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Alcohol consumption and risk of stroke among middle-aged men: the JPHC Study Cohort I.
Stroke 2004; 35(5):1124-9S

Abstract

BACKGROUND AND PURPOSE

The impact of light-to-moderate alcohol consumption on risk of stroke has not been well examined in a single study, although the effect is hypothesized to differ among stroke subtypes from meta-analyses.

METHODS

A total of 19 544 men aged 40 to 59 years living in communities were followed-up from 1990 to 1992 to the end of 2001 in the Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Disease (JPHC Study).

RESULTS

After 214 504 person-years of follow-up, 694 incident strokes were documented, of which 611 were confirmed by imaging studies or autopsy, including 219 intraparenchymal hemorrhages, 73 subarachnoid hemorrhages, and 319 ischemic strokes. Alcohol consumption was positively associated with age-adjusted risk of total stroke with a 68% excess risk among drinkers of > or =450 g ethanol per week compared with occasional drinkers. This excess risk was confined primarily to hemorrhagic stroke, which remained statistically significant even after controlling for hypertension and other cardiovascular risk factors (RR: 2.15; 95% CI: 1.22 to 3.79). There was a lower risk of ischemic stroke, more specifically lacunar infarction, a higher risk of hemorrhagic stroke, and no excess risk of total stroke among drinkers of 1 to 149 g ethanol per week compared with occasional drinkers; the respective multivariate RR (95% CI) was 0.59 (0.37 to 0.93), 0.43 (0.22 to 0.87), 1.73 (0.98 to 3.07), and 0.98 (0.71 to 1.36).

CONCLUSIONS

We found differential effects of light-to-moderate alcohol consumption on risks of hemorrhagic and ischemic strokes among middle-aged men. Light-to-moderate alcohol consumption, ie, < or =2 drinks per day, does not raise the risk of total stroke.

Authors+Show Affiliations

Department of Public Health Medicine, Institute of Community Medicine, University of Tsukuba, 1-1-1 Tennodai, Tuskuba-shi, Ibaraki-ken 305-3985 Japan. fvgh5640@mb.infoweb.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15017008

Citation

Iso, Hiroyasu, et al. "Alcohol Consumption and Risk of Stroke Among Middle-aged Men: the JPHC Study Cohort I." Stroke, vol. 35, no. 5, 2004, pp. 1124-9.
Iso H, Baba S, Mannami T, et al. Alcohol consumption and risk of stroke among middle-aged men: the JPHC Study Cohort I. Stroke. 2004;35(5):1124-9.
Iso, H., Baba, S., Mannami, T., Sasaki, S., Okada, K., Konishi, M., & Tsugane, S. (2004). Alcohol consumption and risk of stroke among middle-aged men: the JPHC Study Cohort I. Stroke, 35(5), pp. 1124-9.
Iso H, et al. Alcohol Consumption and Risk of Stroke Among Middle-aged Men: the JPHC Study Cohort I. Stroke. 2004;35(5):1124-9. PubMed PMID: 15017008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and risk of stroke among middle-aged men: the JPHC Study Cohort I. AU - Iso,Hiroyasu, AU - Baba,Shunroku, AU - Mannami,Toshifumi, AU - Sasaki,Satoshi, AU - Okada,Katsutoshi, AU - Konishi,Masamitsu, AU - Tsugane,Shoichiro, AU - ,, Y1 - 2004/03/11/ PY - 2004/3/16/pubmed PY - 2004/5/20/medline PY - 2004/3/16/entrez SP - 1124 EP - 9 JF - Stroke JO - Stroke VL - 35 IS - 5 N2 - BACKGROUND AND PURPOSE: The impact of light-to-moderate alcohol consumption on risk of stroke has not been well examined in a single study, although the effect is hypothesized to differ among stroke subtypes from meta-analyses. METHODS: A total of 19 544 men aged 40 to 59 years living in communities were followed-up from 1990 to 1992 to the end of 2001 in the Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Disease (JPHC Study). RESULTS: After 214 504 person-years of follow-up, 694 incident strokes were documented, of which 611 were confirmed by imaging studies or autopsy, including 219 intraparenchymal hemorrhages, 73 subarachnoid hemorrhages, and 319 ischemic strokes. Alcohol consumption was positively associated with age-adjusted risk of total stroke with a 68% excess risk among drinkers of > or =450 g ethanol per week compared with occasional drinkers. This excess risk was confined primarily to hemorrhagic stroke, which remained statistically significant even after controlling for hypertension and other cardiovascular risk factors (RR: 2.15; 95% CI: 1.22 to 3.79). There was a lower risk of ischemic stroke, more specifically lacunar infarction, a higher risk of hemorrhagic stroke, and no excess risk of total stroke among drinkers of 1 to 149 g ethanol per week compared with occasional drinkers; the respective multivariate RR (95% CI) was 0.59 (0.37 to 0.93), 0.43 (0.22 to 0.87), 1.73 (0.98 to 3.07), and 0.98 (0.71 to 1.36). CONCLUSIONS: We found differential effects of light-to-moderate alcohol consumption on risks of hemorrhagic and ischemic strokes among middle-aged men. Light-to-moderate alcohol consumption, ie, < or =2 drinks per day, does not raise the risk of total stroke. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/15017008/Alcohol_consumption_and_risk_of_stroke_among_middle_aged_men:_the_JPHC_Study_Cohort_I_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.STR.0000124459.33597.00?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -