Tags

Type your tag names separated by a space and hit enter

Protein intake and blood glucose as modulators of GFR in hyperfiltering diabetic patients.
Kidney Int. 1992 Jun; 41(6):1620-8.KI

Abstract

Glomerular hyperfiltration has been claimed to be a risk factor for the development of diabetic nephropathy. Protein intake and hyperglycemia can both increase GFR in diabetic and normal subjects. Our study was designed to explore the relative importance of short-term changes in protein intake and glycemia on the modulation of renal hemodynamics in insulin-dependent diabetic (IDDM) patients with and without glomerular hyperfiltration. The renal hemodynamic response to a protein challenge was studied in eight hyperfiltering (HF) and eight normofiltering (NF) patients after a three week period of low or normal protein diet (LPD, NPD), each study being conducted twice, in random order, under conditions of prevailing hyperglycemia (H) and euglycemia (E). In HF patients GFR failed to increase significantly in response to protein challenge during NPD under conditions of either H or E (Baseline vs. 2 hr H: 151 +/- 4 vs. 155 +/- 6, NS; E 147 +/- 4 vs. 157 +/- 7 ml/min/1.73 m2, NS). A more normal response was restored following LPD with GFR increasing in all but one patient after challenge during H and in all patients during E (Baseline vs. 2 hr H: 130 +/- 7 vs. 145 +/- 8, P less than 0.07; E: 127 +/- 7 vs. 143 +/- 7 ml/min/1.73 m2, P less than 0.01). Changes in RPF paralleled the changes in GFR and filtration fraction remained stable under all study conditions.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Jones SL
Unit for Metabolic Medicine, UMDS Guy's Hospital, London, England, United Kingdom.
Kontessis P
No affiliation info available
Wiseman M
No affiliation info available
Dodds R
No affiliation info available
Bognetti E
No affiliation info available
Pinto J
No affiliation info available
Viberti G
No affiliation info available

MeSH

AdultBlood GlucoseCreatinineDiabetes Mellitus, Type 1Dietary ProteinsGlomerular Filtration RateGlucagonHumansMaleMiddle AgedRenal CirculationUrea

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1501418

Citation

Jones, S L., et al. "Protein Intake and Blood Glucose as Modulators of GFR in Hyperfiltering Diabetic Patients." Kidney International, vol. 41, no. 6, 1992, pp. 1620-8.
Jones SL, Kontessis P, Wiseman M, et al. Protein intake and blood glucose as modulators of GFR in hyperfiltering diabetic patients. Kidney Int. 1992;41(6):1620-8.
Jones, S. L., Kontessis, P., Wiseman, M., Dodds, R., Bognetti, E., Pinto, J., & Viberti, G. (1992). Protein intake and blood glucose as modulators of GFR in hyperfiltering diabetic patients. Kidney International, 41(6), 1620-8.
Jones SL, et al. Protein Intake and Blood Glucose as Modulators of GFR in Hyperfiltering Diabetic Patients. Kidney Int. 1992;41(6):1620-8. PubMed PMID: 1501418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protein intake and blood glucose as modulators of GFR in hyperfiltering diabetic patients. AU - Jones,S L, AU - Kontessis,P, AU - Wiseman,M, AU - Dodds,R, AU - Bognetti,E, AU - Pinto,J, AU - Viberti,G, PY - 1992/6/1/pubmed PY - 1992/6/1/medline PY - 1992/6/1/entrez SP - 1620 EP - 8 JF - Kidney international JO - Kidney Int VL - 41 IS - 6 N2 - Glomerular hyperfiltration has been claimed to be a risk factor for the development of diabetic nephropathy. Protein intake and hyperglycemia can both increase GFR in diabetic and normal subjects. Our study was designed to explore the relative importance of short-term changes in protein intake and glycemia on the modulation of renal hemodynamics in insulin-dependent diabetic (IDDM) patients with and without glomerular hyperfiltration. The renal hemodynamic response to a protein challenge was studied in eight hyperfiltering (HF) and eight normofiltering (NF) patients after a three week period of low or normal protein diet (LPD, NPD), each study being conducted twice, in random order, under conditions of prevailing hyperglycemia (H) and euglycemia (E). In HF patients GFR failed to increase significantly in response to protein challenge during NPD under conditions of either H or E (Baseline vs. 2 hr H: 151 +/- 4 vs. 155 +/- 6, NS; E 147 +/- 4 vs. 157 +/- 7 ml/min/1.73 m2, NS). A more normal response was restored following LPD with GFR increasing in all but one patient after challenge during H and in all patients during E (Baseline vs. 2 hr H: 130 +/- 7 vs. 145 +/- 8, P less than 0.07; E: 127 +/- 7 vs. 143 +/- 7 ml/min/1.73 m2, P less than 0.01). Changes in RPF paralleled the changes in GFR and filtration fraction remained stable under all study conditions.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0085-2538 UR - https://www.unboundmedicine.com/medline/citation/1501418/Protein_intake_and_blood_glucose_as_modulators_of_GFR_in_hyperfiltering_diabetic_patients_ DB - PRIME DP - Unbound Medicine ER -