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[The effect of niaoduqing tablet on the diuresis in normal rats and the hemorheology in blood-stasis rats].
Zhongguo Zhong Yao Za Zhi. 2003 Mar; 28(3):250-3.ZZ

Abstract

OBJECTIVE

To observe the effect of the Niaoduqing Tablet(NDT) on the diuresis in normal rats and the hemorheology in rats of blood stasis and compare it with the Niaoduqing Granule(NDG), so as to provide some laboratory data for the clinic application and innovation of the dosage forms.

METHOD

Diuretic effect of the NDT on experimental rats burthened with 1% Sodium deoxycholate was observed by using the metabolize cage examination. The changes of whole blood and plasma viscosity in the blood-stasis rat-model were measured with Viscometer-R80. Plasma was separated and fibrinogen measured by using the turbidimetric method.

RESULT

Every dose of NDT had the diuretic effect on experiment rats, but only the big and middle dose increasing the urine quantity in 6 hours had the significance. Each dose could reduce the viscosity of whole blood and the fibrinogen in the blood-stasis rat model, and had the superiority to NDG.

CONCLUSIONS

NDT has the diuretic effect and can ameliorate the hemorheology in the blood-stasis rat model, which may delay the course of the chronic renal failure (CRF).

Authors+Show Affiliations

Laboratory of Traditional Medicine Department, First Military Medical University, Guangzhou 510515, Guangdong, China. denghz@fimmu.comNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15015313

Citation

Deng, Hong-zhu, et al. "[The Effect of Niaoduqing Tablet On the Diuresis in Normal Rats and the Hemorheology in Blood-stasis Rats]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 28, no. 3, 2003, pp. 250-3.
Deng HZ, Xiao W, Chen YY. [The effect of niaoduqing tablet on the diuresis in normal rats and the hemorheology in blood-stasis rats]. Zhongguo Zhong Yao Za Zhi. 2003;28(3):250-3.
Deng, H. Z., Xiao, W., & Chen, Y. Y. (2003). [The effect of niaoduqing tablet on the diuresis in normal rats and the hemorheology in blood-stasis rats]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 28(3), 250-3.
Deng HZ, Xiao W, Chen YY. [The Effect of Niaoduqing Tablet On the Diuresis in Normal Rats and the Hemorheology in Blood-stasis Rats]. Zhongguo Zhong Yao Za Zhi. 2003;28(3):250-3. PubMed PMID: 15015313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect of niaoduqing tablet on the diuresis in normal rats and the hemorheology in blood-stasis rats]. AU - Deng,Hong-zhu, AU - Xiao,Wei, AU - Chen,Yu-yao, PY - 2004/3/16/pubmed PY - 2004/7/16/medline PY - 2004/3/16/entrez SP - 250 EP - 3 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 28 IS - 3 N2 - OBJECTIVE: To observe the effect of the Niaoduqing Tablet(NDT) on the diuresis in normal rats and the hemorheology in rats of blood stasis and compare it with the Niaoduqing Granule(NDG), so as to provide some laboratory data for the clinic application and innovation of the dosage forms. METHOD: Diuretic effect of the NDT on experimental rats burthened with 1% Sodium deoxycholate was observed by using the metabolize cage examination. The changes of whole blood and plasma viscosity in the blood-stasis rat-model were measured with Viscometer-R80. Plasma was separated and fibrinogen measured by using the turbidimetric method. RESULT: Every dose of NDT had the diuretic effect on experiment rats, but only the big and middle dose increasing the urine quantity in 6 hours had the significance. Each dose could reduce the viscosity of whole blood and the fibrinogen in the blood-stasis rat model, and had the superiority to NDG. CONCLUSIONS: NDT has the diuretic effect and can ameliorate the hemorheology in the blood-stasis rat model, which may delay the course of the chronic renal failure (CRF). SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/15015313/[The_effect_of_niaoduqing_tablet_on_the_diuresis_in_normal_rats_and_the_hemorheology_in_blood_stasis_rats]_ DB - PRIME DP - Unbound Medicine ER -