin solid systems were prepared by freeze-drying. Phase solubility study was used to evaluate the complexation in solution, of two cyclodextrins, i.e., betaCD and HPbetaCD. The stoichiometry and stability constants of QURC-betaCD (1:1 and 402M(-1)) and QURC-HPbetaCD (1:1 and 532M(-1)) complexes were calculated by phase solubility method. The formation of inclusion complexes with betaCD and HPbetaCD in the solid-state were confirmed by infrared spectroscopy, differential scanning calorimetry, X-ray diffractometry, and scanning electron microscopy (SEM). SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/15013147/Study_of_freeze_dried_quercetin_cyclodextrin_binary_systems_by_DSC_FT_IR_X_ray_diffraction_and_SEM_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731708503005296 DB - PRIME DP - Unbound Medicine ER -