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Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract.
J Ethnopharmacol. 2004 Feb; 90(2-3):317-21.JE

Abstract

A methanol extract of the dried leaves of Tithonia diversifolia was investigated for anti-inflammatory and analgesic activities. The extract (50-200 mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. At the same doses, analgesic effect was also observed with hot plate latency assays maintained at (55 degrees C) as well as on the early and late phases of formalin-induced paw licking in rats. The results of the present study further confirm the use of Tithonia diversifolia traditionally for the treatment of painful inflammatory conditions.

Authors+Show Affiliations

Owoyele VB
Department of Physiology and Biochemistry, University of Ilorin, PMB 1515, Ilorin, Nigeria. deleyele@yahoo.com
Wuraola CO
No affiliation info available
Soladoye AO
No affiliation info available
Olaleye SB
No affiliation info available

MeSH

Analgesics, Non-NarcoticAnimalsAnti-Inflammatory Agents, Non-SteroidalAsteraceaeEdemaMalePain MeasurementPlant ExtractsPlant LeavesRatsRats, Wistar

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15013196

Citation

Owoyele, Victor B., et al. "Studies On the Anti-inflammatory and Analgesic Properties of Tithonia Diversifolia Leaf Extract." Journal of Ethnopharmacology, vol. 90, no. 2-3, 2004, pp. 317-21.
Owoyele VB, Wuraola CO, Soladoye AO, et al. Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract. J Ethnopharmacol. 2004;90(2-3):317-21.
Owoyele, V. B., Wuraola, C. O., Soladoye, A. O., & Olaleye, S. B. (2004). Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract. Journal of Ethnopharmacology, 90(2-3), 317-21.
Owoyele VB, et al. Studies On the Anti-inflammatory and Analgesic Properties of Tithonia Diversifolia Leaf Extract. J Ethnopharmacol. 2004;90(2-3):317-21. PubMed PMID: 15013196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract. AU - Owoyele,Victor B, AU - Wuraola,Caleb O, AU - Soladoye,Ayodele O, AU - Olaleye,Samuel B, PY - 2003/05/01/received PY - 2003/08/08/revised PY - 2003/10/09/accepted PY - 2004/3/12/pubmed PY - 2004/4/13/medline PY - 2004/3/12/entrez SP - 317 EP - 21 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 90 IS - 2-3 N2 - A methanol extract of the dried leaves of Tithonia diversifolia was investigated for anti-inflammatory and analgesic activities. The extract (50-200 mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. At the same doses, analgesic effect was also observed with hot plate latency assays maintained at (55 degrees C) as well as on the early and late phases of formalin-induced paw licking in rats. The results of the present study further confirm the use of Tithonia diversifolia traditionally for the treatment of painful inflammatory conditions. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15013196/Studies_on_the_anti_inflammatory_and_analgesic_properties_of_Tithonia_diversifolia_leaf_extract_ DB - PRIME DP - Unbound Medicine ER -