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Effect of interferon beta-1a on serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in relapsing remitting multiple sclerosis patients. One year follow-up results.
J Neurol. 2004 Mar; 251(3):279-83.JN

Abstract

There is emerging evidence that matrix metalloproteinases (MMPs) might be involved in blood brain barrier (BBB) breakdown in multiple sclerosis. A group of natural tissue inhibitors of metalloproteinases (TIMPS) regulates proteolytic activity to prevent tissue damage. TIMP-1 and MMP-9 are known to be secreted as heterodimers and TIMP-1 preferentially functions to inhibit MMP-9 activity. In this present study, the effects of IFNbeta-1a on serum MMP-9 and TIMP-1 were evaluated longitudinally during a one-year period. The MMP-9 levels showed no significant changes while TIMP-1 levels gradually and significantly increased during 3rd and 6th months of therapy compared with pretreatment levels.

Authors+Show Affiliations

Hacettepe University, Faculty of Medicine, Department of Neurology, Neuroimmunology Unit, 06100 Ankara, Turkey. rkbudak@hacettepe.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15015006

Citation

Karabudak, Rana, et al. "Effect of Interferon Beta-1a On Serum Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Matrix Metalloproteinase (TIMP-1) in Relapsing Remitting Multiple Sclerosis Patients. One Year Follow-up Results." Journal of Neurology, vol. 251, no. 3, 2004, pp. 279-83.
Karabudak R, Kurne A, Guc D, et al. Effect of interferon beta-1a on serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in relapsing remitting multiple sclerosis patients. One year follow-up results. J Neurol. 2004;251(3):279-83.
Karabudak, R., Kurne, A., Guc, D., Sengelen, M., Canpinar, H., & Kansu, E. (2004). Effect of interferon beta-1a on serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in relapsing remitting multiple sclerosis patients. One year follow-up results. Journal of Neurology, 251(3), 279-83.
Karabudak R, et al. Effect of Interferon Beta-1a On Serum Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Matrix Metalloproteinase (TIMP-1) in Relapsing Remitting Multiple Sclerosis Patients. One Year Follow-up Results. J Neurol. 2004;251(3):279-83. PubMed PMID: 15015006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of interferon beta-1a on serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in relapsing remitting multiple sclerosis patients. One year follow-up results. AU - Karabudak,Rana, AU - Kurne,Asli, AU - Guc,Dicle, AU - Sengelen,Meltem, AU - Canpinar,Hande, AU - Kansu,Emin, PY - 2002/11/05/received PY - 2003/06/18/revised PY - 2003/09/24/accepted PY - 2004/3/12/pubmed PY - 2004/5/20/medline PY - 2004/3/12/entrez SP - 279 EP - 83 JF - Journal of neurology JO - J Neurol VL - 251 IS - 3 N2 - There is emerging evidence that matrix metalloproteinases (MMPs) might be involved in blood brain barrier (BBB) breakdown in multiple sclerosis. A group of natural tissue inhibitors of metalloproteinases (TIMPS) regulates proteolytic activity to prevent tissue damage. TIMP-1 and MMP-9 are known to be secreted as heterodimers and TIMP-1 preferentially functions to inhibit MMP-9 activity. In this present study, the effects of IFNbeta-1a on serum MMP-9 and TIMP-1 were evaluated longitudinally during a one-year period. The MMP-9 levels showed no significant changes while TIMP-1 levels gradually and significantly increased during 3rd and 6th months of therapy compared with pretreatment levels. SN - 0340-5354 UR - https://www.unboundmedicine.com/medline/citation/15015006/Effect_of_interferon_beta_1a_on_serum_matrix_metalloproteinase_9__MMP_9__and_tissue_inhibitor_of_matrix_metalloproteinase__TIMP_1__in_relapsing_remitting_multiple_sclerosis_patients__One_year_follow_up_results_ L2 - https://dx.doi.org/10.1007/s00415-004-0285-7 DB - PRIME DP - Unbound Medicine ER -