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Aging and prefrontal functions: dissociating orbitofrontal and dorsolateral abilities.
Neurobiol Aging 2004; 25(4):553-8NA

Abstract

This study aimed to determine whether age differentially affects performance on tasks tapping orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC). We administered prefrontal measures to healthy younger (n=23; age= 28.4+/-5.9, education = 15.7+/-2.6, MMSE=29.5+/-0.6) and older participants (n=20; age=69.1+/-5.0, education =15.5+/-3.4, MMSE =28.9+/-1.5). Groups did not differ on education or mental status, P>0.05. Tasks thought to involve greater OFC processing included the Iowa Gambling Task and Delayed Match and Non-Match to Sample Tasks. Tasks requiring greater DLPFC processing included Petrides' Self-Ordered Pointing, WAIS-R Digit Span Backward, Letter Fluency, and Months Backward from the Boston Revision of WMS-Mental Control. Composite z-scores were calculated for OFC and DLPFC tasks. A 2 x 2 ANOVA revealed a Group x Task interaction: F(1,41) =5.55, P=0.02, and a Group main effect: F(1,41)= 12.16, P=0.001. Follow-up analyses revealed younger adults outperformed older adults on OFC tasks only (younger = 0.37+/-0.46, older= -0.43+/-0.70; t(41) =4.5, P<0.001). Post-hoc analyses of individual tasks confirmed that despite age differences on Petrides' Self-Ordered Pointing, measures requiring relatively greater OFC involvement showed larger effect sizes for age differences. Thus, tasks emphasizing OFC functions appear more sensitive to age effects when directly compared to measures of DLPFC functioning. Reasons for this difference in magnitude may stem from differential aging of prefrontal cortex or differential recruitment of alternative brain regions for successful task completion.

Authors+Show Affiliations

Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224 USA. me2325@columbia.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15013577

Citation

Lamar, Melissa, and Susan M. Resnick. "Aging and Prefrontal Functions: Dissociating Orbitofrontal and Dorsolateral Abilities." Neurobiology of Aging, vol. 25, no. 4, 2004, pp. 553-8.
Lamar M, Resnick SM. Aging and prefrontal functions: dissociating orbitofrontal and dorsolateral abilities. Neurobiol Aging. 2004;25(4):553-8.
Lamar, M., & Resnick, S. M. (2004). Aging and prefrontal functions: dissociating orbitofrontal and dorsolateral abilities. Neurobiology of Aging, 25(4), pp. 553-8.
Lamar M, Resnick SM. Aging and Prefrontal Functions: Dissociating Orbitofrontal and Dorsolateral Abilities. Neurobiol Aging. 2004;25(4):553-8. PubMed PMID: 15013577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aging and prefrontal functions: dissociating orbitofrontal and dorsolateral abilities. AU - Lamar,Melissa, AU - Resnick,Susan M, PY - 2003/03/04/received PY - 2003/06/03/revised PY - 2003/06/25/accepted PY - 2004/3/12/pubmed PY - 2004/5/12/medline PY - 2004/3/12/entrez SP - 553 EP - 8 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 25 IS - 4 N2 - This study aimed to determine whether age differentially affects performance on tasks tapping orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC). We administered prefrontal measures to healthy younger (n=23; age= 28.4+/-5.9, education = 15.7+/-2.6, MMSE=29.5+/-0.6) and older participants (n=20; age=69.1+/-5.0, education =15.5+/-3.4, MMSE =28.9+/-1.5). Groups did not differ on education or mental status, P>0.05. Tasks thought to involve greater OFC processing included the Iowa Gambling Task and Delayed Match and Non-Match to Sample Tasks. Tasks requiring greater DLPFC processing included Petrides' Self-Ordered Pointing, WAIS-R Digit Span Backward, Letter Fluency, and Months Backward from the Boston Revision of WMS-Mental Control. Composite z-scores were calculated for OFC and DLPFC tasks. A 2 x 2 ANOVA revealed a Group x Task interaction: F(1,41) =5.55, P=0.02, and a Group main effect: F(1,41)= 12.16, P=0.001. Follow-up analyses revealed younger adults outperformed older adults on OFC tasks only (younger = 0.37+/-0.46, older= -0.43+/-0.70; t(41) =4.5, P<0.001). Post-hoc analyses of individual tasks confirmed that despite age differences on Petrides' Self-Ordered Pointing, measures requiring relatively greater OFC involvement showed larger effect sizes for age differences. Thus, tasks emphasizing OFC functions appear more sensitive to age effects when directly compared to measures of DLPFC functioning. Reasons for this difference in magnitude may stem from differential aging of prefrontal cortex or differential recruitment of alternative brain regions for successful task completion. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/15013577/Aging_and_prefrontal_functions:_dissociating_orbitofrontal_and_dorsolateral_abilities_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197458003001830 DB - PRIME DP - Unbound Medicine ER -