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Causes of anemia in renal transplant recipients.
Transplant Proc 2004 Jan-Feb; 36(1):164-5TP

Abstract

Iron-deficiency anemia is one of the major problems encountered in renal transplant recipients. The aim of this retrospective study was to reevaluate the causes of anemia among 100 anemic kidney recipients. Patients with serum creatinine levels greater than 2 mg/dL were excluded from the study. Female patients were considered to be anemic if the hemoglobin was <12 g/dL for males, <13 g/dL. Complete blood count, serum creatinine, serum iron, iron-binding capacity, ferritin, transferrin saturation, erythrocyte folate, and serum vitamin B(12) levels were measured in all patients. Mean hemoglobin value was 10.2 +/- 1.4 g/dL for female and 9.9 +/- 1.3 for male patients, mean corpuscular volume (MCV) 91.3 +/- 4.9 fL. We observed normocytic anemia in 60, macrocytic anemia in 30, and microcytic anemia in 10 patients. A low level of serum folate was observed in 9 (15%) and of vitamin B(12) in 5 (8.8%) of 60 patients with normocytic anemia. Folate deficiency was found in 18 (60%) and vitamin B(12) deficiency in 12 (40%) of 30 patients with macrocytic anemia. All patients with microcytic anemia had iron deficiency. Splenomegaly was seen significantly more often in patients with macrocytic than normocytic anemia (P =.008). Folate and vitamin B(12) deficiency were the major causes of nutritional anemia; oral or parenteral supplementation with these vitamins is likely to cure the anemia in the majority of cases.

Authors+Show Affiliations

Division of Hematology, Baskent University Hospital, Ankara, Turkey. sema_karakus@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15013334

Citation

Karakuş, S, et al. "Causes of Anemia in Renal Transplant Recipients." Transplantation Proceedings, vol. 36, no. 1, 2004, pp. 164-5.
Karakuş S, Kanbay M, Köseoğlu HK, et al. Causes of anemia in renal transplant recipients. Transplant Proc. 2004;36(1):164-5.
Karakuş, S., Kanbay, M., Köseoğlu, H. K., Colak, T., & Haberal, M. (2004). Causes of anemia in renal transplant recipients. Transplantation Proceedings, 36(1), pp. 164-5.
Karakuş S, et al. Causes of Anemia in Renal Transplant Recipients. Transplant Proc. 2004;36(1):164-5. PubMed PMID: 15013334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Causes of anemia in renal transplant recipients. AU - Karakuş,S, AU - Kanbay,M, AU - Köseoğlu,H Kart, AU - Colak,T, AU - Haberal,M, PY - 2004/3/12/pubmed PY - 2004/10/6/medline PY - 2004/3/12/entrez SP - 164 EP - 5 JF - Transplantation proceedings JO - Transplant. Proc. VL - 36 IS - 1 N2 - Iron-deficiency anemia is one of the major problems encountered in renal transplant recipients. The aim of this retrospective study was to reevaluate the causes of anemia among 100 anemic kidney recipients. Patients with serum creatinine levels greater than 2 mg/dL were excluded from the study. Female patients were considered to be anemic if the hemoglobin was <12 g/dL for males, <13 g/dL. Complete blood count, serum creatinine, serum iron, iron-binding capacity, ferritin, transferrin saturation, erythrocyte folate, and serum vitamin B(12) levels were measured in all patients. Mean hemoglobin value was 10.2 +/- 1.4 g/dL for female and 9.9 +/- 1.3 for male patients, mean corpuscular volume (MCV) 91.3 +/- 4.9 fL. We observed normocytic anemia in 60, macrocytic anemia in 30, and microcytic anemia in 10 patients. A low level of serum folate was observed in 9 (15%) and of vitamin B(12) in 5 (8.8%) of 60 patients with normocytic anemia. Folate deficiency was found in 18 (60%) and vitamin B(12) deficiency in 12 (40%) of 30 patients with macrocytic anemia. All patients with microcytic anemia had iron deficiency. Splenomegaly was seen significantly more often in patients with macrocytic than normocytic anemia (P =.008). Folate and vitamin B(12) deficiency were the major causes of nutritional anemia; oral or parenteral supplementation with these vitamins is likely to cure the anemia in the majority of cases. SN - 0041-1345 UR - https://www.unboundmedicine.com/medline/citation/15013334/Causes_of_anemia_in_renal_transplant_recipients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041134503012168 DB - PRIME DP - Unbound Medicine ER -