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HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of Leptospirosis.
Genes Immun. 2004 May; 5(3):197-202.GI

Abstract

Leptospirosis is a zoonosis that can cause severe multisystem disease. While host gene-environment interactions likely modify infectious disease susceptibility, including for leptopsirosis, this has not been documented. In a 1998 leptospirosis outbreak investigation among triathletes in a lake swim, swallowing lake-water was a disease risk-factor. We used genomic DNA from 85 anonymized blood-sample remainders from that investigation to examine the association of laboratory-confirmed leptospirosis with gene polymorphisms (TNF-alpha alleles and serologically defined genotypes for HLA-DRB1 and HLA-DQB1). HLA-DQ6-positive triathletes had increased risk of laboratory-confirmed leptospirosis (OR=2.8, P=0.04) compared to DQ6-negatives. DQ6-positive triathletes swallowing lake-water had greatest risk (OR 8.46, P< or =0.001). This first report of a genetic risk-factor affecting susceptibility to leptospirosis is also the first documented gene-environment interaction (DQ6 and swallowed water) affecting infectious disease susceptibility. Based on these preliminary findings, we hypothesize a role for superantigens in leptospirosis and underscore the importance of outbreak investigations for understanding infectious disease gene-environment interactions.

Authors+Show Affiliations

Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. JWL8@CDC.GOVNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

15014429

Citation

Lingappa, J, et al. "HLA-DQ6 and Ingestion of Contaminated Water: Possible Gene-environment Interaction in an Outbreak of Leptospirosis." Genes and Immunity, vol. 5, no. 3, 2004, pp. 197-202.
Lingappa J, Kuffner T, Tappero J, et al. HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of Leptospirosis. Genes Immun. 2004;5(3):197-202.
Lingappa, J., Kuffner, T., Tappero, J., Whitworth, W., Mize, A., Kaiser, R., & McNicholl, J. (2004). HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of Leptospirosis. Genes and Immunity, 5(3), 197-202.
Lingappa J, et al. HLA-DQ6 and Ingestion of Contaminated Water: Possible Gene-environment Interaction in an Outbreak of Leptospirosis. Genes Immun. 2004;5(3):197-202. PubMed PMID: 15014429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of Leptospirosis. AU - Lingappa,J, AU - Kuffner,T, AU - Tappero,J, AU - Whitworth,W, AU - Mize,A, AU - Kaiser,R, AU - McNicholl,J, PY - 2004/3/12/pubmed PY - 2004/11/9/medline PY - 2004/3/12/entrez SP - 197 EP - 202 JF - Genes and immunity JO - Genes Immun VL - 5 IS - 3 N2 - Leptospirosis is a zoonosis that can cause severe multisystem disease. While host gene-environment interactions likely modify infectious disease susceptibility, including for leptopsirosis, this has not been documented. In a 1998 leptospirosis outbreak investigation among triathletes in a lake swim, swallowing lake-water was a disease risk-factor. We used genomic DNA from 85 anonymized blood-sample remainders from that investigation to examine the association of laboratory-confirmed leptospirosis with gene polymorphisms (TNF-alpha alleles and serologically defined genotypes for HLA-DRB1 and HLA-DQB1). HLA-DQ6-positive triathletes had increased risk of laboratory-confirmed leptospirosis (OR=2.8, P=0.04) compared to DQ6-negatives. DQ6-positive triathletes swallowing lake-water had greatest risk (OR 8.46, P< or =0.001). This first report of a genetic risk-factor affecting susceptibility to leptospirosis is also the first documented gene-environment interaction (DQ6 and swallowed water) affecting infectious disease susceptibility. Based on these preliminary findings, we hypothesize a role for superantigens in leptospirosis and underscore the importance of outbreak investigations for understanding infectious disease gene-environment interactions. SN - 1466-4879 UR - https://www.unboundmedicine.com/medline/citation/15014429/HLA_DQ6_and_ingestion_of_contaminated_water:_possible_gene_environment_interaction_in_an_outbreak_of_Leptospirosis_ L2 - https://doi.org/10.1038/sj.gene.6364058 DB - PRIME DP - Unbound Medicine ER -